ID Caco-2 AC CVCL_0025 SY CaCo-2; CACO-2; Caco 2; CACO 2; CACO2; CaCo2; CaCO2; Caco2; Caco-2/ATCC; Caco-II DR BTO; BTO_0000195 DR CLO; CLO_0002172 DR CLO; CLO_0050627 DR EFO; EFO_0001099 DR MCCL; MCC:0000120 DR CLDB; cl614 DR CLDB; cl615 DR CLDB; cl616 DR CLDB; cl617 DR CLDB; cl618 DR CLDB; cl619 DR CLDB; cl621 DR CLDB; cl5174 DR Abcam; ab275464 DR AddexBio; C0009009/29 DR ArrayExpress; E-MTAB-2706 DR ATCC; HTB-37 DR BCRJ; 0059 DR BioSample; SAMN03473140 DR BioSample; SAMN05292461 DR BioSample; SAMN10989600 DR cancercelllines; CVCL_0025 DR CCRID; 1101HUM-PUMC000100 DR CCRID; 1102HUM-NIFDC00087 DR CCRID; 3101HUMSCSP5027 DR CCRID; 3101HUMTCHu146 DR CCRID; 4201HUM-CCTCC00153 DR CCRID; 5301HUM-KCB07010YJ DR CCTCC; GDC0153 DR Cell_Model_Passport; SIDM00891 DR ChEMBL-Cells; CHEMBL3307519 DR ChEMBL-Targets; CHEMBL614058 DR CLS; 300137 DR ColonAtlas; CACO2 DR Cosmic; 720340 DR Cosmic; 873696 DR Cosmic; 875297 DR Cosmic; 876709 DR Cosmic; 887244 DR Cosmic; 889531 DR Cosmic; 948127 DR Cosmic; 948829 DR Cosmic; 983736 DR Cosmic; 995392 DR Cosmic; 1043805 DR Cosmic; 1122320 DR Cosmic; 1132564 DR Cosmic; 1132694 DR Cosmic; 1184081 DR Cosmic; 1187299 DR Cosmic; 1310931 DR Cosmic; 1466811 DR Cosmic; 1479620 DR Cosmic; 1524334 DR Cosmic; 1552180 DR Cosmic; 1676742 DR Cosmic; 1708415 DR Cosmic; 1803940 DR Cosmic; 1933015 DR Cosmic; 2036652 DR Cosmic; 2145574 DR Cosmic; 2156940 DR Cosmic; 2301543 DR Cosmic; 2301964 DR Cosmic; 2667879 DR Cosmic; 2800568 DR DepMap; ACH-000003 DR DSMZ; ACC-169 DR DSMZCellDive; ACC-169 DR ECACC; 09042001 DR ECACC; 86010202 DR EGA; EGAS00001000610 DR EGA; EGAS00001002554 DR ENCODE; ENCBS311PHE DR ENCODE; ENCBS390JMI DR ENCODE; ENCBS391ENC DR ENCODE; ENCBS530YXL DR ENCODE; ENCBS700RKG DR ENCODE; ENCBS890JZY DR FANTOM5_SSTAR; 10513-107D9 DR FCS-free; 192-2-378-1-3-3 DR GEO; GSM206450 DR GEO; GSM274711 DR GEO; GSM274712 DR GEO; GSM274725 DR GEO; GSM383861 DR GEO; GSM472900 DR GEO; GSM472933 DR GEO; GSM513908 DR GEO; GSM514182 DR GEO; GSM741244 DR GEO; GSM749689 DR GEO; GSM749691 DR GEO; GSM749748 DR GEO; GSM784006 DR GEO; GSM843481 DR GEO; GSM843482 DR GEO; GSM845394 DR GEO; GSM945162 DR GEO; GSM945203 DR GEO; GSM945206 DR GEO; GSM945236 DR GEO; GSM1006210 DR GEO; GSM1006211 DR GEO; GSM1006212 DR GEO; GSM1346866 DR GEO; GSM1374426 DR GEO; GSM1448160 DR GEO; GSM2549989 DR GEO; GSM7701359 DR GEO; GSM7701360 DR IARC_TP53; 21749 DR IBRC; C10094 DR ICLC; HTL97023 DR IZSLER; BS TCL 87 DR KCB; KCB 200710YJ DR KCLB; 30037.1 DR LINCS_LDP; LCL-1170 DR Lonza; 36 DR MeSH; D018938 DR MetaboLights; MTBLS227 DR MetaboLights; MTBLS328 DR NCBI_Iran; C139 DR PharmacoDB; Caco2_161_2019 DR PRIDE; PXD001550 DR PRIDE; PXD005354 DR PRIDE; PXD005355 DR PRIDE; PXD018357 DR PRIDE; PXD019645 DR PRIDE; PXD023760 DR Progenetix; CVCL_0025 DR PubChem_Cell_line; CVCL_0025 DR RCB; RCB0988 DR TOKU-E; 762 DR Ubigene; YC-D003 DR Wikidata; Q5016050 RX PubMed=327080; RX PubMed=833871; RX PubMed=2914637; RX PubMed=3349466; RX PubMed=3518877; RX PubMed=6935474; RX PubMed=7459858; RX PubMed=7764660; RX PubMed=8253353; RX PubMed=8508948; RX PubMed=9294210; RX PubMed=10092214; RX PubMed=10612807; RX PubMed=10737795; RX PubMed=11414198; RX PubMed=11416159; RX PubMed=11668190; RX PubMed=12584437; RX PubMed=14599474; RX PubMed=15316659; RX PubMed=15731278; RX PubMed=15868485; RX PubMed=16418264; RX PubMed=16854228; RX PubMed=16957166; RX PubMed=18258742; RX PubMed=20570890; RX PubMed=20606684; RX PubMed=20831567; RX PubMed=21607810; RX PubMed=23272949; RX PubMed=23932154; RX PubMed=24042735; RX PubMed=24755471; RX PubMed=25485619; RX PubMed=25841592; RX