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Cellosaurus HL-60 (CVCL_0002)

[Text version]
Cell line name HL-60
Synonyms HL 60; HL.60; HL60; Human Leukemia-60
Accession CVCL_0002
Resource Identification Initiative To cite this cell line use: HL-60 (RRID:CVCL_0002)
Comments Group: Space-flown cell line (cellonaut).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: ENCODE project common cell types; tier 3.
Part of: Human Protein Atlas, Cell Atlas panel.
Part of: LL-100 blood cancer cell line panel.
Part of: MD Anderson Cell Lines Project.
Part of: MYC genetic alteration cell panel (ATCC TCP-1035).
Registration: National Institute of Standards and Technology, Standard Reference Materials; SRM 2392-I.
Population: Caucasian.
Biotechnology: Used a source of mitochondrial DNA for USA forensic testing.
Virology: Not susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=33389257).
Doubling time: 16 hours (PubMed=8343448); 28 hours (PubMed=25984343); ~40 hours (DSMZ=ACC-3).
Microsatellite instability: Stable (MSS) (PubMed=10739008; PubMed=11226526; PubMed=12661003; Sanger).
Omics: Genomics; ChIP-seq; CTCF.
Omics: Genomics; ChIP-seq; H3K4me3.
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Mitochondrial genome sequencing.
Omics: Genomics; Whole exome sequencing.
Omics: Glycomics; N-glycan profiling.
Omics: Phenotyping; Drug screening.
Omics: Phenotyping; shRNA library screening.
Omics: Proteomics; Expression; Large antibody panel staining analysis.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Proteomics; Subcellular; Cell surface.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; CNV analysis.
Omics: Variations; SNP array analysis.
Anecdotal: Established at the 60th attempt to culture human leukemia biopsies in Gallo's lab. All the preceding attempts having failed.
Misspelling: IIL-60; Note=Occasionally.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (PubMed=2858093).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (PubMed=17088437; Cosmic-CLP=905938; DepMap=ACH-000002).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (PubMed=12068308; PubMed=17088437; Cosmic-CLP=905938; DepMap=ACH-000002).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*01:01,24:15
HLA-BB*57:01,57:01
HLA-CC*06:02,06:02

Source: DSMZCellDive=ACC-3
Class I
HLA-BB*57:01:01,57:01:01
HLA-CC*06:02:01,06:02:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.15
Native American0.42
East Asian, North0.4
East Asian, South0
South Asian0
European, North71.71
European, South26.32
Disease Adult acute myeloid leukemia with maturation (NCIt: C7961)
Acute myeloblastic leukemia with maturation (ORDO: Orphanet_98834)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_2892 (Eos-HL-60)CVCL_8439 (HIMeg-1)CVCL_UM46 (HL-60 248)
CVCL_VK43 (HL-60 blast)CVCL_2493 (HL-60 clone 15)CVCL_B6DR (HL-60 clone F8)
CVCL_B6DS (HL-60 clone H6)CVCL_WZ17 (HL-60 DeltaF508-CF)CVCL_F0CQ (HL-60 eosinophilic subline No. 3)
CVCL_F0CU (HL-60 neutrophilic subline No. 14)CVCL_F0CT (HL-60 neutrophilic subline No. 8)CVCL_UM47 (HL-60 SCX3)
CVCL_UM48 (HL-60 SN3)CVCL_E7J6 (HL-60(Cas9))CVCL_C8HP (HL-60(DM))
CVCL_A794 (HL-60(TB))CVCL_C8HN (HL-60-79B)CVCL_A4BY (HL-60-Luc2)
CVCL_4635 (HL-60-R2)CVCL_WW75 (HL-60-Y3)CVCL_YP33 (HL-60/5FU)
CVCL_0304 (HL-60/ADR)CVCL_IP18 (HL-60/AMSA)CVCL_WR44 (HL-60/AR)
CVCL_4V19 (HL-60/ara-C [Japan 2011])CVCL_Z938 (HL-60/ara-C [USA 1984])CVCL_C3M3 (HL-60/CDDP)
CVCL_4458 (HL-60/DNR)CVCL_D1L6 (HL-60/LRARa403SN D.2)CVCL_D1L7 (HL-60/LRARa403SN D.5)
CVCL_3332 (HL-60/MX1)CVCL_II78 (HL-60/R3)CVCL_XE38 (HL-60/RS)
CVCL_II77 (HL-60/S4)CVCL_0305 (HL-60/VCR)CVCL_4967 (HL-60/Vinc)
CVCL_YT56 (HL-60R)CVCL_RS49 (HL-60rARA-C2mug/ML)CVCL_4V55 (HL/CAFdA20)
CVCL_AR88 (HL60 Ast.1)CVCL_AR85 (HL60 Ast.25)CVCL_2495 (HL60 Ast.3)
CVCL_2496 (HL60 Ast.4)CVCL_2497 (HL60 M2)CVCL_2498 (HL60 M4)
CVCL_AR89 (HL60 Sp1)CVCL_2944 (HL60(S))CVCL_C1LK (HL60-CDR)
CVCL_WI27 (HL60/AR)CVCL_A0ST (HL60/MRI)CVCL_2945 (HL60RG)
CVCL_8710 (HP100-1)CVCL_8711 (HP50-2)CVCL_E1LB (HyCyte HL-60 KO-hIRAK4)
CVCL_E3HJ (HyCyte HL-60-Luc-GFP)CVCL_YN03 (NDi001-A)CVCL_D567 (OM10.1)
CVCL_0478 (P39)CVCL_2162 (PLB-985)CVCL_8907 (RED-3)
CVCL_J128 (VXG3)CVCL_J129 (XQH)CVCL_8931 (YJ)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
STR profile Source(s): AddexBio=C0003023/4977; ATCC=CCL-240; CCRID; CLS=300209; COG; Cosmic-CLP=905938; DSMZ=ACC-3; ECACC=98070106; JCRB=IFO50022; JCRB=JCRB0085; KCLB=10240; PubMed=11416159; PubMed=25877200; RCB=RCB0041; TKG=TKG 0345

