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Cellosaurus - SARS-CoV-2 relevant information

Table of contents

(A) Cell lines that can be used to grow SARS-CoV-2
(B) Engineered cell lines useful for SARS-CoV-2 research
(C) Cell lines shown to be not suitable to grow SARS-CoV-2
(D) Cell lines used in COVID-19 vaccine production
(E) Hybridomas producing mAb against SARS-CoV-2 proteins

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Version 11 of December 14, 2022

(A) Cell lines that can be used to grow SARS-CoV-2

The information concerning the susceptibility of cell lines to SARS-Cov-2 infection is now annotated in the relevant Cellosaurus entries
See also the review of Kumar et al (PubMed=33550034).

(B) Engineered cell lines useful for SARS-CoV-2 research

These are mostly cell lines that are expressing genes (such as ACE2) that are useful to study the entry of SARS-CoV-2 into cells or cell lines that over-express some of the SARS-CoV-2 viral proteins.

To help retrieve these cell lines, we have created a specific 'group': SARS-CoV-2 research cell line


(C) Cell lines shown to be not suitable to grow SARS-CoV-2

This information is now annotated in the relevant Cellosaurus entries: Click here

(D) Cell lines used in COVID-19 vaccine production

A number of SARS-CoV-2 vaccines make use of cell lines to either grow an engineered adenovirus vector, an attenuated SARS-CoV-2 virus or a recombinant spike protein that will directly elicit an immune response. For some vaccines in development, we are not sure of the cell line used for their production, however we have some clue that:
It must be noted that, as described in a specific FAQ, vaccines do NOT contain cell lines.

For a non-controversial overview of the controversy on the use of human fetal cell lines for COVID-19 vaccine development see the following University of Nebraska Medical Center page.

(E) Hybridomas producing mAB against SARS-CoV-2 proteins

These are hybridomas raised against:
1) The spike protein (S) [UniProtKB; P0DTC2]
To retrieve those annotated in the Cellosaurus: Click here

2) The nucleoprotein (N) [UniProtKB; P0DTC9]
To retrieve those annotated in the Cellosaurus: Click here