ID   PER.C6
AC   CVCL_G704
SY   Per.C6; PER C6; PERC6; PerC6; Perc6; PER cell clone 6
DR   EFO; EFO_0022685
DR   FCS-free; 39-13-46-1-8-11
DR   Wikidata; Q54947225
RX   Patent=US6602706;
RX   Patent=US9469865;
RX   PubMed=9741429;
RX   PubMed=11257414;
RX   PubMed=16566444;
RX   PubMed=18052336;
RX   PubMed=23123018;
RX   PubMed=25903999;
RX   PubMed=28450423;
WW   Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/p/cell-lines-detail-452.html
WW   Provider; Crucell; -; https://web.archive.org/web/20121219090924/http://www.dsm.com/en_US/downloads/dpp/PER.C6_Brochure.pdf
WW   Provider; Crucell; -; https://web.archive.org/web/20140721200546/http://www.crucell.com/page/downloads/Factsheet_PER.C6_Technology.pdf
CC   Group: Patented cell line.
CC   Group: Vaccine production cell line.
CC   From: Johnson & Johnson Janssen (originally Crucell); Beerse; Belgium.
CC   Registration: International Depositary Authority, European Collection of Cell Cultures (ECACC); 96022940.
CC   Biotechnology: Used for the production of follitropin delta (Trade name: Rekovelle).
CC   Virology: Supports replication of all three poliovirus serotypes (PubMed=23123018).
CC   Transformant: NCBI_TaxID; 28285; Human adenovirus C serotype 5 (Note=E1A/E1B).
CC   Misspelling: Per.Co6; Note=Occasionally.
CC   Derived from site: In situ; Fetal eye, retina; UBERON=UBERON_0003072.
CC   Cell type: Retinoblast; CL=CL_4023129.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_1K15 ! 911
SX   Sex unspecified
AG   18FW
CA   Transformed cell line
DT   Created: 11-02-13; Last updated: 14-08-25; Version: 25
CH   CVCL_A9E7 ! HP PER.C6
CH   CVCL_A7ME ! PER.C6 TetR
//
RX   Patent=US6602706;
RA   Fallaux, Frits Jacobus
RA   Hoeben, Rob C.
RA   van der Eb, Alex Jan
RA   Bout, Abraham
RA   Valerio, Dinko
RT   "Packaging systems for human recombinant adenovirus to be used in gene
RT   therapy.";
RL   Patent number US6602706, 05-Aug-2003.
//
RX   PubMed=9741429; DOI=10.1089/hum.1998.9.13-1909;
RA   Fallaux, Frits Jacobus
RA   Bout, Abraham
RA   van der Velde, Ietje
RA   van den Wollenberg, Diana J.M.
RA   Hehir, Kathleen M.
RA   Keegan, Jesse
RA   Auger, Crys
RA   Cramer, Steve J.
RA   van Ormondt, Hans
RA   van der Eb, Alex Jan
RA   Valerio, Dinko
RA   Hoeben, Rob C.
RT   "New helper cells and matched early region 1-deleted adenovirus
RT   vectors prevent generation of replication-competent adenoviruses.";
RL   Hum. Gene Ther. 9:1909-1917(1998).
//
RX   PubMed=11257414; DOI=10.1016/S0264-410X(00)00508-9;
RA   Pau, Maria Grazia
RA   Ophorst, Carla
RA   Koldijk, Martin H.
RA   Schouten, Govert Johan
RA   Mehtali, Majid
RA   Uytdehaag, Fons G.C.M.
RT   "The human cell line PER.C6 provides a new manufacturing system for
RT   the production of influenza vaccines.";
RL   Vaccine 19:2716-2721(2001).
//
RX   PubMed=25903999; DOI=10.1002/biot.201400388;
RA   Genzel, Yvonne
RT   "Designing cell lines for viral vaccine production: where do we
RT   stand?";
RL   Biotechnol. J. 10:728-740(2015).
//
RX   PubMed=18052336; DOI=10.1021/bp070258u;
RA   Berdichevsky, Marina
RA   Gentile, Marie-Pierre
RA   Hughes, Benjamin
RA   Meis, Peter
RA   Peltier, Joseph
RA   Blumentals, Ilse
RA   Aunins, John
RA   Altaras, Nedim Emil
RT   "Establishment of higher passage PER.C6 cells for adenovirus
RT   manufacture.";
RL   Biotechnol. Prog. 24:158-165(2008).
//
RX   PubMed=23123018; DOI=10.1016/j.vaccine.2012.10.070;
RA   Sanders, Barbara P.
RA   Edo-Matas, Diana
RA   Custers, Jerome H.H.V.
RA   Koldijk, Martin H.
RA   Klaren, Vincent N.A.
RA   Turk, Marije
RA   Luitjens, Alfred
RA   Bakker, Wilfried A.M.
RA   Uytdehaag, Fons G.C.M.
RA   Goudsmit, Jaap
RA   Lewis, John A.
RA   Schuitemaker, Hanneke
RT   "PER.C6 cells as a serum-free suspension cell platform for the
RT   production of high titer poliovirus: a potential low cost of goods
RT   option for world supply of inactivated poliovirus vaccine.";
RL   Vaccine 31:850-856(2013).
//
RX   Patent=US9469865;
RA   Zijlstra, Gerben Meile
RA   Hof, Robert Patrick
RA   Schilder, Jacob
RT   "Process for the culturing of cells.";
RL   Patent number US9469865, 18-Oct-2016.
//
RX   PubMed=28450423; DOI=10.1530/EC-17-0067; PMCID=PMC5510450;
RA   Koechling, Wolfgang
RA   Plaksin, Daniel
RA   Croston, Glenn E.
RA   Jeppesen, Janni Vikkelso
RA   Macklon, Kirsten T.
RA   Andersen, Claus Yding
RT   "Comparative pharmacology of a new recombinant FSH expressed by a
RT   human cell line.";
RL   Endocr. Connect. 6:297-305(2017).
//
RX   PubMed=16566444;
RA   Lewis, John A.
RA   Brown, Eugene L.
RA   Duncan, Paul A.
RT   "Approaches to the release of a master cell bank of PER.C6 cells; a
RT   novel cell substrate for the manufacture of human vaccines.";
RL   Dev. Biol. (Basel) 123:165-176(2006).
//