Cellosaurus cell line Vero-B4 (CVCL

Cellosaurus Vero-B4 (CVCL_1912)

Cross-references
Cell line name	Vero-B4
Synonyms	VERO-B4; Vero B4; VeroB4
Accession	CVCL_1912
Resource Identification Initiative	To cite this cell line use: Vero-B4 (RRID:CVCL_1912)
Comments	Group: Non-human primate cell line. Group: Vaccine production cell line. Virology: Susceptible to infection by Middle East respiratory syndrome-related coronavirus (MERS-CoV) (PubMed=25531820). Virology: Susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=34339474). Doubling time: ~25 hours (DSMZ=ACC-33). Derived from site: In situ; Kidney, epithelium; UBERON=UBERON_0004819. Cell type: Epithelial cell of kidney; CL=CL_0002518.
Species of origin	Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) (NCBI Taxonomy: 60711)
Hierarchy	Parent: CVCL_0059 (Vero)
Sex of cell	Female
Age at sampling	Adult
Category	Spontaneously immortalized cell line
Publications	PubMed=25531820; DOI=10.3201/eid2101.141342 Meyer B., Garcia-Bocanegra I., Wernery U., Wernery R., Sieberg A., Muller M.A., Drexler J.F., Drosten C., Eckerle I. Serologic assessment of possibility for MERS-CoV infection in equids. Emerg. Infect. Dis. 21:181-182(2015) PubMed=34339474; DOI=10.1371/journal.pone.0255622 Pommerenke C., Rand U., Uphoff C.C., Nagel S., Zaborski M., Hauer V., Kaufmann M., Meyer C., Denkmann S.A., Riese P., Eschke K., Kim Y., Safranko Z.M., Kurolt I.-C., Markotic A., Cicin-Sain L., Steenpass L. Identification of cell lines CL-14, CL-40 and CAL-51 as suitable models for SARS-CoV-2 infection studies. PLoS ONE 16:E0255622-E0255622(2021)
Cell line collections (Providers)	CCLV; CCLV-RIE 0929 CCLV; CCLV-RIE 1146 DSMZ; ACC-33
Cell line databases/resources	CLO; CLO_0009528 CLDB; cl4659 DSMZCellDive; ACC-33
Encyclopedic resources	Wikidata; Q54993054
Entry history
Entry creation	04-Apr-2012
Last entry update	05-Oct-2023
Version number	20