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Cellosaurus Caco-2/PD-7 (CVCL_Z580)

[Text version]
Cell line name Caco-2/PD-7
Synonyms Caco-2/PD7; Caco2/PD7; PD-7; PD7
Accession CVCL_Z580
Resource Identification Initiative To cite this cell line use: Caco-2/PD-7 (RRID:CVCL_Z580)
Comments Population: Caucasian.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0025 (Caco-2)
Sex of cell Male
Age at sampling 72Y
Category Cancer cell line

PubMed=8175910; DOI=10.1242/jcs.107.1.213
Chantret I., Rodolosse A., Barbat A., Dussaulx E., Brot-Laroche E., Zweibaum A., Rousset M.
Differential expression of sucrase-isomaltase in clones isolated from early and late passages of the cell line Caco-2: evidence for glucose-dependent negative regulation.
J. Cell Sci. 107:213-225(1994)

Caro I., Boulenc X., Rousset M., Meunier V., Bourrie M., Julian B., Joyeux H., Roques C., Berger Y., Zweibaum A., Fabre G.
Characterisation of a newly isolated Caco-2 clone (TC-7), as a model of transport processes and biotransformation of drugs.
Int. J. Pharmaceut. 116:147-158(1995)

PubMed=15868485; DOI=10.1007/s10565-005-0085-6
Sambuy Y., De Angelis I., Ranaldi G., Scarino M.L., Stammati A., Zucco F.
The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics.
Cell Biol. Toxicol. 21:1-26(2005)

Cell line databases/resources cancercelllines; CVCL_Z580
Encyclopedic resources Wikidata; Q54808326
Entry history
Entry creation10-Apr-2015
Last entry update05-Oct-2023
Version number12