PubMed=25877200; RX PubMed=25926053; RX PubMed=25944804; RX PubMed=25960936; RX PubMed=26537799; RX PubMed=26589293; RX PubMed=26869432; RX PubMed=28196595; RX PubMed=28683746; RX PubMed=29101300; RX PubMed=29787057; RX PubMed=30894373; RX PubMed=31068700; RX PubMed=31981602; RX PubMed=33389257; RX PubMed=34339474; WW Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/growth-rate-of-atcc-htb-37 WW Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/morphology-of-atcc-htb-37 WW Info; ECACC; -; https://www.culturecollections.org.uk/products/cell-cultures/ecacc-cell-line-profiles/caco-2/ WW Info; HPA; -; https://www.proteinatlas.org/learn/cellines WW Info; MCLP; -; https://tcpaportal.org/mclp/ WW Info; Synapse; PS-ON; https://www.synapse.org/#!Synapse:syn31544480 WW Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/c/cell-lines-detail-37.html WW Info; Wikipedia; -; https://en.wikipedia.org/wiki/Caco-2 CC Part of: AstraZeneca Colorectal cell line (AZCL) panel. CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: ENCODE project common cell types; tier 3. CC Part of: Human Protein Atlas, Cell Atlas panel. CC Part of: MD Anderson Cell Lines Project. CC Population: Caucasian. CC Virology: Highly susceptible to infection by SARS coronavirus (SARS-CoV) (PubMed=15316659; PubMed=15731278). CC Virology: Susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=33389257; PubMed=34339474). CC Doubling time: 51.41 hours (PubMed=25944804); 3-4 days (ATCC=HTB-37); ~60-70 hours (CLS=300137); ~80 hours (DSMZ=ACC-169); ~32 hours (PBCF). CC HLA typing: A*02:01,02:01; B*15:05,56/39; C*04:01,04:01 (PubMed=25960936). CC HLA typing: A*02:01,02:01; B*15:01,15:01; C*04:01,04:01 (PubMed=26589293). CC HLA typing: A*02:01:01; B*15:01:01; C*04:01:01; DPB1*04:01:01; DQA1*03:01:01; DQB1*03:02:01; DRB1*04:04:01 (CLS=300137). CC Microsatellite instability: Stable (MSS) (PubMed=24042735; PubMed=24755471; PubMed=25926053; PubMed=28683746). CC Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (PubMed=24755471; DepMap=ACH-000003). CC Sequence variation: Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (PubMed=9294210). CC Sequence variation: Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (PubMed=24755471; DepMap=ACH-000003). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (PubMed=16418264; PubMed=24755471; PubMed=28683746; DepMap=ACH-000003). CC Omics: Genomics; ChIP-seq; CTCF. CC Omics: Genomics; ChIP-seq; H3K27me3. CC Omics: Genomics; ChIP-seq; H3K36me3. CC Omics: Genomics; ChIP-seq; H3K4me3. CC Omics: Genomics; Whole exome sequencing. CC Omics: Glycomics; N-glycan profiling. CC Omics: Proteomics. CC Omics: Proteomics; Expression; Large antibody panel staining analysis. CC Omics: Proteomics; Expression; Reverse-phase protein array. CC Omics: Proteomics; PTM; Phosphorylation. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; miRNA profiling; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Transcriptomics; Serial analysis of gene expression (SAGE). CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=3.33%; Native American=0%; East Asian, North=4.59%; East Asian, South=0%; South Asian=0%; European, North=47.35%; European, South=44.73% (PubMed=30894373). CC Discontinued: Abcam; ab275464; true. CC Derived from site: In situ; Colon; UBERON=UBERON_0001155. ST Source(s): AddexBio=C0009009/29; ATCC=HTB-37; CCRID; CLS=300137; DSMZ=ACC-169; ECACC=09042001; ECACC=86010202; PubMed=11416159; PubMed=25877200; PubMed=25926053; RCB=RCB0988 ST Amelogenin: X ST CSF1PO: 11 ST D10S1248: 13,15 ST D12S391: 17,23 ST D13S317: 11,13,14 ST D16S539: 12,13 ST