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Cellosaurus Caco-2 (CVCL_0025)

[Text version]
Cell line name Caco-2
Synonyms CaCo-2; CACO-2; Caco 2; CACO 2; CACO2; CaCo2; CaCO2; Caco2; Caco-2/ATCC; Caco-II
Accession CVCL_0025
Resource Identification Initiative To cite this cell line use: Caco-2 (RRID:CVCL_0025)
Comments Part of: AstraZeneca Colorectal cell line (AZCL) panel.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: ENCODE project common cell types; tier 3.
Part of: Human Protein Atlas, Cell Atlas panel.
Part of: MD Anderson Cell Lines Project.
Population: Caucasian.
Virology: Highly susceptible to infection by SARS coronavirus (SARS-CoV) (PubMed=15316659; PubMed=15731278).
Virology: Susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=33389257; PubMed=34339474).
Doubling time: 51.41 hours (PubMed=25944804); 3-4 days (ATCC=HTB-37); ~60-70 hours (CLS=300137); ~80 hours (DSMZ=ACC-169); ~32 hours (PBCF).
Microsatellite instability: Stable (MSS) (PubMed=24042735; PubMed=24755471; PubMed=25926053; PubMed=28683746).
Omics: Genomics; ChIP-seq; CTCF.
Omics: Genomics; ChIP-seq; H3K27me3.
Omics: Genomics; ChIP-seq; H3K36me3.
Omics: Genomics; ChIP-seq; H3K4me3.
Omics: Genomics; Whole exome sequencing.
Omics: Glycomics; N-glycan profiling.
Omics: Proteomics.
Omics: Proteomics; Expression; Large antibody panel staining analysis.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; PTM; Phosphorylation.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; miRNA profiling; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Transcriptomics; Serial analysis of gene expression (SAGE).
Omics: Variations; SNP array analysis.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
HLA typing Source: PubMed=25960936
Class I
HLA-AA*02:01,02:01
HLA-BB*15:05,56/39
HLA-CC*04:01,04:01

Source: PubMed=26589293
Class I
HLA-AA*02:01,02:01
HLA-BB*15:01,15:01
HLA-CC*04:01,04:01

Source: CLS=300137
Class I
HLA-AA*02:01:01
HLA-BB*15:01:01
HLA-CC*04:01:01
Class II
HLA-DPDPB1*04:01:01
HLA-DQDQA1*03:01:01
DQB1*03:02:01
HLA-DRDRB1*04:04:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African3.33
Native American0
East Asian, North4.59
East Asian, South0
South Asian0
European, North47.35
European, South44.73
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_B0YL (Abcam Caco-2 ACE2 KO)CVCL_C0BL (Abcam Caco-2 BMP2 KO)CVCL_C0BM (Abcam Caco-2 TMPRSS2 KO)
CVCL_1096 (C2BBe1)CVCL_Z582 (C2BBe2)CVCL_YP11 (Caco-2 Cu Pro-R)
CVCL_YP12 (Caco-2 CuSO4-R)CVCL_C0R8 (Caco-2 DUSP6 KO)CVCL_C8A0 (Caco-2 EJ6)
CVCL_D0R6 (Caco-2 UNC45A KO)CVCL_C9AR (Caco-2-ACE2)CVCL_C8Y3 (Caco-2-Luc)
CVCL_HA82 (Caco-2-RCAr clone 2)CVCL_B6E1 (Caco-2-SF)CVCL_0232 (Caco-2/15)
CVCL_Z578 (Caco-2/3)CVCL_Z579 (Caco-2/PD-10)CVCL_Z580 (Caco-2/PD-7)
CVCL_Z581 (Caco-2/PF-11)CVCL_0233 (Caco-2/TC-7)CVCL_E7J1 (Caco-2(Cas9))
CVCL_C8JI (Caco-2H)CVCL_C8JJ (Caco-2MT)CVCL_C8JK (Caco-2T)
CVCL_D6B0 (HyCyte Caco-2 KO-hAPOA1)CVCL_E3H0 (HyCyte Caco-2-Luc)CVCL_D8FC (Ubigene Caco-2 PPIF KO)
CVCL_D8FD (Ubigene Caco-2 SLC39A8 KO)CVCL_D8FE (Ubigene Caco-2 TAF15 KO)CVCL_D8FF (Ubigene Caco-2 TRPV1 KO)
Sex of cell Male
Age at sampling 72Y
Category Cancer cell line
STR profile Source(s): AddexBio=C0009009/29; ATCC=HTB-37; CCRID; CLS=300137; DSMZ=ACC-169; ECACC=09042001; ECACC=86010202; PubMed=11416159; PubMed=25877200; PubMed=25926053; RCB=RCB0988

