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Cellosaurus Caco-2MT (CVCL_C8JJ)

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Cell line name Caco-2MT
Accession CVCL_C8JJ
Resource Identification Initiative To cite this cell line use: Caco-2MT (RRID:CVCL_C8JJ)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transfection; Gene=UniProtKB; P03077; Murine polyomavirus (strain A2) (MPyV) middle T antigen (PyMT).
Transformant: NCBI_TaxID; 10636; Murine polyomavirus (strain A2) (MPyV).
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0025 (Caco-2)
Sex of cell Male
Age at sampling 72Y
Category Cancer cell line
Publications

PubMed=8253353; DOI=10.1016/0016-5085(93)91076-t
Eric Chastre, Sylvie Empereur, Yolande Di Gioia, Nour-Eddine El Mahdani, Marc M. Mareel, Kris L. Vleminckx, Frans M. Van Roy, Valerie Bex, Shahin Emami, Demetrios A. Spandidos, Christian Gespach;
Neoplastic progression of human and rat intestinal cell lines after transfer of the ras and polyoma middle T oncogenes.
Gastroenterology 105:1776-1789(1993)

Cross-references
Encyclopedic resources Wikidata; Q123030848
Entry history
Entry creation05-Oct-2023
Last entry update27-Nov-2025
Version number6