D18S51: 12 ST D19S433: 15 ST D1S1656: 15,16 ST D21S11: 30 (DSMZ=ACC-169; PubMed=11416159; PubMed=25877200) ST D21S11: 30,32 (ATCC=HTB-37; CCRID; CLS=300137; PubMed=25926053) ST D22S1045: 15,16 ST D2S1338: 17,25 ST D3S1358: 14,17 ST D5S818: 12,13 ST D7S820: 11,12 (ATCC=HTB-37; CCRID; CLS=300137; DSMZ=ACC-169; ECACC=09042001; ECACC=86010202; PubMed=25877200; PubMed=25926053; RCB=RCB0988) ST D7S820: 12 (AddexBio=C0009009/29) ST D8S1179: 12 (DSMZ=ACC-169; PubMed=11416159) ST D8S1179: 12,14 (ATCC=HTB-37; CCRID; CLS=300137; PubMed=25877200) ST FGA: 19 ST Penta D: 9 (DSMZ=ACC-169) ST Penta D: 9,11 (ATCC=HTB-37; PubMed=25877200) ST Penta E: 7 ST SE33: 21 ST TH01: 6 ST TPOX: 9,11 ST vWA: 16,18 DI NCIt; C4349; Colon adenocarcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG 72Y CA Cancer cell line DT Created: 04-04-12; Last updated: 14-08-25; Version: 52 CH CVCL_B0YL ! Abcam Caco-2 ACE2 KO CH CVCL_C0BL ! Abcam Caco-2 BMP2 KO CH CVCL_C0BM ! Abcam Caco-2 TMPRSS2 KO CH CVCL_1096 ! C2BBe1 CH CVCL_Z582 ! C2BBe2 CH CVCL_YP11 ! Caco-2 Cu Pro-R CH CVCL_YP12 ! Caco-2 CuSO4-R CH CVCL_C0R8 ! Caco-2 DUSP6 KO CH CVCL_C8A0 ! Caco-2 EJ6 CH CVCL_D0R6 ! Caco-2 UNC45A KO CH CVCL_C9AR ! Caco-2-ACE2 CH CVCL_C8Y3 ! Caco-2-Luc CH CVCL_HA82 ! Caco-2-RCAr clone 2 CH CVCL_B6E1 ! Caco-2-SF CH CVCL_0232 ! Caco-2/15 CH CVCL_Z578 ! Caco-2/3 CH CVCL_Z579 ! Caco-2/PD-10 CH CVCL_Z580 ! Caco-2/PD-7 CH CVCL_Z581 ! Caco-2/PF-11 CH CVCL_0233 ! Caco-2/TC-7 CH CVCL_E7J1 ! Caco-2(Cas9) CH CVCL_C8JI ! Caco-2H CH CVCL_C8JJ ! Caco-2MT CH CVCL_C8JK ! Caco-2T CH CVCL_D6B0 ! HyCyte Caco-2 KO-hAPOA1 CH CVCL_E3H0 ! HyCyte Caco-2-Luc CH CVCL_D8FC ! Ubigene Caco-2 PPIF KO CH CVCL_D8FD ! Ubigene Caco-2 SLC39A8 KO CH CVCL_D8FE ! Ubigene Caco-2 TAF15 KO CH CVCL_D8FF ! Ubigene Caco-2 TRPV1 KO // RX PubMed=16957166; DOI=10.1369/jhc.6A7001.2006; PMCID=PMC3958123; RA Andersson, Ann-Catrin RA Stromberg, Sara RA Backvall, Helena RA Kampf, Caroline RA Uhlen, Mathias RA Wester, Kenneth RA Ponten, Fredrik RT "Analysis of protein expression in cell microarrays: a tool for RT antibody-based proteomics."; RL J. Histochem. Cytochem. 54:1413-1423(2006). // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn, Christiaan RA Durinck, Steffen RA Stawiski, Eric W. RA Haverty, Peter M. RA Jiang, Zhao-Shi RA Liu, Han-Bin RA Degenhardt, Jeremiah RA Mayba, Oleg RA Gnad, Florian RA Liu, Jin-Feng RA Pau, Gregoire RA Reeder, Jens RA Cao, Yi RA Mukhyala, Kiran RA Selvaraj, Suresh K. RA Yu, Ma-Mie RA Zynda, Gregory J. RA Brauer, Matthew J. RA Wu, Thomas D. RA Gentleman, Robert Clifford RA Manning, Gerard RA Yauch, Robert L. RA Bourgon, Richard RA Stokoe, David RA Modrusan, Zora RA Neve, Richard M. RA de Sauvage, Frederic J. RA Settleman, Jeffrey RA Seshagiri, Somasekar RA Zhang, Ze-Min RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. Biotechnol. 33:306-312(2015). // RX PubMed=29101300; DOI=10.15252/msb.20177701; PMCID=PMC5731344; RA Frejno, Martin RA Zenezini Chiozzi, Riccardo RA Wilhelm, Mathias RA Koch, Heiner RA Zheng, Run-Sheng RA Klaeger, Susan RA Ruprecht, Benjamin RA Meng, Chen RA Kramer, Karl RA Jarzab, Anna RA Heinzlmeir, Stephanie RA Johnstone, Elaine RA Domingo, Enric RA Kerr, David James RA Jesinghaus, Moritz RA Slotta-Huspenina, Julia RA Weichert, Wilko RA Knapp, Stefan RA Feller, Stephan M. RA Kuster, Bernhard RT "Pharmacoproteomic characterisation of human colon and rectal RT cancer."; RL Mol. Syst. Biol. 13:951-951(2017). // RX PubMed=26869432; DOI=10.1016/j.xphs.2015.10.030; RA Olander, Magnus RA Wisniewski, Jacek R. RA Matsson, Par RA Lundquist, Patrik RA Artursson, Per RT "The