ID   Caco-2 EJ6
AC   CVCL_C8A0
DR   Wikidata; Q123030843
RX   PubMed=8508948;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (from parent cell line).
CC   Transfected with: HGNC; 5173; HRAS (with p.Gly12Val).
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0025 ! Caco-2
SX   Male
AG   72Y
CA   Cancer cell line
DT   Created: 29-06-23; Last updated: 30-01-24; Version: 2
//
RX   PubMed=8508948; DOI=10.1111/j.1432-0436.1993.tb00645.x;
RA   de Bruine A.P., de Vries J.E., Dinjens W.N.M., Moerkerk P.T.M.,
RA   van der Linden E.P.M., Pijls M.M.J., ten Kate J., Bosman F.T.;
RT   "Human Caco-2 cells transfected with c-Ha-Ras as a model for endocrine
RT   differentiation in the large intestine.";
RL   Differentiation 53:51-60(1993).
//