Markers:
AmelogeninX
CSF1PO13,14
D2S133817
D3S135816
D5S81812
D7S82011,12
D8S117912 (DSMZ=ACC-3)
12,13 (ATCC=CCL-240; CCRID; PubMed=11416159; PubMed=25877200)
13 (CLS=300209)
D13S3178,11
D16S53911
D18S5114 (CLS=300209)
14,15 (ATCC=CCL-240; CCRID; DSMZ=ACC-3; PubMed=11416159; PubMed=25877200)
D19S43314
D21S1129,30 (ATCC=CCL-240; CCRID; COG; DSMZ=ACC-3; PubMed=25877200)
30 (CLS=300209; PubMed=11416159)
FGA22,24
Penta D10,11 (DSMZ=ACC-3)
10,12 (ATCC=CCL-240; CLS=300209; PubMed=25877200)
Penta E13 (CLS=300209)
13,14 (ATCC=CCL-240; DSMZ=ACC-3; PubMed=25877200)
TH017,8 (AddexBio=C0003023/4977; ATCC=CCL-240; CCRID; CLS=300209; COG; Cosmic-CLP=905938; DSMZ=ACC-3; JCRB=JCRB0085; KCLB=10240; PubMed=11416159; PubMed=25877200; RCB=RCB0041; TKG=TKG 0345)
8 (ECACC=98070106; JCRB=IFO50022)
TPOX8,11
vWA16

Run an STR similarity search on this cell line
Web pages Info; -; -; https://web.archive.org/web/20201109215324/www.infarktforschung.de/macrophages_cell_lines.html
Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=HL-60
Info; ECACC; -; https://www.culturecollections.org.uk/products/cell-cultures/ecacc-cell-line-profiles/hl60/
Info; ENCODE; -; http://genome.ucsc.edu/ENCODE/protocols/cell/human/HL-60_Stam_protocol.pdf
Info; HPA; -; https://www.proteinatlas.org/learn/cellines
Info; MCLP; -; https://tcpaportal.org/mclp/
Info; StRAP; -; https://strap.nci.nih.gov/celline_detail.php?sample_id=32
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-132.html
Info; Wikipedia; -; https://en.wikipedia.org/wiki/HL60
Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/leukemia-xenograft-model/hl60-xenograft-model/
Publications

PubMed=271272; DOI=10.1038/270347a0
Steven J. Collins, Robert Charles Gallo, Robert E. Gallagher;
Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture.
Nature 270:347-349(1977)

PubMed=288488; DOI=10.1182/blood.V54.3.713.713
Robert E. Gallagher, Steven J. Collins, Jose M. Trujillo, Kenneth B. McCredie, Michael John Ahearn, Schickwann Tsai, Richard S. Metzgar, Gurmit Aulakh, Robert Ting, Francis W. Ruscetti, Robert Charles Gallo;
Characterization of the continuous, differentiating myeloid cell line (HL-60) from a patient with acute promyelocytic leukemia.
Blood 54:713-733(1979)

PubMed=6996765; DOI=10.1182/blood.V56.3.344.344
Harold Phillip Koeffler, David W. Golde;
Human myeloid leukemia cell lines: a review.
Blood 56:344-350(1980)

PubMed=6255959; DOI=10.1016/0014-4827(81)90422-5
Inge Olsson, Tor Olofsson;
Induction of differentiation in a human promyelocytic leukemic cell line (HL-60). Production of granule proteins.
Exp. Cell Res. 131:225-230(1981)

PubMed=6945469; DOI=10.1016/0145-2126(81)90018-7
Pierre P. Major, James Douglas Griffin, Mark David Minden, Donald William Kufe;
A blast subclone of the HL-60 human promyelocytic cell line.
Leuk. Res. 5:429-430(1981)

