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Cellosaurus HL-60/S4 (CVCL_II77)

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Cell line name HL-60/S4
Accession CVCL_II77
Resource Identification Initiative To cite this cell line use: HL-60/S4 (RRID:CVCL_II77)
Comments Population: Caucasian.
Characteristics: Differentiation to a granulocyte-like state can be induced by retinoic acid (RA).
Transformant: ChEBI; CHEBI_21759; N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
Omics: Genomics; DNA methylation analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute myeloid leukemia with maturation (NCIt: C7961)
Acute myeloblastic leukemia with maturation (ORDO: Orphanet_98834)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0002 (HL-60)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3306

Markers:
AmelogeninX
CSF1PO13,14
D5S81812
D7S82011,12
D13S3178,11
D16S53911
TH017
TPOX8,11
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=1737356
Mun-Fai Leung, John A. Sokoloski, Alan C. Sartorelli;
Changes in microtubules, microtubule-associated proteins, and intermediate filaments during the differentiation of HL-60 leukemia cells.
Cancer Res. 52:949-954(1992)

PubMed=31988093; DOI=10.1242/bio.044222; PMCID=PMC7044446
Enoch Boasiako Antwi, Ada Olins, Vladimir B. Teif, Matthias Bieg, Tobias Bauer, Zu-Guang Gu, Benedikt Brors, Roland Eils, Donald Olins, Naveed Ishaque;
Whole-genome fingerprint of the DNA methylome during chemically induced differentiation of the human AML cell line HL-60/S4.
Biol. Open 9:bio044222.1-bio044222.11(2020)

Cross-references
Cell line collections (Providers) ATCC; CRL-3306
Cell line databases/resources cancercelllines; CVCL_II77
Encyclopedic resources Wikidata; Q54889808
Entry history
Entry creation01-Dec-2016
Last entry update14-Aug-2025
Version number20