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Cellosaurus PER.C6 TetR (CVCL_A7ME)

[Text version]
Cell line name PER.C6 TetR
Accession CVCL_A7ME
Resource Identification Initiative To cite this cell line use: PER.C6 TetR (RRID:CVCL_A7ME)
Comments Group: Vaccine production cell line.
From: Johnson & Johnson Janssen; Beerse; Belgium.
Biotechnology: Used for the production of the Janssen SARS-CoV-2 (COVID-19) vaccine (Trade name: Ad26.COV2.S) (DrugBank=DB15857). In the context of the vaccine production, the tetR repressor blocks the expression of the SARS-CoV-2 spike protein gene during production of the recombinant adenoviral vector, thereby optimising vector production.
Transfected with: UniProtKB; P04483; Escherichia coli Tn10 tetR.
Transformant: NCBI_TaxID; 28285; Adenovirus 5 [Note=E1].
Derived from site: In situ; Fetal eye, retina; UBERON=UBERON_0003072.
Cell type: Retinoblast; CL=CL_4023129.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_G704 (PER.C6)
Sex of cell Sex unspecified
Age at sampling 18FW
Category Transformed cell line
Web pages https://www.ema.europa.eu/en/documents/assessment-report/covid-19-vaccine-janssen-epar-public-assessment-report_en.pdf
Encyclopedic resources Wikidata; Q107116656
Entry history
Entry creation20-May-2021
Last entry update30-Jan-2024
Version number8