PubMed=6954533; DOI=10.1073/pnas.79.7.2194; PMCID=PMC346157
Eric H. Westin, Robert Charles Gallo, Suresh K. Arya, Alessandra Eva, Lawrence M. Souza, Marcel Albert Baluda, Stuart A. Aaronson, Flossie Wong-Staal;
Differential expression of the amv gene in human hematopoietic cells.
Proc. Natl. Acad. Sci. U.S.A. 79:2194-2198(1982)

PubMed=6091813; DOI=10.1182/blood.V64.5.1059.1059
Antonio Palumbo, Jun Minowada, Jan Erikson, Carlo Maria Croce, Giovanni Rovera;
Lineage infidelity of a human myelogenous leukemia cell line.
Blood 64:1059-1063(1984)

PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720
Michael Jules Mattes, Carlos Cordon-Cardo, John L. Lewis Jr., Lloyd John Old, Kenneth Oliver Lloyd;
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=2858093; DOI=10.1073/pnas.82.3.790; PMCID=PMC397132
David Wolf, Varda Rotter;
Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells.
Proc. Natl. Acad. Sci. U.S.A. 82:790-794(1985)

PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cell lines -- 1 Carboxylic esterase.
Leuk. Res. 9:209-229(1985)

PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cell lines -- III Beta-hexosaminidase (E.C. 3.2.1.30).
Leuk. Res. 9:549-559(1985)

PubMed=3860286
Kapil N. Bhalla, Alexander A. Hindenburg, Robert N. Taub, Steven Grant;
Isolation and characterization of an anthracycline-resistant human leukemic cell line.
Cancer Res. 45:3657-3662(1985)

PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.
Leuk. Res. 9:537-548(1985)

PubMed=3311197; DOI=10.1182/blood.V70.5.1233.1233
Steven J. Collins;
The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression.
Blood 70:1233-1244(1987)

DOI=10.1159/000415060
Shigeru Morikawa, Takayuki Harada, Taizo Katoh, Makoto Nagasaki, Hiroko Nakano, Keiko Morikawa;
Heterogeneity of cellular origins in human malignant lymphoma cell line derived from histo-monocytic lineage cells.
(In book chapter) Cellular, molecular, genetic approaches to immunodiagnosis and immunotherapy. 8th International conference on labeled antibodies, Tokyo, November 1985; Kano, Kyoichi & Mori, Shigeo & Sugisaki, Testuzo & Torisu, Motomichi (eds.); pp.373-380; Karger; Basel; Switzerland (1988)

PubMed=3335022
Michael C. Alley, Dominic A. Scudiero, Anne Monks, Miriam L. Hursey, Maciej J. Czerwinski, Donald L. Fine, Betty Jane Abbott, Joseph G. Mayo, Robert H. Shoemaker, Michael R. Boyd;
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.
Cancer Res. 48:589-601(1988)

PubMed=3422031; DOI=10.1182/blood.V71.1.242.242
Willard T. Dalton Jr., Michael John Ahearn, Kenneth B. McCredie, Emil J. Freireich, Sanford Alvin Stass, Jose M. Trujillo;
HL-60 cell line was derived from a patient with FAB-M2 and not FAB-M3.
Blood 71:242-247(1988)

PubMed=2545346
Alexander A. Hindenburg, James E. Gervasoni Jr., Sindu Krishna, Valerie J. Stewart, Michelle Rosado, Jose Lutzky, Kapil N. Bhalla, Michael A. Baker, Robert N. Taub;
Intracellular distribution and pharmacokinetics of daunorubicin in anthracycline-sensitive and -resistant HL-60 cells.
Cancer Res. 49:4607-4614(1989)

PubMed=1970118; DOI=10.1128/mcb.10.5.2154-2163.1990; PMCID=PMC360563
Steven J. Collins, Kent A. Robertson, LeMoyne Mueller;
Retinoic acid-induced granulocytic differentiation of HL-60 myeloid leukemia cells is mediated directly through the retinoic acid receptor (RAR-alpha).
Mol. Cell. Biol. 10:2154-2163(1990)

PubMed=2140233; DOI=10.1111/j.1440-1827.1990.tb01549.x
Akinobu Nakano, Takayuki Harada, Shigeru Morikawa, Yuzuru Kato;
Expression of leukocyte common antigen (CD45) on various human leukemia/lymphoma cell lines.
Acta Pathol. Jpn. 40:107-115(1990)

PubMed=1368402; DOI=10.1007/BF02540028
Benedicte Schumpp-Vonach, Ernst-Juergen Schlaeger;
Growth study of lactate and ammonia double-resistant clones of HL-60 cells.
Cytotechnology 8:39-44(1992)

PubMed=1574572; DOI=10.2307/3578273
Edward J. Dunphy, Michael A. Beckett, Lawrence H. Thompson, Ralph R. Weichselbaum;
Expression of the polymorphic human DNA repair gene XRCC1 does not correlate with radiosensitivity in the cells of human head and neck tumor cell lines.
Radiat. Res. 130:166-170(1992)

