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Cellosaurus PER.C6 (CVCL_G704)

[Text version]
Cell line name PER.C6
Synonyms Per.C6; PER C6; PERC6; PerC6; Perc6; PER cell clone 6
Accession CVCL_G704
Resource Identification Initiative To cite this cell line use: PER.C6 (RRID:CVCL_G704)
Comments Group: Patented cell line.
Group: Vaccine production cell line.
From: Johnson & Johnson Janssen (originally Crucell); Beerse; Belgium.
Registration: International Depositary Authority, European Collection of Cell Cultures (ECACC); 96022940.
Biotechnology: Used for the production of follitropin delta (Trade name: Rekovelle).
Virology: Supports replication of all three poliovirus serotypes (PubMed=23123018).
Transformant: NCBI_TaxID; 28285; Human adenovirus C serotype 5 (Note=E1A/E1B).
Misspelling: Per.Co6; Note=Occasionally.
Derived from site: In situ; Fetal eye, retina; UBERON=UBERON_0003072.
Cell type: Retinoblast; CL=CL_4023129.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_A9E7 (HP PER.C6)CVCL_A7ME (PER.C6 TetR)
Originate from same individual CVCL_1K15 ! 911
Sex of cell Sex unspecified
Age at sampling 18FW
Category Transformed cell line
Web pages Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/p/cell-lines-detail-452.html
Provider; Crucell; -; https://web.archive.org/web/20121219090924/http://www.dsm.com/en_US/downloads/dpp/PER.C6_Brochure.pdf
Provider; Crucell; -; https://web.archive.org/web/20140721200546/http://www.crucell.com/page/downloads/Factsheet_PER.C6_Technology.pdf
Publications

PubMed=9741429; DOI=10.1089/hum.1998.9.13-1909
Frits Jacobus Fallaux, Abraham Bout, Ietje van der Velde, Diana J.M. van den Wollenberg, Kathleen M. Hehir, Jesse Keegan, Crys Auger, Steve J. Cramer, Hans van Ormondt, Alex Jan van der Eb, Dinko Valerio, Rob C. Hoeben;
New helper cells and matched early region 1-deleted adenovirus vectors prevent generation of replication-competent adenoviruses.
Hum. Gene Ther. 9:1909-1917(1998)

PubMed=11257414; DOI=10.1016/S0264-410X(00)00508-9
Maria Grazia Pau, Carla Ophorst, Martin H. Koldijk, Govert Johan Schouten, Majid Mehtali, Fons G.C.M. Uytdehaag;
The human cell line PER.C6 provides a new manufacturing system for the production of influenza vaccines.
Vaccine 19:2716-2721(2001)

Patent=US6602706
Frits Jacobus Fallaux, Rob C. Hoeben, Alex Jan van der Eb, Abraham Bout, Dinko Valerio;
Packaging systems for human recombinant adenovirus to be used in gene therapy.
Patent number US6602706, 05-Aug-2003

PubMed=16566444
John A. Lewis, Eugene L. Brown, Paul A. Duncan;
Approaches to the release of a master cell bank of PER.C6 cells; a novel cell substrate for the manufacture of human vaccines.
Dev. Biol. (Basel) 123:165-176(2006)

PubMed=18052336; DOI=10.1021/bp070258u
Marina Berdichevsky, Marie-Pierre Gentile, Benjamin Hughes, Peter Meis, Joseph Peltier, Ilse Blumentals, John Aunins, Nedim Emil Altaras;
Establishment of higher passage PER.C6 cells for adenovirus manufacture.
Biotechnol. Prog. 24:158-165(2008)

PubMed=23123018; DOI=10.1016/j.vaccine.2012.10.070
Barbara P. Sanders, Diana Edo-Matas, Jerome H.H.V. Custers, Martin H. Koldijk, Vincent N.A. Klaren, Marije Turk, Alfred Luitjens, Wilfried A.M. Bakker, Fons G.C.M. Uytdehaag, Jaap Goudsmit, John A. Lewis, Hanneke Schuitemaker;
PER.C6 cells as a serum-free suspension cell platform for the production of high titer poliovirus: a potential low cost of goods option for world supply of inactivated poliovirus vaccine.
Vaccine 31:850-856(2013)

PubMed=25903999; DOI=10.1002/biot.201400388
Yvonne Genzel;
Designing cell lines for viral vaccine production: where do we stand?
Biotechnol. J. 10:728-740(2015)

Patent=US9469865
Gerben Meile Zijlstra, Robert Patrick Hof, Jacob Schilder;
Process for the culturing of cells.
Patent number US9469865, 18-Oct-2016

PubMed=28450423; DOI=10.1530/EC-17-0067; PMCID=PMC5510450
Wolfgang Koechling, Daniel Plaksin, Glenn E. Croston, Janni Vikkelso Jeppesen, Kirsten T. Macklon, Claus Yding Andersen;
Comparative pharmacology of a new recombinant FSH expressed by a human cell line.
Endocr. Connect. 6:297-305(2017)

Cross-references
Cell line databases/resources FCS-free; 39-13-46-1-8-11
Encyclopedic resources Wikidata; Q54947225
Experimental variables resources EFO; EFO_0022685
Entry history
Entry creation11-Feb-2013
Last entry update14-Aug-2025
Version number25