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Cellosaurus Caco-2 DUSP6 KO (CVCL_C0R8)

[Text version]
Cell line name Caco-2 DUSP6 KO
Synonyms DUSP6 KO Caco-2
Accession CVCL_C0R8
Resource Identification Initiative To cite this cell line use: Caco-2 DUSP6 KO (RRID:CVCL_C0R8)
Comments Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; 3072; DUSP6.
Omics: Deep phosphoproteome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0025 (Caco-2)
Sex of cell Male
Age at sampling 72Y
Category Cancer cell line

PubMed=27892926; DOI=10.1038/nmicrobiol.2016.220
Ruan J.-W., Statt S., Huang C.-T., Tsai Y.-T., Kuo C.-C., Chan H.-L., Liao Y.-C., Tan T.-H., Kao C.-Y.
Dual-specificity phosphatase 6 deficiency regulates gut microbiome and transcriptome response against diet-induced obesity in mice.
Nat. Microbiol. 2:16220.1-16220.12(2016)

PubMed=34818535; DOI=10.1016/j.celrep.2021.110016
Chang C.-S., Liao Y.-C., Huang C.-T., Lin C.-M., Cheung C.H.-Y., Ruan J.-W., Yu W.-H., Tsai Y.-T., Lin I.-J., Huang C.-H., Liou J.-S., Chou Y.-H., Chien H.-J., Chuang H.-L., Juan H.-F., Huang H.-C., Chan H.-L., Liao Y.-C., Tang S.-C., Su Y.-W., Tan T.-H., Baumler A.J., Kao C.-Y.
Identification of a gut microbiota member that ameliorates DSS-induced colitis in intestinal barrier enhanced Dusp6-deficient mice.
Cell Rep. 37:110016.1-110016.26(2021)

Cell line databases/resources cancercelllines; CVCL_C0R8
Encyclopedic resources Wikidata; Q112929357
Proteomic databases PRIDE; PXD029014
Entry history
Entry creation23-Jun-2022
Last entry update05-Oct-2023
Version number5