PubMed=8316623; DOI=10.2307/3578190
Helen Harrington Evans, Marlene Ricanati, Min-Fen Horng, Qiao-Yun Jiang, Jaroslav Mencl, Peggy Louise Olive;
DNA double-strand break rejoining deficiency in TK6 and other human B-lymphoblast cell lines.
Radiat. Res. 134:307-315(1993)

PubMed=8343448
Yasuhiko Kajigaya, Hideki Sasaki, Koichiro Ikuta, Shusuke Matsuyama, Yoko Hirabayashi, Tohru Inoue;
Serum-free culture for leukemia cells.
Hum. Cell 6:49-56(1993)

PubMed=7630190
Mu-Xiang Zhou, Lu-Bing Gu, Charles David James, J. He, Andrew M. Yeager, Stephen D. Smith, Harry W. Findley Jr.;
Homozygous deletions of the CDKN2 (MTS1/p16ink4) gene in cell lines established from children with acute lymphoblastic leukemia.
Leukemia 9:1159-1161(1995)

PubMed=8562479
Debabrata Banerjee, Heinz-Josef Lenz, Barbara Schnieders, David J. Manno, J.-F. Ju, C. Paul Spears, Daniel Hochhauser, Kathleen D. Danenberg, Peter V. Danenberg, Joseph Rocco Bertino;
Transfection of wild-type but not mutant p53 induces early monocytic differentiation in HL60 cells and increases their sensitivity to stress.
Cell Growth Differ. 6:1405-1413(1995)

PubMed=8558913
S. Morita, S. Tsuchiya, Hiromi Fujie, Masayuki Itano, Yoshiyuki Ohashi, Masayoshi Minegishi, Masue Imaizumi, M. Endo, Nagako Takano, Tasuke Konno;
Cell surface c-kit receptors in human leukemia cell lines and pediatric leukemia: selective preservation of c-kit expression on megakaryoblastic cell lines during adaptation to in vitro culture.
Leukemia 10:102-105(1996)

PubMed=9434637; DOI=10.1006/excr.1997.3813
Edward Harman Piepmeier, John E. Kalns, Kenneth M. McIntyre, Marian L. Lewis;
Prolonged weightlessness affects promyelocytic multidrug resistance.
Exp. Cell Res. 237:410-418(1997)

PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x; PMCID=PMC5921588
Noriko Hosoya, Akira Hangaishi, Seishi Ogawa, Kiyoshi Miyagawa, Kinuko Mitani, Yoshio Yazaki, Hisamaru Hirai;
Frameshift mutations of the hMSH6 gene in human leukemia cell lines.
Jpn. J. Cancer Res. 89:33-39(1998)

PubMed=9557624; DOI=10.1038/sj.leu.2400976
Letizia Mattii, Roberto Barale, Mario Petrini;
Use of the comet test in the evaluation of multidrug resistance of human cell lines.
Leukemia 12:627-632(1998)

PubMed=9607592
Jing-Fan Ju, Debabrata Banerjee, Heinz-Josef Lenz, Kathleen D. Danenberg, Thomas D. Schmittgen, C. Paul Spears, Axel H. Schonthal, David J. Manno, Daniel Hochhauser, Joseph Rocco Bertino, Peter V. Danenberg;
Restoration of wild-type p53 activity in p53-null HL-60 cells confers multidrug sensitivity.
Clin. Cancer Res. 4:1315-1322(1998)

PubMed=9737686; DOI=10.1038/sj.leu.2401112
Wen-Ji Zhang, Kazunori Ohnishi, Kazuyuki Shigeno, Shinya Fujisawa, Kensuke Naito, Satoki Nakamura, Kenzo Takeshita, Akihiro Takeshita, Ryuzo Ohno;
The induction of apoptosis and cell cycle arrest by arsenic trioxide in lymphoid neoplasms.
Leukemia 12:1383-1391(1998)

PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x; PMCID=PMC5921886
Jun Takizawa, Ritsuro Suzuki, Hiroyuki Kuroda, Atae Utsunomiya, Yoshitoyo Kagami, Tatsuroh Joh, Yoshifusa Aizawa, Ryuzo Ueda, Masao Seto;
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
Jpn. J. Cancer Res. 89:712-718(1998)

PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4
Kaoru Inoue, Takashi Kohno, Satoshi Takakura, Yasuhide Hayashi, Hideaki Mizoguchi, Jun Yokota;
Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.
Leuk. Res. 24:255-262(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1
Kaoru Inoue, Takashi Kohno, Satoshi Takakura, Yasuhide Hayashi, Hideaki Mizoguchi, Jun Yokota;
Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262.
Leuk. Res. 25:275-278(2001)

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
John R.W. Masters, Jim A. Thomson, Bernadette Daly-Burns, Yvonne A. Reid, Wilhelm Gerhard Dirks, Phil Packer, Lorraine H. Toji, Tadao Ohno, Hideyuki Tanabe, Colin Francis Arlett, Lloyd R. Kelland ...Show all 16 authors... , Maureen Harrison, Arvind K. Virmani, Timothy H. Ward, Karen L. Ayres, Paul G. Debenham; Show fewer authors
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

