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Cellosaurus Caco-2 EJ6 (CVCL_C8A0)

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Cell line name Caco-2 EJ6
Accession CVCL_C8A0
Resource Identification Initiative To cite this cell line use: Caco-2 EJ6 (RRID:CVCL_C8A0)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0025 (Caco-2)
Sex of cell Male
Age at sampling 72Y
Category Cancer cell line
Publications

PubMed=8508948; DOI=10.1111/j.1432-0436.1993.tb00645.x
Adriaan P. de Bruine, Jan E. de Vries, Winand N.M. Dinjens, Peter T.M. Moerkerk, Edith P.M. van der Linden, Margriet M.J. Pijls, Joop ten Kate, Fred Theodoor Bosman;
Human Caco-2 cells transfected with c-Ha-Ras as a model for endocrine differentiation in the large intestine.
Differentiation 53:51-60(1993)

Cross-references
Encyclopedic resources Wikidata; Q123030843
Entry history
Entry creation29-Jun-2023
Last entry update14-Aug-2025
Version number5