Markers:
AmelogeninX
CSF1PO11
D1S165615,16
D2S133817,25
D3S135814,17
D5S81812,13
D7S82011,12 (ATCC=HTB-37; CCRID; CLS=300137; DSMZ=ACC-169; ECACC=09042001; ECACC=86010202; PubMed=25877200; PubMed=25926053; RCB=RCB0988)
12 (AddexBio=C0009009/29)
D8S117912 (DSMZ=ACC-169; PubMed=11416159)
12,14 (ATCC=HTB-37; CCRID; CLS=300137; PubMed=25877200)
D10S124813,15
D12S39117,23
D13S31711,13,14
D16S53912,13
D18S5112
D19S43315
D21S1130 (DSMZ=ACC-169; PubMed=11416159; PubMed=25877200)
30,32 (ATCC=HTB-37; CCRID; CLS=300137; PubMed=25926053)
D22S104515,16
FGA19
Penta D9 (DSMZ=ACC-169)
9,11 (ATCC=HTB-37; PubMed=25877200)
Penta E7
SE3321
TH016
TPOX9,11
vWA16,18

Run an STR similarity search on this cell line
Web pages Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/growth-rate-of-atcc-htb-37
Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/morphology-of-atcc-htb-37
Info; ECACC; -; https://www.culturecollections.org.uk/products/cell-cultures/ecacc-cell-line-profiles/caco-2/
Info; HPA; -; https://www.proteinatlas.org/learn/cellines
Info; MCLP; -; https://tcpaportal.org/mclp/
Info; Synapse; PS-ON; https://www.synapse.org/#!Synapse:syn31544480
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/c/cell-lines-detail-37.html
Info; Wikipedia; -; https://en.wikipedia.org/wiki/Caco-2
Publications

PubMed=327080; DOI=10.1093/jnci/59.1.221
Jorgen Fogh, Jens M. Fogh, Thomas Orfeo;
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Jorgen Fogh, William C. Wright, James D. Loveless;
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=6935474; DOI=10.1093/jnci/66.2.239
William C. Wright, Walter P. Daniels, Jorgen Fogh;
Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis.
J. Natl. Cancer Inst. 66:239-247(1981)

PubMed=7459858
Monique Rousset, Alain Zweibaum, Jorgen Fogh;
Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.
Cancer Res. 41:1165-1170(1981)

PubMed=3518877; DOI=10.3109/07357908609038260
Jorgen Fogh;
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=3349466
Isabelle Chantret, Alain Barbat, Elisabeth Dussaulx, Michael G. Brattain, Alain Zweibaum;
Epithelial polarity, villin expression, and enterocytic differentiation of cultured human colon carcinoma cells: a survey of twenty cell lines.
Cancer Res. 48:1936-1942(1988)

PubMed=2914637; DOI=10.1016/0016-5085(89)90897-4
Ismael J. Hidalgo, Thomas J. Raub, Ronald T. Borchardt;
Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability.
Gastroenterology 96:736-749(1989)

PubMed=7764660; DOI=10.1007/BF00749813
Kei Hashimoto, Makoto Shimizu;
Epithelial properties of human intestinal Caco-2 cells cultured in a serum-free medium.
Cytotechnology 13:175-184(1993)