PubMed=12068308; DOI=10.1038/nature00766
Helen R. Davies, Graham Robert Bignell, Charles Cox, Philip J. Stephens, Sarah Edkins, Sheila Clegg, Jon W. Teague, Hayley Woffendin, Mathew J. Garnett, William Bottomley, Neil Davis ...Show all 52 authors... , Ed Dicks, Rebecca Ewing, Yvonne Floyd, Kristian Gray, Sarah Hall, Rachel Hawes, Jaime Hughes, Vivian Kosmidou, Andrew Menzies, Catherine Mould, Adrian Parker, Claire Stevens, Stephen Watt, Steven Hooper, Rebecca Wilson, Hiran Jayatilake, Barry Austin Gusterson, Colin S. Cooper, Janet M. Shipley, Darren Hargrave, Kathy Pritchard-Jones, Norman J. Maitland, Georgia Chenevix-Trench, Gregory J. Riggins, Darell Doty Bigner, Giuseppe Palmieri, Antonio Cossu, Adrienne M. Flanagan, Andrew Nicholson, Judy W.C. Ho, Suet Yi Leung, Siu Tsan Yuen, Barbara L. Weber, Hilliard Foster Seigler, Timothy L. Darrow, Hugh F. Paterson, Richard Marais, Christopher John Marshall, Richard Wooster, Michael Rudolf Stratton, P. Andrew Futreal; Show fewer authors
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=12661003; DOI=10.1002/gcc.10196
Susanne Seitz, Peter Wassmuth, Jens Plaschke, Hans Konrad Schackert, Uwe Karsten, Mauro F. Santibanez-Koref, Peter Michael Schlag, Siegfried Scherneck;
Identification of microsatellite instability and mismatch repair gene mutations in breast cancer cell lines.
Genes Chromosomes Cancer 37:29-35(2003)

PubMed=16120335; DOI=10.1016/S1567-7249(03)00010-2
Barbara C. Levin, Koren A. Holland, Diane K. Hancock, Michael Coble, Thomas J. Parsons, Laura J. Kienker, Diana W. Williams, MaryPat Jones, Kristy L. Richie;
Comparison of the complete mtDNA genome sequences of human cell lines -- HL-60 and GM10742A -- from individuals with pro-myelocytic leukemia and Leber hereditary optic neuropathy, respectively, and the inclusion of HL-60 in the NIST human mitochondrial DNA standard reference material -- SRM 2392-I.
Mitochondrion 2:387-400(2003)

PubMed=15843827; DOI=10.1038/sj.leu.2403749
Anna K. Hagstrom-Andersson, Patrik Eden, David Lindgren, Jens Nilsson, Carin Lassen, Jesper Heldrup, Magnus Fontes, Ake Borg, Felix Mitelman, Bertil Johansson, Mattias Hoglund, Thoas Fioretos;
Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
Leukemia 19:1042-1050(2005)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Hilmar Quentmeier, Roderick A.F. MacLeod, Margarete Zaborski, Hans Gunther Drexler;
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=16957166; DOI=10.1369/jhc.6A7001.2006; PMCID=PMC3958123
Ann-Catrin Andersson, Sara Stromberg, Helena Backvall, Caroline Kampf, Mathias Uhlen, Kenneth Wester, Fredrik Ponten;
Analysis of protein expression in cell microarrays: a tool for antibody-based proteomics.
J. Histochem. Cytochem. 54:1413-1423(2006)

PubMed=17088437; DOI=10.1158/1535-7163.MCT-06-0433; PMCID=PMC2705832
Ogechi N. Ikediobi, Helen R. Davies, Graham Robert Bignell, Sarah Edkins, Claire Stevens, Sarah O'Meara, Thomas Santarius, Tim Avis, Syd Barthorpe, Lisa Brackenbury, Gemma Buck ...Show all 49 authors... , Adam P. Butler, Jody Clements, Jennifer Cole, Ed Dicks, Simon Forbes, Kristian Gray, Kelly Halliday, Rachel Harrison, Katy Hills, Jonathan Hinton, Chris Hunter, Andy Jenkinson, David Jones, Vivian Kosmidou, Richard Lugg, Andrew Menzies, Tatiana Mironenko, Adrian Parker, Janet Perry, Keiran Martin Raine, David Richardson, Rebecca Shepherd, Alex Small, Raffaella Smith, Helen Solomon, Philip J. Stephens, Jon W. Teague, Calli Tofts, Jennifer Varian, Tony Webb, Sofie West, Sara Widaa, Andy Yates, William C. Reinhold, John N. Weinstein, Michael Rudolf Stratton, P. Andrew Futreal, Richard Wooster; Show fewer authors
Mutation analysis of 24 known cancer genes in the NCI-60 cell line set.
Mol. Cancer Ther. 5:2606-2612(2006)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22068913; DOI=10.1073/pnas.1111840108; PMCID=PMC3219108
Jean-Pierre Gillet, Anna Maria Calcagno, Sudhir Varma, Miguel Marino, Lisa J. Green, Meena I. Vora, Chirayu Patel, Josiah N. Orina, Tatiana A. Eliseeva, Vineet Singal, Raji Padmanabhan ...Show all 17 authors... , Ben Davidson, Ram Ganapathi, Anil K. Sood, Bo R. Rueda, Suresh V. Ambudkar, Michael Marc Gottesman; Show fewer authors
Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance.
Proc. Natl. Acad. Sci. U.S.A. 108:18708-18713(2011)

