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Cellosaurus Caco-2 DUSP6 KO (CVCL_C0R8)

[Text version]
Cell line name Caco-2 DUSP6 KO
Synonyms DUSP6 KO Caco-2
Accession CVCL_C0R8
Resource Identification Initiative To cite this cell line use: Caco-2 DUSP6 KO (RRID:CVCL_C0R8)
Comments Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:3072; DUSP6.
Omics: Proteomics; PTM; Phosphorylation.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0025 (Caco-2)
Sex of cell Male
Age at sampling 72Y
Category Cancer cell line
Publications

PubMed=27892926; DOI=10.1038/nmicrobiol.2016.220
Jhen-Wei Ruan, Sarah Statt, Chih-Ting Huang, Yi-Ting Tsai, Cheng-Chin Kuo, Hong-Lin Chan, Yu-Chieh Liao, Tse-Hua Tan, Cheng-Yuan Kao;
Dual-specificity phosphatase 6 deficiency regulates gut microbiome and transcriptome response against diet-induced obesity in mice.
Nat. Microbiol. 2:16220.1-16220.12(2016)

PubMed=34818535; DOI=10.1016/j.celrep.2021.110016
Cherng-Shyang Chang, Yi-Chu Liao, Chih-Ting Huang, Chiao-Mei Lin, Chantal Hoi-Yin Cheung, Jhen-Wei Ruan, Wen-Hsuan Yu, Yi-Ting Tsai, I-Jung Lin, Chien-Hsun Huang, Jong-Shian Liou ...Show all 23 authors... , Ya-Hsien Chou, Hung-Jen Chien, Hsiao-Li Chuang, Hsueh-Fen Juan, Hsuan-Cheng Huang, Hong-Lin Chan, Yu-Chieh Liao, Shiue-Cheng Tang, Yu-Wen Su, Tse-Hua Tan, Andreas J. Baumler, Cheng-Yuan Kao; Show fewer authors
Identification of a gut microbiota member that ameliorates DSS-induced colitis in intestinal barrier enhanced Dusp6-deficient mice.
Cell Rep. 37:110016.1-110016.26(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C0R8
Encyclopedic resources Wikidata; Q112929357
Proteomic databases PRIDE; PXD029014
Entry history
Entry creation23-Jun-2022
Last entry update10-Apr-2025
Version number7