PubMed=8253353; DOI=10.1016/0016-5085(93)91076-t
Eric Chastre, Sylvie Empereur, Yolande Di Gioia, Nour-Eddine El Mahdani, Marc M. Mareel, Kris L. Vleminckx, Frans M. Van Roy, Valerie Bex, Shahin Emami, Demetrios A. Spandidos, Christian Gespach;
Neoplastic progression of human and rat intestinal cell lines after transfer of the ras and polyoma middle T oncogenes.
Gastroenterology 105:1776-1789(1993)

PubMed=8508948; DOI=10.1111/j.1432-0436.1993.tb00645.x
Adriaan P. de Bruine, Jan E. de Vries, Winand N.M. Dinjens, Peter T.M. Moerkerk, Edith P.M. van der Linden, Margriet M.J. Pijls, Joop ten Kate, Fred Theodoor Bosman;
Human Caco-2 cells transfected with c-Ha-Ras as a model for endocrine differentiation in the large intestine.
Differentiation 53:51-60(1993)

PubMed=9294210; DOI=10.1073/pnas.94.19.10330; PMCID=PMC23362
Mohammad Ilyas, Ian Philip Mark Tomlinson, Andrew J. Rowan, Massimo Pignatelli, Walter Fred Bodmer;
Beta-catenin mutations in cell lines established from human colorectal cancers.
Proc. Natl. Acad. Sci. U.S.A. 94:10330-10334(1997)

PubMed=10092214; DOI=10.1002/(SICI)1097-4652(199812)177:4<618::AID-JCP12>3.0.CO;2-R
Peguy Levy, Helene Robin, Michel Kornprobst, Jacqueline Capeau, Gisele Cherqui;
Enterocytic differentiation of the human Caco-2 cell line correlates with alterations in integrin signaling.
J. Cell. Physiol. 177:618-627(1998)

PubMed=10612807; DOI=10.1002/(SICI)1098-2264(200002)27:2<183::AID-GCC10>3.0.CO;2-P; PMCID=PMC4721570
B. Michael Ghadimi, Dan L. Sackett, Michael J. Difilippantonio, Evelin Schrock, Thomas Neumann, Annukka Jauho, Gert Auer, Thomas Ried;
Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations.
Genes Chromosomes Cancer 27:183-190(2000)

PubMed=10737795; DOI=10.1073/pnas.97.7.3352; PMCID=PMC16243
Andrew J. Rowan, Hanan Lamlum, Mohammad Ilyas, James M.D. Wheeler, Jannes Straub, Angeliki Papadopoulou, David C. Bicknell, Walter Fred Bodmer, Ian Philip Mark Tomlinson;
APC mutations in sporadic colorectal tumors: a mutational 'hotspot' and interdependence of the 'two hits'.
Proc. Natl. Acad. Sci. U.S.A. 97:3352-3357(2000)

PubMed=11414198; DOI=10.1007/s004320000207
Harald Lahm, Sabine Andre, Andreas Hoeflich, Jurgen R. Fischer, Bernard Sordat, Herbert Kaltner, Eckhard Wolf, Hans-Joachim Gabius;
Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.
J. Cancer Res. Clin. Oncol. 127:375-386(2001)

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
John R.W. Masters, Jim A. Thomson, Bernadette Daly-Burns, Yvonne A. Reid, Wilhelm Gerhard Dirks, Phil Packer, Lorraine H. Toji, Tadao Ohno, Hideyuki Tanabe, Colin Francis Arlett, Lloyd R. Kelland ...Show all 16 authors... , Maureen Harrison, Arvind K. Virmani, Timothy H. Ward, Karen L. Ayres, Paul G. Debenham; Show fewer authors
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

PubMed=11668190; DOI=10.1177/002215540104901105
Hilmar Quentmeier, Mary Osborn, Julia Reinhardt, Margarete Zaborski, Hans Gunther Drexler;
Immunocytochemical analysis of cell lines derived from solid tumors.
J. Histochem. Cytochem. 49:1369-1378(2001)