PubMed=22032829; DOI=10.1016/j.mrfmmm.2011.10.005
Yang Luan, Mieko Kogi, Palanisamy Rajaguru, Jin Ren, Teruhide Yamaguchi, Kazuhiro Suzuki, Takayoshi Suzuki;
Microarray analysis of responsible genes in increased growth rate in the subline of HL60 (HL60RG) cells.
Mutat. Res. 731:20-26(2012)

PubMed=22347499; DOI=10.1371/journal.pone.0031628; PMCID=PMC3276511
Xiao-Yang Ruan, Jean-Pierre A. Kocher, Yves Pommier, Hong-Fang Liu, William C. Reinhold;
Mass homozygotes accumulation in the NCI-60 cancer cell lines as compared to HapMap trios, and relation to fragile site location.
PLoS ONE 7:e31628.1-e31628.9(2012)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22944676; DOI=10.1515/hsz-2012-0195
Stefan O. Reinke, Marion Bayer, Markus Berger, Stephan Hinderlich, Veronique Blanchard;
The analysis of N-glycans of cell membrane proteins from human hematopoietic cell lines reveals distinctions in their pattern.
Biol. Chem. 393:731-747(2012)

PubMed=23955599; DOI=10.1038/ng.2731
Ayana Kon, Lee-Yung Shih, Masashi Minamino, Masashi Sanada, Yuichi Shiraishi, Yasunobu Nagata, Ken-ichi Yoshida, Yusuke Okuno, Masashige Bando, Ryuichiro Nakato, Shumpei Ishikawa ...Show all 41 authors... , Aiko Sato-Otsubo, Genta Nagae, Aiko Nishimoto, Claudia Haferlach, Daniel Nowak, Yusuke Sato, Tamara Alpermann, Masao Nagasaki, Teppei Shimamura, Hiroko Tanaka, Kenichi Chiba, Ryo Yamamoto, Tomoyuki Yamaguchi, Makoto Otsu, Naoshi Obara, Mamiko Sakata-Yanagimoto, Tsuyoshi Nakamaki, Ken Ishiyama, Florian Nolte, Wolf-Karsten Hofmann, Shuichi Miyawaki, Shigeru Chiba, Hiraku Mori, Hiromitsu Nakauchi, Harold Phillip Koeffler, Hiroyuki Aburatani, Torsten Haferlach, Katsuhiko Shirahige, Satoru Miyano, Seishi Ogawa; Show fewer authors
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.
Nat. Genet. 45:1232-1237(2013)

PubMed=24368162; DOI=10.1016/j.exphem.2013.12.004
Piyanuch Sripayap, Tadashi Nagai, Mitsuyo Uesawa, Hiroyuki Kobayashi, Tomonori Tsukahara, Ken Ohmine, Kazuo Muroi, Keiya Ozawa;
Mechanisms of resistance to azacitidine in human leukemia cell lines.
Exp. Hematol. 42:294-306.e2(2014)

PubMed=24670534; DOI=10.1371/journal.pone.0092047; PMCID=PMC3966786
Sudhir Varma, Yves Pommier, Margot Sunshine, John N. Weinstein, William C. Reinhold;
High resolution copy number variation data in the NCI-60 cancer cell lines from whole genome microarrays accessible through CellMiner.
PLoS ONE 9:e92047.1-e92047.15(2014)

