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Cellosaurus MA-104 (CVCL_3845)

[Text version]
Cell line name MA-104
Synonyms Ma-104; MA 104; MA104; Microbiological Associates-104
Accession CVCL_3845
Resource Identification Initiative To cite this cell line use: MA-104 (RRID:CVCL_3845)
Comments Group: Non-human primate cell line.
Problematic cell line: Misidentified. Originally thought to be of Rhesus macaque origin but found to be from African Green monkey (PubMed=4043530; PubMed=20143388) and more precisely from Chlorocebus pygerythrus (PubMed=34737324).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00077.
Virology: Susceptible to infection by many viruses (arboviruses, reoviruses, rotaviruses, etc.).
Virology: Susceptible to infection by SARS coronavirus (SARS-CoV). Produces a lytic infection (PubMed=15731278; PubMed=16494729).
Virology: Susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=33389257).
Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
Cell type: Epithelial cell of kidney; CL=CL_0002518.
Species of origin Chlorocebus pygerythrus (Vervet monkey) (Cercopithecus pygerythrus) (NCBI Taxonomy: 60710)
Hierarchy Children:
CVCL_1K12 (9009B)CVCL_A0XU (CL2621)CVCL_3846 (MA-104 Clone 1)
CVCL_4540 (MARC-145)CVCL_3774 (PSP-36)
Sex of cell Sex unspecified
Age at sampling Fetus
Category Spontaneously immortalized cell line
Web pages Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/ma-104-atcc-crl-2378
Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/m/cell-lines-detail-391.html
Publications

PubMed=4626908; DOI=10.1128/am.24.1.62-69.1972; PMCID=PMC380548
Martin G. Myers, Monroe Mortimer Vincent, Sally A. Hensen, Nicola Michael Tauraso;
Problems in the laboratory isolation of simian hemorrhagic fever viruses and isolation of the agent responsible for the Sussex/69 epizootic.
Appl. Microbiol. 24:62-69(1972)

PubMed=4043530
A.M. Whitaker, C.J. Hayward;
The characterization of three monkey kidney cell lines.
Dev. Biol. Stand. 60:125-131(1985)

PubMed=15731278; DOI=10.1128/JVI.79.6.3846-3850.2005; PMCID=PMC1075706
Eric C. Mossel, Cheng Huang, Krishna Narayanan, Shinji Makino, Robert B. Tesh, Clarence James Peters;
Exogenous ACE2 expression allows refractory cell lines to support severe acute respiratory syndrome coronavirus replication.
J. Virol. 79:3846-3850(2005)

PubMed=16494729; DOI=10.3201/eid1201.050496; PMCID=PMC3291385
Matthew Kaye, Julian Druce, Thomas Tran, Renata Kostecki, Doris Chibo, Jessica Morris, Mike Catton, Chris Birch;
SARS-associated coronavirus replication in cell lines.
Emerg. Infect. Dis. 12:128-133(2006)

PubMed=19941903; DOI=10.1016/j.jviromet.2009.11.022
Axel Karger, Barbara Bettin, Matthias Lenk, Thomas Christoph Mettenleiter;
Rapid characterisation of cell cultures by matrix-assisted laser desorption/ionisation mass spectrometric typing.
J. Virol. Methods 164:116-121(2010)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=26235236; DOI=10.1016/j.jviromet.2015.07.016
Peter H. Otto, Jochen Reetz, Werner Eichhorn, Werner Herbst, Mandy C. Elschner;
Isolation and propagation of the animal rotaviruses in MA-104 cells -- 30 years of practical experience.
J. Virol. Methods 223:88-95(2015)

PubMed=28046048; DOI=10.1371/journal.pone.0169391; PMCID=PMC5207746
Silvia Dotti, Tina Lombardo, Riccardo Villa, Andrea Cacciamali, Cinzia Zanotti, Nadia Andrea Andreani, Stefano Cinotti, Maura Ferrari;
Transformation and tumorigenicity testing of simian cell lines and evaluation of poliovirus replication.
PLoS ONE 12:e0169391.1-e0169391.13(2017)

PubMed=33389257; DOI=10.1007/s10096-020-04106-0; PMCID=PMC7778494
Nathalie Wurtz, Gwilherm Penant, Priscilla Jardot, Nathalie Duclos, Bernard La Scola;
Culture of SARS-CoV-2 in a panel of laboratory cell lines, permissivity, and differences in growth profile.
Eur. J. Clin. Microbiol. Infect. Dis. 40:477-484(2021)

PubMed=34737324; DOI=10.1038/s41598-021-00779-5; PMCID=PMC8569163
Oliver Lung, Rebecca C. Candlish, Michelle Nebroski, Peter Kruckiewicz, Cody Buchanan, Mariko Moniwa;
High-throughput sequencing for species authentication and contamination detection of 63 cell lines.
Sci. Rep. 11:21657.1-21657.9(2021)

Cross-references
Cell line collections (Providers) ATCC; CRL-2378 - Discontinued
BCRJ; 0157
CCLV; CCLV-RIE 0142
CCTCC; GDC0041
CLS; 305007
ECACC; 85102918
IZSLER; BS CL 61
KCB; KCB 2010001YJ
NCBI_Iran; C486
RCB; RCB0994
Cell line databases/resources CLO; CLO_0007492
CLO; CLO_0007494
CLO; CLO_0051423
CLDB; cl3324
CLDB; cl3325
CLDB; cl3326
CLDB; cl3327
CCRID; 4201MON-CCTCC00041
Anatomy/cell type resources BTO; BTO_0004983
Biological sample resources BioSample; SAMN03152038
Encyclopedic resources Wikidata; Q54903682
Experimental variables resources EFO; EFO_0022811
Gene expression databases GEO; GSM758845
GEO; GSM758846
GEO; GSM758847
GEO; GSM758848
GEO; GSM758849
GEO; GSM758850
GEO; GSM758851
GEO; GSM758852
GEO; GSM758853
GEO; GSM758854
GEO; GSM758855
GEO; GSM758856
GEO; GSM758857
GEO; GSM758858
GEO; GSM758859
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number34