PubMed=12584437; DOI=10.1159/000068544
Ralph Melcher, Sigrid Koehler, Claus Steinlein, Michael Schmid, Clemens R. Mueller, Hardi Luehrs, Thomas Menzel, Wolfgang Scheppach, Hubert Moerk, Michael Scheurlen, Josef Koehrle, Oliver Al-Taie;
Spectral karyotype analysis of colon cancer cell lines of the tumor suppressor and mutator pathway.
Cytogenet. Genome Res. 98:22-28(2002)

PubMed=14599474; DOI=10.1016/S0887-2333(03)00095-X
Giulia Ranaldi, Rosa Consalvo, Yula Sambuy, Maria Laura Scarino;
Permeability characteristics of parental and clonal human intestinal Caco-2 cell lines differentiated in serum-supplemented and serum-free media.
Toxicol. In Vitro 17:761-767(2003)

PubMed=15316659; DOI=10.1007/s00018-004-4222-9; PMCID=PMC7079841
Jindrich Cinatl Jr., Gerold Hoever, Birgit Morgenstern, Wolfgang Preiser, Jens-Uwe Vogel, Wolf-Karsten Hofmann, Gerhard Bauer, Martin Michaelis, Holger F. Rabenau, Hans-Wilhelm Doerr;
Infection of cultured intestinal epithelial cells with severe acute respiratory syndrome coronavirus.
Cell. Mol. Life Sci. 61:2100-2112(2004)

PubMed=15731278; DOI=10.1128/JVI.79.6.3846-3850.2005; PMCID=PMC1075706
Eric C. Mossel, Cheng Huang, Krishna Narayanan, Shinji Makino, Robert B. Tesh, Clarence James Peters;
Exogenous ACE2 expression allows refractory cell lines to support severe acute respiratory syndrome coronavirus replication.
J. Virol. 79:3846-3850(2005)

PubMed=15868485; DOI=10.1007/s10565-005-0085-6
Yula Sambuy, Isabella De Angelis, Giulia Ranaldi, Maria Laura Scarino, Annalaura Stammati, Flavia Zucco;
The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics.
Cell Biol. Toxicol. 21:1-26(2005)

PubMed=16418264; DOI=10.1073/pnas.0510146103; PMCID=PMC1327731
Ying Liu, Walter Fred Bodmer;
Analysis of p53 mutations and their expression in 56 colorectal cancer cell lines.
Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006)

PubMed=16854228; DOI=10.1186/1476-4598-5-29; PMCID=PMC1550420
Eva Maria Bandres Elizalde, Elena Cubedo, Xabier Agirre, Raquel Malumbres, Ruth Zarate, Natalia Ramirez, Ana Abajo, Alfons Navarro, Isabel Moreno, Mariano Monzo, Jesus Garcia-Foncillas;
Identification by real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues.
Mol. Cancer 5:29.1-29.10(2006)

PubMed=16957166; DOI=10.1369/jhc.6A7001.2006; PMCID=PMC3958123
Ann-Catrin Andersson, Sara Stromberg, Helena Backvall, Caroline Kampf, Mathias Uhlen, Kenneth Wester, Fredrik Ponten;
Analysis of protein expression in cell microarrays: a tool for antibody-based proteomics.
J. Histochem. Cytochem. 54:1413-1423(2006)

PubMed=18258742; DOI=10.1073/pnas.0712176105; PMCID=PMC2268141
Muhammad Emaduddin, David C. Bicknell, Walter Fred Bodmer, Stephan M. Feller;
Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells.
Proc. Natl. Acad. Sci. U.S.A. 105:2358-2362(2008)

PubMed=20570890; DOI=10.1158/0008-5472.CAN-10-0192; PMCID=PMC2943514
Manickam Janakiraman, Efsevia Vakiani, Zhao-Shi Zeng, Christine A. Pratilas, Barry Stephen Taylor, Dhananjay Chitale, Ensar Halilovic, Manda Wilson, Kety Huberman, Julio Cezar Marques Ricarte Filho, Yogindra Persaud ...Show all 21 authors... , Douglas A. Levine, James Alexander Fagin, Suresh C. Jhanwar, John M. Mariadason, Alex Lash, Marc Ladanyi, Leonard B. Saltz, Adriana Heguy, Philip B. Paty, David B. Solit; Show fewer authors
Genomic and biological characterization of exon 4 KRAS mutations in human cancer.
Cancer Res. 70:5901-5911(2010)