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Glenn S. Cowley, Barbara A. Weir, Francisca Vazquez, Pablo Tamayo, Justine A. Scott, Scott Rusin, Alexandra East-Seletsky, Levi D. Ali, William F.J. Gerath, Sarah E. Pantel, Patrick Hall Lizotte ...Show all 40 authors... , Guo-Zhi Jiang, Jessica Hsiao, Aviad Tsherniak, Elizabeth Dwinell, Simon Aoyama, Michael Okamoto, William Harrington, Ellen T. Gelfand, Thomas M. Green, Mark J. Tomko, Shuba Gopal, Terence C. Wong, Hu-Bo Li, Sara Howell, Nicolas Stransky, Ted Liefeld, Dongkeun Jang, Jonathan Bistline, Barbara Hill Meyers, Scott Allen Armstrong, Kenneth Carl Anderson, Kimberly Stegmaier, Michael Reich, David Pellman, Jesse S. Boehm, Jill P. Mesirov, Todd Robert Golub, David E. Root, William Chun Hahn; Show fewer authors
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035.1-140035.12(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=25894527; DOI=10.1371/journal.pone.0121314; PMCID=PMC4404347
Damaris Bausch-Fluck, Andreas Hofmann, Thomas Bock, Andreas P. Frei, Ferdinando Cerciello, Andrea Jacobs, Hansjoerg Moest, Ulrich Omasits, Rebekah L. Gundry, Charles Yoon, Ralph Schiess ...Show all 20 authors... , Alexander Schmidt, Paulina Mirkowska, Anetta Svitorka Hartlova, Jennifer Eileen Van Eyk, Jean-Pierre Bourquin, Rudolf Aebersold, Kenneth R. Boheler, Peter W. Zandstra, Bernd Wollscheid; Show fewer authors
A mass spectrometric-derived cell surface protein atlas.
PLoS ONE 10:e0121314.1-e0121314.22(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28109323; DOI=10.1186/s13045-017-0396-0; PMCID=PMC5251306
Riccardo Masetti, Salvatore Nicola Bertuccio, Annalisa Astolfi, Francesca Chiarini, Annalisa Lonetti, Valentina Indio, Matilde De Luca, Jessica Bandini, Salvatore Serravalle, Monica Franzoni, Martina Pigazzi ...Show all 15 authors... , Alberto Maria Martelli, Giuseppe Basso, Franco Locatelli, Andrea Pession; Show fewer authors
Hh/Gli antagonist in acute myeloid leukemia with CBFA2T3-GLIS2 fusion gene.
J. Hematol. Oncol. 10:26.1-26.5(2017)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29491412; DOI=10.1038/s41388-018-0150-2; PMCID=PMC5955861
Daniel Gerlach, Ulrike Tontsch-Grunt, Anke Baum, Johannes Popow, Dirk Scharn, Marco H. Hofmann, Harald Engelhardt, Onur Kaya, Janina Beck, Norbert Schweifer, Thomas Gerstberger ...Show all 14 authors... , Johannes Zuber, Fabio Savarese, Norbert Kraut; Show fewer authors
The novel BET bromodomain inhibitor BI 894999 represses super-enhancer-associated transcription and synergizes with CDK9 inhibition in AML.
Oncogene 37:2687-2701(2018)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786
Kar-Tong Tan, Ling-Wen Ding, Qiao-Yang Sun, Zhen-Tang Lao, Wenwen Chien, Xi Ren, Jin-Fen Xiao, Xin-Yi Loh, Liang Xu, Michael Lill, Anand Mayakonda ...Show all 14 authors... , De-Chen Lin, Henry He Yang, Harold Phillip Koeffler; Show fewer authors
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940.1-940.13(2018)

PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144
Cord C. Uphoff, Claudia Pommerenke, Sabine A. Denkmann, Hans Gunther Drexler;
Screening human cell lines for viral infections applying RNA-Seq data analysis.
PLoS ONE 14:e0210404.1-e0210404.22(2019)

PubMed=30670178; DOI=10.1016/j.jcf.2018.06.007
Scott Jennings, Hang Pong Ng, Guo-Shun Wang;
Establishment of a DeltaF508-CF promyelocytic cell line for cystic fibrosis research and drug screening.
J. Cyst. Fibros. 18:44-53(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646
Hilmar Quentmeier, Claudia Pommerenke, Wilhelm Gerhard Dirks, Sonja Eberth, Max Koeppel, Roderick A.F. MacLeod, Stefan Nagel, Klaus G. Steube, Cord C. Uphoff, Hans Gunther Drexler;
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218.1-8218.14(2019)

PubMed=33389257; DOI=10.1007/s10096-020-04106-0; PMCID=PMC7778494
Nathalie Wurtz, Gwilherm Penant, Priscilla Jardot, Nathalie Duclos, Bernard La Scola;
Culture of SARS-CoV-2 in a panel of laboratory cell lines, permissivity, and differences in growth profile.
Eur. J. Clin. Microbiol. Infect. Dis. 40:477-484(2021)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

PubMed=36982453; DOI=10.3390/ijms24065377; PMCID=PMC10049680
Rafal Skopek, Malgorzata Palusinska, Katarzyna Kaczor-Keller, Rafal Pingwara, Anna Papierniak-Wygladala, Tino Schenk, Slawomir Lewicki, Artur Zelent, Lukasz Szymanski;
Choosing the right cell line for acute myeloid leukemia (AML) research.
Int. J. Mol. Sci. 24:5377.1-5377.34(2023)

