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Cellosaurus MARC-145 (CVCL_4540)

[Text version]
Cell line name MARC-145
Synonyms Marc-145; MARC 145; Marc 145; MARC145; Marc145; Meat Animal Research Center-145
Accession CVCL_4540
Resource Identification Initiative To cite this cell line use: MARC-145 (RRID:CVCL_4540)
Comments Group: Non-human primate cell line.
Group: Patented cell line.
Problematic cell line: Misidentified. Parent cell line (MA-104) has been shown to be from African Green monkey instead of Rhesus macaque.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00621.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-12219.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-12230.
Virology: Highly susceptible to infection by porcine reproductive and respiratory syndrome virus (PRRSV).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
Cell type: Epithelial cell of kidney; CL=CL_0002518.
Species of origin Chlorocebus pygerythrus (Vervet monkey) (Cercopithecus pygerythrus) (NCBI Taxonomy: 60710)
Hierarchy Parent: CVCL_3845 (MA-104)
Children:
CVCL_1T05 (LN 14832)CVCL_B6C8 (MARC-145 PBD-1+EGFP clone 9/D6)CVCL_VG41 (MARC-145 pig CD163)
CVCL_HA70 (MARC-Nsp11)
Sex of cell Sex unspecified
Age at sampling Fetus
Category Spontaneously immortalized cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=8257302; DOI=10.1007/BF01313785
Hyun Soo Kim, Jimmy Kwang, In J. Yoon, Han Soo Joo, Mervin L. Frey;
Enhanced replication of porcine reproductive and respiratory syndrome (PRRS) virus in a homogeneous subpopulation of MA-104 cell line.
Arch. Virol. 133:477-483(1993)

Patent=US5690940
Han Soo Joo;
Low pathogencity PRRS live virus vaccines and methods of preparation thereof.
Patent number US5690940, 25-Nov-1997

PubMed=17081295; DOI=10.1186/1743-422X-3-90; PMCID=PMC1635561
William A. Cafruny, Richard G. Duman, Grace H.W. Wong, Suleman Said, Pamela Ward-Demo, Raymond Robert Richard Rowland, Eric A. Nelson;
Porcine reproductive and respiratory syndrome virus (PRRSV) infection spreads by cell-to-cell transfer in cultured MARC-145 cells, is dependent on an intact cytoskeleton, and is suppressed by drug-targeting of cell permissiveness to virus infection.
Virol. J. 3:90.1-90.17(2006)

PubMed=23148668; DOI=10.1186/1743-422X-9-267; PMCID=PMC3546013
Chantale Provost, Jian-Jun Jia, Nedzad Music, Cynthia Levesque, Marie-Eve Lebel, Jerome Raphael Etienne del Castillo, Mario Jacques, Carl A. Gagnon;
Identification of a new cell line permissive to porcine reproductive and respiratory syndrome virus infection and replication which is phenotypically distinct from MARC-145 cell line.
Virol. J. 9:267.1-267.14(2012)

PubMed=28046048; DOI=10.1371/journal.pone.0169391; PMCID=PMC5207746
Silvia Dotti, Tina Lombardo, Riccardo Villa, Andrea Cacciamali, Cinzia Zanotti, Nadia Andrea Andreani, Stefano Cinotti, Maura Ferrari;
Transformation and tumorigenicity testing of simian cell lines and evaluation of poliovirus replication.
PLoS ONE 12:e0169391.1-e0169391.13(2017)

PubMed=29682543; DOI=10.1155/2018/4315861; PMCID=PMC5841097
Xiang-Ju Wu, Jing Qi, Xiao-Yan Cong, Lei Chen, Yue Hu, Dong-Wan Yoo, Gui-Sheng Wang, Fu-Lin Tian, Feng Li, Wen-Bo Sun, Zhi Chen ...Show all 17 authors... , Li-Hui Guo, Jia-Qiang Wu, Jun Li, Jin-Bao Wang, Xiao-Min Zhao, Yi-Jun Du; Show fewer authors
Establishment and characterization of a high and stable porcine CD163-expressing MARC-145 cell line.
BioMed Res. Int. 2018:4315861.1-4315861.9(2018)

PubMed=33268540; DOI=10.1128/jcm.01757-20; PMCID=PMC8106717
Wannarat Yim-im, Hai-Yan Huang, Jie Park, Chong Wang, Gabriela Calzada-Nova, Phillip Gauger, Karen Harmon, Rodger Main, Jian-Qiang Zhang;
Comparison of ZMAC and MARC-145 cell lines for improving porcine reproductive and respiratory syndrome virus isolation from clinical samples.
J. Clin. Microbiol. 59:e01757.20.1-e01757.20.15(2021)

PubMed=34205087; DOI=10.3390/vaccines9060594; PMCID=PMC8229515
Jie-Xiong Xie, Nick Vereecke, Sebastiaan Theuns, Da-Young Oh, Nathalie Vanderheijden, Ivan Trus, Jannes Sauer, Philip Vyt, Caroline Bonckaert, Christian Lalonde, Chantale Provost ...Show all 13 authors... , Carl A. Gagnon, Hans J. Nauwynck; Show fewer authors
Comparison of primary virus isolation in pulmonary alveolar macrophages and four different continuous cell lines for type 1 and type 2 porcine reproductive and respiratory syndrome virus.
Vaccines (Basel) 9:594.1-594.13(2021)

PubMed=34737324; DOI=10.1038/s41598-021-00779-5; PMCID=PMC8569163
Oliver Lung, Rebecca C. Candlish, Michelle Nebroski, Peter Kruckiewicz, Cody Buchanan, Mariko Moniwa;
High-throughput sequencing for species authentication and contamination detection of 63 cell lines.
Sci. Rep. 11:21657.1-21657.9(2021)

Cross-references
Cell line collections (Providers) CCLV; CCLV-RIE 0277
CLS; 305006
IZSLER; BS CL 127
KCB; KCB 200801YJ
Cell line databases/resources CLO; CLO_0007536
CLDB; cl5226
CCRID; 5301MON-KCB08001YJ
Anatomy/cell type resources BTO; BTO_0006549
Encyclopedic resources Wikidata; Q54904021
Gene expression databases GEO; GSM1263300
GEO; GSM1263301
GEO; GSM1263302
GEO; GSM1263303
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number25