PubMed=20606684; DOI=10.1038/sj.bjc.6605780; PMCID=PMC2920028
Karin Bracht, Angela M. Nicholls, Ying Liu, Walter Fred Bodmer;
5-fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.
Br. J. Cancer 103:340-346(2010)

PubMed=20831567; DOI=10.1111/j.1582-4934.2010.01170.x; PMCID=PMC3918049
Yan-Lei Ma, Peng Zhang, Feng Wang, Mary Pat Moyer, Jian-Jun Yang, Zhi-Hua Liu, Jiang-Yun Peng, Hong-Qi Chen, Yu-Kun Zhou, Wei-Jie Liu, Huan-Long Qin;
Human embryonic stem cells and metastatic colorectal cancer cells shared the common endogenous human microRNA-26b.
J. Cell. Mol. Med. 15:1941-1954(2011)

PubMed=21607810; DOI=10.1208/s12248-011-9283-8; PMCID=PMC3160153
Ronald T. Borchardt;
Hidalgo, I.J., Raub, T.J., and Borchardt, R.T.: Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability, Gastroenterology, 96, 736-749, 1989 -- the backstory.
AAPS J. 13:323-327(2011)

PubMed=23272949; DOI=10.1186/1755-8794-5-66; PMCID=PMC3543849
Andreas Schlicker, Garry Beran, Christine M. Chresta, Gael McWalter, Alison Pritchard, Susie Weston, Sarah Runswick, Sara Davenport, Kerry Heathcote, Denis Alferez Castro, George Orphanides ...Show all 13 authors... , Tim French, Lodewyk F.A. Wessels; Show fewer authors
Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines.
BMC Med. Genomics 5:66.1-66.15(2012)

PubMed=23932154; DOI=10.1016/j.radonc.2013.06.032
Junius Salendo, Melanie Spitzner, Frank Kramer, Xin Zhang, Peter Jo, Hendrik A. Wolff, Julia Kitz, Silke Kaulfuss, Tim Beissbarth, Matthias Dobbelstein, Michael Ghadimi ...Show all 13 authors... , Marian Grade, Jochen Gaedcke; Show fewer authors
Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g.
Radiother. Oncol. 108:451-457(2013)

PubMed=24042735; DOI=10.1038/oncsis.2013.35; PMCID=PMC3816225
Deeqa Ahmed, Peter W. Eide, Ina A. Eilertsen, Stine A. Danielsen, Mette Eknaes, Merete Hektoen, Guro Elisabeth Lind, Ragnhild Adelheid Lothe;
Epigenetic and genetic features of 24 colon cancer cell lines.
Oncogenesis 2:e71.1-e71.8(2013)

PubMed=24755471; DOI=10.1158/0008-5472.CAN-14-0013
Dmitri Mouradov, Clare Sloggett, Robert N. Jorissen, Christopher G. Love, Shan Li, Antony Wilks Burgess, Diego Arango, Robert L. Strausberg, Daniel Buchanan, Samuel Wormald, Liam O'Connor ...Show all 17 authors... , Jennifer L. Wilding, David C. Bicknell, Ian Philip Mark Tomlinson, Walter Fred Bodmer, John M. Mariadason, Oliver M. Sieber; Show fewer authors
Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.
Cancer Res. 74:3238-3247(2014)

PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981
Sebastian Boegel, Martin Lower, Thomas Bukur, Ugur Sahin, John C. Castle;
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25841592; DOI=10.1016/j.jprot.2015.03.019
Sander R. Piersma, Jaco C. Knol, Inge de Reus, Mariette Labots, Bharath K. Sampadi, Thang V. Pham, Yasushi Ishihama, Henk M.W. Verheul, Connie R. Jimenez;
Feasibility of label-free phosphoproteomics and application to base-line signaling of colorectal cancer cell lines.
J. Proteomics 127:247-258(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=25926053; DOI=10.1038/ncomms8002
Enzo Medico, Mariangela Russo, Gabriele Picco, Carlotta Cancelliere, Emanuele Valtorta, Giorgio Corti, Michela Buscarino, Claudio Isella, Simona Lamba, Barbara Martinoglio, Silvio Veronese ...Show all 19 authors... , Salvatore Siena, Andrea Sartore-Bianchi, Marco Beccuti, Marcella Mottolese, Michael Linnebacher, Francesca Cordero, Federica Di Nicolantonio, Alberto Bardelli; Show fewer authors
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

PubMed=25944804; DOI=10.1158/1078-0432.CCR-14-2457
Sarah Bazzocco, Higinio Dopeso, Fernando Carton-Garcia, Irati Macaya, Elena Andretta, Fiona Chionh, Paulo Rodrigues, Miriam Garrido, Hafid Alazzouzi, Rocio Nieto, Alex Sanchez ...Show all 15 authors... , Simo Schwartz Jr., Josipa Bilic, John M. Mariadason, Diego Arango; Show fewer authors
Highly expressed genes in rapidly proliferating tumor cells as new targets for colorectal cancer treatment.
Clin. Cancer Res. 21:3695-3704(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=29787057; DOI=10.1007/978-3-319-16104-4_10
Tor Lea;
Caco-2 cell line.
(In book chapter) The impact of food bioactives on health. In vitro and ex vivo models; Verhoeckx, Kitty & Cotter, Paul David & Lopez-Exposito, Ivan & Kleiveland, Charlotte Ramstad & Lea, Tor & Mackie, Alan Robert & Requena, Teresa & Swiatecka, Dominika & Wichers, Harry J. (eds.); pp.103-111; Springer; Cham; Switzerland (2015)

PubMed=26537799; DOI=10.1074/mcp.M115.051235; PMCID=PMC4762531
Stephanie Holst, Anna J.M. Deuss, Gabi W. van Pelt, Sandra Johanna van Vliet, Juan J. Garcia-Vallejo, Carolien A.M. Koeleman, Andre M. Deelder, Wilma E. Mesker, Rob A.E.M. Tollenaar, Yoann Rombouts, Manfred Wuhrer;
N-glycosylation profiling of colorectal cancer cell lines reveals association of fucosylation with differentiation and caudal type homebox 1 (CDX1)/villin mRNA expression.
Mol. Cell. Proteomics 15:124-140(2016)