proteome of filter-grown Caco-2 cells with a focus on proteins RT involved in drug disposition."; RL J. Pharm. Sci. 105:817-827(2016). // RX PubMed=29787057; DOI=10.1007/978-3-319-16104-4_10; RA Lea, Tor RT "Caco-2 cell line."; RL (In book chapter) The impact of food bioactives on health. In vitro and ex vivo models; Verhoeckx, Kitty & Cotter, Paul David & Lopez-Exposito, Ivan & Kleiveland, Charlotte Ramstad & Lea, Tor & Mackie, Alan Robert & Requena, Teresa & Swiatecka, Dominika & Wichers, Harry J. (eds.); pp.103-111; Springer; Cham; Switzerland (2015). // RX PubMed=12584437; DOI=10.1159/000068544; RA Melcher, Ralph RA Koehler, Sigrid RA Steinlein, Claus RA Schmid, Michael RA Mueller, Clemens R. RA Luehrs, Hardi RA Menzel, Thomas RA Scheppach, Wolfgang RA Moerk, Hubert RA Scheurlen, Michael RA Koehrle, Josef RA Al-Taie, Oliver RT "Spectral karyotype analysis of colon cancer cell lines of the tumor RT suppressor and mutator pathway."; RL Cytogenet. Genome Res. 98:22-28(2002). // RX PubMed=25841592; DOI=10.1016/j.jprot.2015.03.019; RA Piersma, Sander R. RA Knol, Jaco C. RA de Reus, Inge RA Labots, Mariette RA Sampadi, Bharath K. RA Pham, Thang V. RA Ishihama, Yasushi RA Verheul, Henk M.W. RA Jimenez, Connie R. RT "Feasibility of label-free phosphoproteomics and application to RT base-line signaling of colorectal cancer cell lines."; RL J. Proteomics 127:247-258(2015). // RX PubMed=15868485; DOI=10.1007/s10565-005-0085-6; RA Sambuy, Yula RA De Angelis, Isabella RA Ranaldi, Giulia RA Scarino, Maria Laura RA Stammati, Annalaura RA Zucco, Flavia RT "The Caco-2 cell line as a model of the intestinal barrier: influence RT of cell and culture-related factors on Caco-2 cell functional RT characteristics."; RL Cell Biol. Toxicol. 21:1-26(2005). // RX PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981; RA Boegel, Sebastian RA Lower, Martin RA Bukur, Thomas RA Sahin, Ugur RA Castle, John C. RT "A catalog of HLA type, HLA expression, and neo-epitope candidates in RT human cancer cell lines."; RL OncoImmunology 3:e954893.1-e954893.12(2014). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=28683746; DOI=10.1186/s12943-017-0691-y; PMCID=PMC5498998; RA Berg, Kaja Christine Graue RA Eide, Peter W. RA Eilertsen, Ina A. RA Johannessen, Bjarne RA Bruun, Jarle RA Danielsen, Stine A. RA Bjornslett, Merete RA Meza-Zepeda, Leonardo Andres RA Eknaes, Mette RA Lind, Guro Elisabeth RA Myklebost, Ola RA Skotheim, Rolf Inge RA Sveen, Anita RA Lothe, Ragnhild Adelheid RT "Multi-omics of 34 colorectal cancer cell lines -- a resource for RT biomedical studies."; RL Mol. Cancer 16:116.1-116.16(2017). // RX PubMed=6935474; DOI=10.1093/jnci/66.2.239; RA Wright, William C. RA Daniels, Walter P. RA Fogh, Jorgen RT "Distinction of seventy-one cultured human tumor cell lines by RT polymorphic enzyme analysis."; RL J. Natl. Cancer Inst. 66:239-247(1981). // RX PubMed=327080; DOI=10.1093/jnci/59.1.221; RA Fogh, Jorgen RA Fogh, Jens M. RA Orfeo, Thomas RT "One hundred and twenty-seven cultured human tumor cell lines RT producing tumors in nude mice."; RL J. Natl. Cancer Inst. 59:221-226(1977). // RX PubMed=14599474; DOI=10.1016/S0887-2333(03)00095-X; RA Ranaldi, Giulia RA Consalvo, Rosa RA Sambuy, Yula RA Scarino, Maria Laura RT "Permeability characteristics of parental and clonal human intestinal RT Caco-2 cell lines differentiated in serum-supplemented and serum-free RT media."; RL Toxicol. In Vitro 17:761-767(2003). // RX PubMed=7459858; RA Rousset, Monique RA Zweibaum, Alain RA Fogh, Jorgen RT "Presence of glycogen and growth-related variations in 58 cultured RT human tumor cell lines of various tissue origins."; RL Cancer Res. 41:1165-1170(1981). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=16854228; DOI=10.1186/1476-4598-5-29; PMCID=PMC1550420; RA Bandres Elizalde, Eva Maria RA Cubedo, Elena RA Agirre, Xabier RA Malumbres, Raquel RA Zarate, Ruth RA Ramirez, Natalia RA Abajo, Ana RA Navarro, Alfons RA Moreno, Isabel RA Monzo, Mariano RA Garcia-Foncillas, Jesus RT "Identification by real-time PCR of 13 mature microRNAs differentially RT expressed in colorectal cancer and non-tumoral tissues."; RL Mol. Cancer 5:29.1-29.10(2006). // RX PubMed=20606684; DOI=10.1038/sj.bjc.6605780; PMCID=PMC2920028; RA Bracht, Karin RA Nicholls, Angela M. RA Liu, Ying RA Bodmer, Walter Fred RT "5-fluorouracil response in a large panel of colorectal cancer cell RT lines is associated with mismatch repair deficiency."; RL Br. J. Cancer 103:340-346(2010). // RX PubMed=26537799; DOI=10.1074/mcp.M115.051235; PMCID=PMC4762531; RA Holst, Stephanie RA Deuss, Anna J.M. RA van Pelt, Gabi W. RA van Vliet, Sandra Johanna RA Garcia-Vallejo, Juan J. RA Koeleman, Carolien A.M. RA Deelder, Andre M. RA Mesker, Wilma E. RA Tollenaar, Rob A.E.M. RA Rombouts, Yoann RA Wuhrer, Manfred RT "N-glycosylation profiling of colorectal cancer cell lines reveals RT association of fucosylation with differentiation and caudal type RT homebox 1 (CDX1)/villin mRNA expression."; RL Mol. Cell. Proteomics 15:124-140(2016). // RX PubMed=25944804; DOI=10.1158/1078-0432.CCR-14-2457; RA Bazzocco, Sarah RA Dopeso, Higinio RA Carton-Garcia, Fernando RA Macaya, Irati RA Andretta, Elena RA Chionh, Fiona RA Rodrigues, Paulo RA Garrido, Miriam RA Alazzouzi, Hafid RA Nieto, Rocio RA Sanchez, Alex RA Schwartz, Simo Jr. RA Bilic, Josipa RA Mariadason, John M. RA Arango, Diego RT "Highly expressed genes in rapidly proliferating tumor cells as new RT targets for colorectal cancer treatment."; RL Clin. Cancer Res. 21:3695-3704(2015). // RX PubMed=8253353; DOI=10.1016/0016-5085(93)91076-t; RA Chastre, Eric RA Empereur, Sylvie RA Di Gioia, Yolande RA El Mahdani, Nour-Eddine RA Mareel, Marc M. RA Vleminckx, Kris L. RA Van Roy, Frans M. RA Bex, Valerie RA Emami, Shahin RA Spandidos, Demetrios A. RA Gespach, Christian RT "Neoplastic progression of human and rat intestinal cell lines after RT transfer of the ras and polyoma middle T oncogenes."; RL Gastroenterology 105:1776-1789(1993). // RX PubMed=23932154; DOI=10.1016/j.radonc.2013.06.032; RA Salendo, Junius RA Spitzner, Melanie RA Kramer, Frank RA Zhang, Xin RA Jo, Peter RA Wolff, Hendrik A. RA Kitz, Julia RA Kaulfuss, Silke RA Beissbarth, Tim RA Dobbelstein, Matthias RA Ghadimi, Michael RA Grade, Marian RA Gaedcke, Jochen RT "Identification of a microRNA expression signature for RT chemoradiosensitivity of colorectal cancer cells, involving RT miRNAs-320a, -224, -132 and let7g."; RL Radiother. Oncol. 108:451-457(2013). // RX PubMed=20570890; DOI=10.1158/0008-5472.CAN-10-0192; PMCID=PMC2943514; RA Janakiraman, Manickam RA Vakiani, Efsevia RA Zeng, Zhao-Shi RA Pratilas, Christine A. RA Taylor, Barry Stephen RA Chitale, Dhananjay RA Halilovic, Ensar RA Wilson, Manda RA Huberman, Kety RA Ricarte Filho, Julio Cezar Marques RA Persaud, Yogindra RA Levine, Douglas A. RA Fagin, James Alexander RA Jhanwar, Suresh C. RA Mariadason, John M. RA Lash, Alex RA Ladanyi, Marc RA Saltz, Leonard B. RA Heguy, Adriana RA Paty, Philip B. RA Solit, David B. RT "Genomic and biological characterization of exon 4 KRAS mutations in RT human cancer."; RL Cancer Res. 70:5901-5911(2010). // RX