Cross-references
Cell line collections (Providers) Abcam; ab282204 - Discontinued
AddexBio; C0003023/4977
ATCC; CCL-240
BCRC; 60027
BCRJ; 0104
CCTCC; GDC0027
CCTCC; GDC0028
CLS; 300209
DSMZ; ACC-3
ECACC; 98070106
ICLC; HTL95010
IZSLER; BS TCL 25
JCRB; IFO50022
JCRB; JCRB0085
JCRB; NIHS0086 - Discontinued
KCB; KCB 2014051YJ
KCLB; 10240
NCBI_Iran; C217
RCB; RCB0041
RCB; RCB3683
TKG; TKG 0345
Ubigene; YC-C058
Cell line databases/resources CLO; CLO_0003775
CLO; CLO_0050972
MCCL; MCC:0000195
CLDB; cl1682
CLDB; cl1684
CLDB; cl1685
CLDB; cl1686
CLDB; cl1687
CLDB; cl1688
CLDB; cl1689
CLDB; cl1690
CLDB; cl1691
CLDB; cl1693
cancercelllines; CVCL_0002
CCRID; 1101HUM-PUMC000037
CCRID; 1102HUM-NIFDC00098
CCRID; 3101HUMTCHu23
CCRID; 4201HUM-CCTCC00028
Cell_Model_Passport; SIDM00829
Cosmic-CLP; 905938
DepMap; ACH-000002
DSMZCellDive; ACC-3
IGRhCellID; HL60
LINCS_LDP; LCL-1054
Lonza; 64
SKY/M-FISH/CGH; 5609
TOKU-E; 1488
Anatomy/cell type resources BTO; BTO_0000738
Biological sample resources BioSample; SAMN01821559
BioSample; SAMN01821682
BioSample; SAMN03472768
BioSample; SAMN03473174
BioSample; SAMN10988245
ENCODE; ENCBS069ENC
ENCODE; ENCBS070ENC
ENCODE; ENCBS215JQI
ENCODE; ENCBS308XSW
ENCODE; ENCBS373UEY
ENCODE; ENCBS482VCU
ENCODE; ENCBS698WLF
ENCODE; ENCBS869DKF
ENCODE; ENCBS880XNW
CRISP screens repositories BioGRID_ORCS_Cell_line; 42
Chemistry resources ChEMBL-Cells; CHEMBL3307654
ChEMBL-Targets; CHEMBL383
GDSC; 905938
PharmacoDB; HL60_546_2019
PubChem_Cell_line; CVCL_0002
Encyclopedic resources Wikidata; Q5630035
Experimental variables resources EFO; EFO_0002793
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
FANTOM5_SSTAR; 10829-111D1
GEO; GSM50194
GEO; GSM50258
GEO; GSM213809
GEO; GSM236782
GEO; GSM236818
GEO; GSM472908
GEO; GSM472942
GEO; GSM482507
GEO; GSM545496
GEO; GSM545497
GEO; GSM743458
GEO; GSM749688
GEO; GSM749775
GEO; GSM750812
GEO; GSM799346
GEO; GSM799409
GEO; GSM838428
GEO; GSM838429
GEO; GSM838430
GEO; GSM838431
GEO; GSM887083
GEO; GSM888153
GEO; GSM945222
GEO; GSM945255
GEO; GSM1153417
GEO; GSM1181331
GEO; GSM1181348
GEO; GSM1374535
GEO; GSM1374536
GEO; GSM1446736
GEO; GSM1669883
GEO; GSM2716740
GEO; GSM2716741
GEO; GSM2716742
GEO; GSM2716743
GEO; GSM7701378
GEO; GSM7701379
Medical resources MeSH; D018922
Polymorphism and mutation databases Cosmic; 716179
Cosmic; 716190
Cosmic; 724817
Cosmic; 787433
Cosmic; 798224
Cosmic; 798665
Cosmic; 808506
Cosmic; 821043
Cosmic; 850380
Cosmic; 851996
Cosmic; 875866
Cosmic; 905938
Cosmic; 919116
Cosmic; 922161
Cosmic; 922683
Cosmic; 924049
Cosmic; 932769
Cosmic; 947366
Cosmic; 949099
Cosmic; 975252
Cosmic; 981578
Cosmic; 991557
Cosmic; 994170
Cosmic; 999724
Cosmic; 1012068
Cosmic; 1019836
Cosmic; 1037661
Cosmic; 1070693
Cosmic; 1078724
Cosmic; 1089519
Cosmic; 1092602
Cosmic; 1107177
Cosmic; 1127250
Cosmic; 1130234
Cosmic; 1168468
Cosmic; 1176580
Cosmic; 1181599
Cosmic; 1191695
Cosmic; 1192826
Cosmic; 1226863
Cosmic; 1281315
Cosmic; 1305337
Cosmic; 1308224
Cosmic; 1319549
Cosmic; 1451845
Cosmic; 1465966
Cosmic; 1523825
Cosmic; 1524830
Cosmic; 1582390
Cosmic; 1601062
Cosmic; 1604861
Cosmic; 1998444
Cosmic; 2036678
Cosmic; 2089652
Cosmic; 2131539
Cosmic; 2301565
Cosmic; 2306208
Cosmic; 2651387
IARC_TP53; 21372
IARC_TP53; 21731
LiGeA; CCLE_789
Progenetix; CVCL_0002
Proteomic databases PRIDE; PRD000345
PRIDE; PXD000589
PRIDE; PXD006421
PRIDE; PXD030304
PRIDE; PXD032942
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number52