PubMed=26869432; DOI=10.1016/j.xphs.2015.10.030
Magnus Olander, Jacek R. Wisniewski, Par Matsson, Patrik Lundquist, Per Artursson;
The proteome of filter-grown Caco-2 cells with a focus on proteins involved in drug disposition.
J. Pharm. Sci. 105:817-827(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=28683746; DOI=10.1186/s12943-017-0691-y; PMCID=PMC5498998
Kaja Christine Graue Berg, Peter W. Eide, Ina A. Eilertsen, Bjarne Johannessen, Jarle Bruun, Stine A. Danielsen, Merete Bjornslett, Leonardo Andres Meza-Zepeda, Mette Eknaes, Guro Elisabeth Lind, Ola Myklebost ...Show all 14 authors... , Rolf Inge Skotheim, Anita Sveen, Ragnhild Adelheid Lothe; Show fewer authors
Multi-omics of 34 colorectal cancer cell lines -- a resource for biomedical studies.
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Cross-references
Cell line collections (Providers) Abcam; ab275464 - Discontinued
AddexBio; C0009009/29
ATCC; HTB-37
BCRJ; 0059
CCTCC; GDC0153
CLS; 300137
DSMZ; ACC-169
ECACC; 09042001
ECACC; 86010202
IBRC; C10094
ICLC; HTL97023
IZSLER; BS TCL 87
KCB; KCB 200710YJ
KCLB; 30037.1
NCBI_Iran; C139
RCB; RCB0988
Ubigene; YC-D003
Cell line databases/resources CLO; CLO_0002172
CLO; CLO_0050627
MCCL; MCC:0000120
CLDB; cl614
CLDB; cl615
CLDB; cl616
CLDB; cl617
CLDB; cl618
CLDB; cl619
CLDB; cl621
CLDB; cl5174
cancercelllines; CVCL_0025
CCRID; 1101HUM-PUMC000100
CCRID; 1102HUM-NIFDC00087
CCRID; 3101HUMSCSP5027
CCRID; 3101HUMTCHu146
CCRID; 4201HUM-CCTCC00153
CCRID; 5301HUM-KCB07010YJ
Cell_Model_Passport; SIDM00891
ColonAtlas; CACO2
DepMap; ACH-000003
DSMZCellDive; ACC-169
FCS-free; 192-2-378-1-3-3
LINCS_LDP; LCL-1170
Lonza; 36
TOKU-E; 762
Anatomy/cell type resources BTO; BTO_0000195
Biological sample resources BioSample; SAMN03473140
BioSample; SAMN05292461
BioSample; SAMN10989600
ENCODE; ENCBS311PHE
ENCODE; ENCBS390JMI
ENCODE; ENCBS391ENC
ENCODE; ENCBS530YXL
ENCODE; ENCBS700RKG
ENCODE; ENCBS890JZY
Chemistry resources ChEMBL-Cells; CHEMBL3307519
ChEMBL-Targets; CHEMBL614058
PharmacoDB; Caco2_161_2019
PubChem_Cell_line; CVCL_0025
Encyclopedic resources Wikidata; Q5016050
Experimental variables resources EFO; EFO_0001099
Gene expression databases ArrayExpress; E-MTAB-2706
FANTOM5_SSTAR; 10513-107D9
GEO; GSM206450
GEO; GSM274711
GEO; GSM274712
GEO; GSM274725
GEO; GSM383861
GEO; GSM472900
GEO; GSM472933
GEO; GSM513908
GEO; GSM514182
GEO; GSM741244
GEO; GSM749689
GEO; GSM749691
GEO; GSM749748
GEO; GSM784006
GEO; GSM843481
GEO; GSM843482
GEO; GSM845394
GEO; GSM945162
GEO; GSM945203
GEO; GSM945206
GEO; GSM945236
GEO; GSM1006210
GEO; GSM1006211
GEO; GSM1006212
GEO; GSM1346866
GEO; GSM1374426
GEO; GSM1448160
GEO; GSM2549989
GEO; GSM7701359
GEO; GSM7701360
Medical resources MeSH; D018938
Metabolomic databases MetaboLights; MTBLS227
MetaboLights; MTBLS328
Polymorphism and mutation databases Cosmic; 720340
Cosmic; 873696
Cosmic; 875297
Cosmic; 876709
Cosmic; 887244
Cosmic; 889531
Cosmic; 948127
Cosmic; 948829
Cosmic; 983736
Cosmic; 995392
Cosmic; 1043805
Cosmic; 1122320
Cosmic; 1132564
Cosmic; 1132694
Cosmic; 1184081
Cosmic; 1187299
Cosmic; 1310931
Cosmic; 1466811
Cosmic; 1479620
Cosmic; 1524334
Cosmic; 1552180
Cosmic; 1676742
Cosmic; 1708415
Cosmic; 1803940
Cosmic; 1933015
Cosmic; 2036652
Cosmic; 2145574
Cosmic; 2156940
Cosmic; 2301543
Cosmic; 2301964
Cosmic; 2667879
Cosmic; 2800568
IARC_TP53; 21749
Progenetix; CVCL_0025
Proteomic databases PRIDE; PXD001550
PRIDE; PXD005354
PRIDE; PXD005355
PRIDE; PXD018357
PRIDE; PXD019645
PRIDE; PXD023760
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001002554
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number52