PubMed=15316659; DOI=10.1007/s00018-004-4222-9; PMCID=PMC7079841; RA Cinatl, Jindrich Jr. RA Hoever, Gerold RA Morgenstern, Birgit RA Preiser, Wolfgang RA Vogel, Jens-Uwe RA Hofmann, Wolf-Karsten RA Bauer, Gerhard RA Michaelis, Martin RA Rabenau, Holger F. RA Doerr, Hans-Wilhelm RT "Infection of cultured intestinal epithelial cells with severe acute RT respiratory syndrome coronavirus."; RL Cell. Mol. Life Sci. 61:2100-2112(2004). // RX PubMed=11668190; DOI=10.1177/002215540104901105; RA Quentmeier, Hilmar RA Osborn, Mary RA Reinhardt, Julia RA Zaborski, Margarete RA Drexler, Hans Gunther RT "Immunocytochemical analysis of cell lines derived from solid RT tumors."; RL J. Histochem. Cytochem. 49:1369-1378(2001). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=3518877; DOI=10.3109/07357908609038260; RA Fogh, Jorgen RT "Human tumor lines for cancer research."; RL Cancer Invest. 4:157-184(1986). // RX PubMed=24755471; DOI=10.1158/0008-5472.CAN-14-0013; RA Mouradov, Dmitri RA Sloggett, Clare RA Jorissen, Robert N. RA Love, Christopher G. RA Li, Shan RA Burgess, Antony Wilks RA Arango, Diego RA Strausberg, Robert L. RA Buchanan, Daniel RA Wormald, Samuel RA O'Connor, Liam RA Wilding, Jennifer L. RA Bicknell, David C. RA Tomlinson, Ian Philip Mark RA Bodmer, Walter Fred RA Mariadason, John M. RA Sieber, Oliver M. RT "Colorectal cancer cell lines are representative models of the main RT molecular subtypes of primary cancer."; RL Cancer Res. 74:3238-3247(2014). // RX PubMed=20831567; DOI=10.1111/j.1582-4934.2010.01170.x; PMCID=PMC3918049; RA Ma, Yan-Lei RA Zhang, Peng RA Wang, Feng RA Moyer, Mary Pat RA Yang, Jian-Jun RA Liu, Zhi-Hua RA Peng, Jiang-Yun RA Chen, Hong-Qi RA Zhou, Yu-Kun RA Liu, Wei-Jie RA Qin, Huan-Long RT "Human embryonic stem cells and metastatic colorectal cancer cells RT shared the common endogenous human microRNA-26b."; RL J. Cell. Mol. Med. 15:1941-1954(2011). // RX PubMed=3349466; RA Chantret, Isabelle RA Barbat, Alain RA Dussaulx, Elisabeth RA Brattain, Michael G. RA Zweibaum, Alain RT "Epithelial polarity, villin expression, and enterocytic RT differentiation of cultured human colon carcinoma cells: a survey of RT twenty cell lines."; RL Cancer Res. 48:1936-1942(1988). // RX PubMed=10092214; DOI=10.1002/(SICI)1097-4652(199812)177:4<618::AID-JCP12>3.0.CO;2-R; RA Levy, Peguy RA Robin, Helene RA Kornprobst, Michel RA Capeau, Jacqueline RA Cherqui, Gisele RT "Enterocytic differentiation of the human Caco-2 cell line correlates RT with alterations in integrin signaling."; RL J. Cell. Physiol. 177:618-627(1998). // RX PubMed=21607810; DOI=10.1208/s12248-011-9283-8; PMCID=PMC3160153; RA Borchardt, Ronald T. RT "Hidalgo, I.J., Raub, T.J., and Borchardt, R.T.: Characterization RT of the human colon carcinoma cell line (Caco-2) as a model system for RT intestinal epithelial permeability, Gastroenterology, 96, 736-749, RT 1989 -- the backstory."; RL AAPS J. 13:323-327(2011). // RX PubMed=25926053; DOI=10.1038/ncomms8002; RA Medico, Enzo RA Russo, Mariangela RA Picco, Gabriele RA Cancelliere, Carlotta RA Valtorta, Emanuele RA Corti, Giorgio RA Buscarino, Michela RA Isella, Claudio RA Lamba, Simona RA Martinoglio, Barbara RA Veronese, Silvio RA Siena, Salvatore RA Sartore-Bianchi, Andrea RA Beccuti, Marco RA Mottolese, Marcella RA Linnebacher, Michael RA Cordero, Francesca RA Di Nicolantonio, Federica RA Bardelli, Alberto RT "The molecular landscape of colorectal cancer cell lines unveils RT clinically actionable kinase targets."; RL Nat. Commun. 