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Cellosaurus MARC-145 (CVCL_4540)

[Text version]
Cell line name MARC-145
Synonyms Marc-145; MARC 145; Marc 145; MARC145; Marc145; Meat Animal Research Center-145
Accession CVCL_4540
Resource Identification Initiative To cite this cell line use: MARC-145 (RRID:CVCL_4540)
Comments Group: Non-human primate cell line.
Group: Patented cell line.
Problematic cell line: Misidentified. Parent cell line (MA-104) has been shown to be from African Green monkey instead of Rhesus macaque.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00621.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-12219.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-12230.
Virology: Highly susceptible to infection by porcine reproductive and respiratory syndrome virus (PRRSV).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
Species of origin Chlorocebus pygerythrus (Vervet monkey) (Cercopithecus pygerythrus) (NCBI Taxonomy: 60710)
Hierarchy Parent: CVCL_3845 (MA-104)
CVCL_1T05 (LN 14832)CVCL_B6C8 (MARC-145 PBD-1+EGFP clone 9/D6)CVCL_VG41 (MARC-145 pig CD163)
CVCL_HA70 (MARC-Nsp11)
Sex of cell Sex unspecified
Age at sampling Fetus
Category Spontaneously immortalized cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx

PubMed=8257302; DOI=10.1007/BF01313785
Kim H.S., Kwang J., Yoon I.J., Joo H.S., Frey M.L.
Enhanced replication of porcine reproductive and respiratory syndrome (PRRS) virus in a homogeneous subpopulation of MA-104 cell line.
Arch. Virol. 133:477-483(1993)

Joo H.S.
Low pathogencity PRRS live virus vaccines and methods of preparation thereof.
Patent number US5690940, 25-Nov-1997

PubMed=17081295; DOI=10.1186/1743-422X-3-90
Cafruny W.A., Duman R.G., Wong G.H.W., Said S., Ward-Demo P., Rowland R.R.R., Nelson E.A.
Porcine reproductive and respiratory syndrome virus (PRRSV) infection spreads by cell-to-cell transfer in cultured MARC-145 cells, is dependent on an intact cytoskeleton, and is suppressed by drug-targeting of cell permissiveness to virus infection.
Virol. J. 3:90.1-90.17(2006)

PubMed=23148668; DOI=10.1186/1743-422X-9-267
Provost C., Jia J.-J., Music N., Levesque C., Lebel M.-E., del Castillo J.R.E., Jacques M., Gagnon C.A.
Identification of a new cell line permissive to porcine reproductive and respiratory syndrome virus infection and replication which is phenotypically distinct from MARC-145 cell line.
Virol. J. 9:267.1-267.14(2012)

PubMed=28046048; DOI=10.1371/journal.pone.0169391
Dotti S., Lombardo T., Villa R., Cacciamali A., Zanotti C., Andreani N.A., Cinotti S., Ferrari M.
Transformation and tumorigenicity testing of simian cell lines and evaluation of poliovirus replication.
PLoS ONE 12:E0169391-E0169391(2017)

PubMed=29682543; DOI=10.1155/2018/4315861
Wu X.-J., Qi J., Cong X.-Y., Chen L., Hu Y., Yoo D.-W., Wang G.-S., Tian F.-L., Li F., Sun W.-B., Chen Z., Guo L.-H., Wu J.-Q., Li J., Wang J.-B., Zhao X.-M., Du Y.-J.
Establishment and characterization of a high and stable porcine CD163-expressing MARC-145 cell line.
BioMed Res. Int. 2018:4315861.1-4315861.9(2018)

PubMed=33268540; DOI=10.1128/jcm.01757-20
Yim-im W., Huang H.-Y., Park J., Wang C., Calzada-Nova G., Gauger P., Harmon K., Main R., Zhang J.-Q.
Comparison of ZMAC and MARC-145 cell lines for improving porcine reproductive and respiratory syndrome virus isolation from clinical samples.
J. Clin. Microbiol. 59:e01757.20.1-e01757.20.15(2021)

PubMed=34205087; DOI=10.3390/vaccines9060594
Xie J.-X., Vereecke N., Theuns S., Oh D.-Y., Vanderheijden N., Trus I., Sauer J., Vyt P., Bonckaert C., Lalonde C., Provost C., Gagnon C.A., Nauwynck H.J.
Comparison of primary virus isolation in pulmonary alveolar macrophages and four different continuous cell lines for type 1 and type 2 porcine reproductive and respiratory syndrome virus.
Vaccines (Basel) 9:594.1-594.13(2021)

PubMed=34737324; DOI=10.1038/s41598-021-00779-5
Lung O., Candlish R.C., Nebroski M., Kruckiewicz P., Buchanan C., Moniwa M.
High-throughput sequencing for species authentication and contamination detection of 63 cell lines.
Sci. Rep. 11:21657-21657(2021)

Cell line collections (Providers) CCLV; CCLV-RIE 0277
CLS; 305006
KCB; KCB 200801YJ
Cell line databases/resources CLO; CLO_0007536
CLDB; cl5226
Anatomy/cell type resources BTO; BTO:0006549
Encyclopedic resources Wikidata; Q54904021
Gene expression databases GEO; GSM1263300
GEO; GSM1263301
GEO; GSM1263302
GEO; GSM1263303
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number23