_____ _ _ / ____| | | | | | ___| | | ___ ___ __ _ _ _ _ __ _ _ ___ | | / _ \ | |/ _ \/ __|/ _` | | | | '__| | | / __| | |___| __/ | | (_) \__ \ (_| | |_| | | | |_| \__ \ \_____\___|_|_|\___/|___/\__,_|\__,_|_| \__,_|___/ This is the release notes for Cellosaurus version 48 of January 2024 1) Statistics 152231 cell lines (112768 human, 27420 mouse, 2879 rat) 809 species represented 112476 synonyms 453478 cross-references to 108 resources (cell line catalogs, databases, ontologies, etc.) 158453 references to 27418 distinct publications (papers, patents, theses, etc.) 13492 web links 8734 human, mouse and dog cell lines with STR profiles (from 856 distinct sources) 2434 NCIt and 1339 ORDO (Orphanet) disease terms cited 831 UBERON and 258 CL terms cited Since release 47 of October 2023: 3553 entries were created 15985 entries were updated 2) Changes in the DR lines 2a) Cross-references were added to the cell line elements in the BioGRID Open Repository of CRISPR Screens (BioGRID_ORCS) Corresponding entry in the file cellosaurus_xrefs.txt: Abbrev: BioGRID_ORCS_Cell_line Name : BioGRID Open Repository of CRISPR Screens cell lines Server: https://orcs.thebiogrid.org/ Db_URL: https://orcs.thebiogrid.org/Search?searchType=10&search=%s&organism=all Term. : No Cat : CRISP screens repositories // Example: DR BioGRID_ORCS_Cell_line; 95 2b) Cross-references were added to the Developmental Studies Hybridoma Bank (DSHB). Prevously web links were provided to this resources, but we upgraded them to cross-references. Corresponding entry in the file cellosaurus_xrefs.txt: Abbrev: DSHB Name : Developmental Studies Hybridoma Bank Server: https://dshb.biology.uiowa.edu/ Db_URL: https://dshb.biology.uiowa.edu/%s Term. : No Cat : Cell line collections (Providers) // Example: DR DSHB; 12-120-94-6 3) Changes in the XML file Six new elements have been created: knockout-cell microsatellite-instability monoclonal-antibody-isotype monoclonal-antibody-target resistance transformant They allow a structured representation of the information which was formerly represented as the text comments: "Knockout cell", "Microsatellite instability", "Monoclonal antibody isotype", "Monoclonal antibody target", "Selected for resistance to" and "Transformant". ---------------------------------------- Amos Bairoch CALIPHO group; neXtProt project SIB - Swiss Institute of Bioinformatics Geneva; Switzerland ----------------------------------------