6:7002.1-7002.10(2015). // RX PubMed=10737795; DOI=10.1073/pnas.97.7.3352; PMCID=PMC16243; RA Rowan, Andrew J. RA Lamlum, Hanan RA Ilyas, Mohammad RA Wheeler, James M.D. RA Straub, Jannes RA Papadopoulou, Angeliki RA Bicknell, David C. RA Bodmer, Walter Fred RA Tomlinson, Ian Philip Mark RT "APC mutations in sporadic colorectal tumors: a mutational 'hotspot' RT and interdependence of the 'two hits'."; RL Proc. Natl. Acad. Sci. U.S.A. 97:3352-3357(2000). // RX PubMed=24042735; DOI=10.1038/oncsis.2013.35; PMCID=PMC3816225; RA Ahmed, Deeqa RA Eide, Peter W. RA Eilertsen, Ina A. RA Danielsen, Stine A. RA Eknaes, Mette RA Hektoen, Merete RA Lind, Guro Elisabeth RA Lothe, Ragnhild Adelheid RT "Epigenetic and genetic features of 24 colon cancer cell lines."; RL Oncogenesis 2:e71.1-e71.8(2013). // RX PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459; RA Masters, John R.W. RA Thomson, Jim A. RA Daly-Burns, Bernadette RA Reid, Yvonne A. RA Dirks, Wilhelm Gerhard RA Packer, Phil RA Toji, Lorraine H. RA Ohno, Tadao RA Tanabe, Hideyuki RA Arlett, Colin Francis RA Kelland, Lloyd R. RA Harrison, Maureen RA Virmani, Arvind K. RA Ward, Timothy H. RA Ayres, Karen L. RA Debenham, Paul G. RT "Short tandem repeat profiling provides an international reference RT standard for human cell lines."; RL Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001). // RX PubMed=18258742; DOI=10.1073/pnas.0712176105; PMCID=PMC2268141; RA Emaduddin, Muhammad RA Bicknell, David C. RA Bodmer, Walter Fred RA Feller, Stephan M. RT "Cell growth, global phosphotyrosine elevation, and c-Met RT phosphorylation through Src family kinases in colorectal cancer RT cells."; RL Proc. Natl. Acad. Sci. U.S.A. 105:2358-2362(2008). // RX PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076; RA Li, Jun RA Zhao, Wei RA Akbani, Rehan RA Liu, Wen-Bin RA Ju, Zhen-Lin RA Ling, Shi-Yun RA Vellano, Christopher P. RA Roebuck, Paul RA Yu, Qing-Hua RA Eterovic, A. Karina RA Byers, Lauren Averett RA Davies, Michael A. RA Deng, Wan-Leng RA Gopal, Y.N. Vashisht RA Chen, Guo RA von Euw, Erika Maria RA Slamon, Dennis Joseph RA Conklin, Dylan RA Heymach, John Victor RA Gazdar, Adi F. RA Minna, John D. RA Myers, Jeffrey N. RA Lu, Yi-Ling RA Mills, Gordon B. RA Liang, Han RT "Characterization of human cancer cell lines by reverse-phase protein RT arrays."; RL Cancer Cell 31:225-239(2017). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=23272949; DOI=10.1186/1755-8794-5-66; PMCID=PMC3543849; RA Schlicker, Andreas RA Beran, Garry RA Chresta, Christine M. RA McWalter, Gael RA Pritchard, Alison RA Weston, Susie RA Runswick, Sarah RA Davenport, Sara RA Heathcote, Kerry RA Castro, Denis Alferez RA Orphanides, George RA French, Tim RA Wessels, Lodewyk F.A. RT "Subtypes of primary colorectal tumors correlate with response to RT targeted treatment in colorectal cell lines."; RL BMC Med. Genomics 5:66.1-66.15(2012). // RX PubMed=16418264; DOI=10.1073/pnas.0510146103; PMCID=PMC1327731; RA Liu, Ying RA Bodmer, Walter Fred RT "Analysis of p53 mutations and their expression in 56 colorectal RT cancer cell lines."; RL Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006). // RX PubMed=7764660; DOI=10.1007/BF00749813; RA Hashimoto, Kei RA Shimizu, Makoto RT "Epithelial properties of human intestinal Caco-2 cells cultured in a RT serum-free medium."; RL Cytotechnology 13:175-184(1993). // RX PubMed=2914637; DOI=10.1016/0016-5085(89)90897-4; RA Hidalgo, Ismael J. RA Raub, Thomas J. RA Borchardt, Ronald T. RT "Characterization of the human colon carcinoma cell line (Caco-2) as a RT model system for intestinal epithelial permeability."; RL Gastroenterology 96:736-749(1989). // RX PubMed=31981602; DOI=10.1016/j.tiv.2020.104773; RA O'Doherty, Charles RA Keenan, Joanne RA Henry, Michael RA Meleady, Paula RA Sinkunaite, Indre RA Clynes, Martin RA O'Sullivan, Finbarr RA Horgan, Karina RA Murphy, Richard RT "Characterisation and proteomic profiling of continuously exposed RT Cu-resistant variants of the Caco-2 cell line."; RL Toxicol. In Vitro 65:104773.1-104773.14(2020). // RX PubMed=9294210; DOI=10.1073/pnas.94.19.10330; PMCID=PMC23362; RA Ilyas, Mohammad RA Tomlinson, Ian Philip Mark RA Rowan, Andrew J. RA Pignatelli, Massimo RA Bodmer, Walter Fred RT "Beta-catenin mutations in cell lines established from human RT colorectal cancers."; RL Proc. Natl. Acad. Sci. U.S.A. 94:10330-10334(1997). // RX PubMed=15731278; DOI=10.1128/JVI.79.6.3846-3850.2005; PMCID=PMC1075706; RA Mossel, Eric C. RA Huang, Cheng RA Narayanan, Krishna RA Makino, Shinji RA Tesh, Robert B. RA Peters, Clarence James RT "Exogenous ACE2 expression allows refractory cell lines to support RT severe acute respiratory syndrome coronavirus replication."; RL J. Virol. 79:3846-3850(2005). // RX PubMed=33389257; DOI=10.1007/s10096-020-04106-0; PMCID=PMC7778494; RA Wurtz, Nathalie RA Penant, Gwilherm RA Jardot, Priscilla RA Duclos, Nathalie RA La Scola, Bernard RT "Culture of SARS-CoV-2 in a panel of laboratory cell lines, RT permissivity, and differences in growth profile."; RL Eur. J. Clin. Microbiol. Infect. Dis. 40:477-484(2021). // RX PubMed=833871; DOI=10.1093/jnci/58.2.209; RA Fogh, Jorgen RA Wright, William C. RA Loveless, James D. RT "Absence of HeLa cell contamination in 169 cell lines derived from RT human tumors."; RL J. Natl. Cancer Inst. 58:209-214(1977). // RX PubMed=8508948; DOI=10.1111/j.1432-0436.1993.tb00645.x; RA de Bruine, Adriaan P. RA de Vries, Jan E. RA Dinjens, Winand N.M. RA Moerkerk, Peter T.M. RA van der Linden, Edith P.M. RA Pijls, Margriet M.J. RA ten Kate, Joop RA Bosman, Fred Theodoor RT "Human Caco-2 cells transfected with c-Ha-Ras as a model for endocrine RT differentiation in the large intestine."; RL Differentiation 53:51-60(1993). // RX PubMed=10612807; DOI=10.1002/(SICI)1098-2264(200002)27:2<183::AID-GCC10>3.0.CO;2-P; PMCID=PMC4721570; RA Ghadimi, B. Michael RA Sackett, Dan L. RA Difilippantonio, Michael J. RA Schrock, Evelin RA Neumann, Thomas RA Jauho, Annukka RA Auer, Gert RA Ried, Thomas RT "Centrosome amplification and instability occurs exclusively in RT aneuploid, but not in diploid colorectal cancer cell lines, and RT correlates with numerical chromosomal aberrations."; RL Genes Chromosomes Cancer 27:183-190(2000). // RX PubMed=34339474; DOI=10.1371/journal.pone.0255622; PMCID=PMC8328321; RA Pommerenke, Claudia RA Rand, Ulfert RA Uphoff, Cord C. RA Nagel, Stefan RA Zaborski, Margarete RA Hauer, Vivien RA Kaufmann, Maren RA Meyer, Corinna RA Denkmann, Sabine A. RA Riese, Peggy RA Eschke, Kathrin RA Kim, Yeonsu RA Safranko, Zeljka Macak RA Kurolt, Ivan-Christian RA Markotic, Alemka RA Cicin-Sain, Luka RA Steenpass, Laura RT "Identification of cell lines CL-14, CL-40 and CAL-51 as suitable RT models for SARS-CoV-2 infection studies."; RL PLoS ONE 16:e0255622.1-e0255622.15(2021). // RX PubMed=11414198; DOI=10.1007/s004320000207; RA Lahm, Harald RA Andre, Sabine RA Hoeflich, Andreas RA Fischer, Jurgen R. RA Sordat, Bernard RA Kaltner, Herbert RA Wolf, Eckhard RA Gabius, Hans-Joachim RT "Comprehensive galectin fingerprinting in a panel of 61 human tumor RT cell lines by RT-PCR and its implications for diagnostic and RT therapeutic procedures."; RL J. Cancer Res. Clin. Oncol. 127:375-386(2001). //