| Cell line name |
Caco-2-ACE2 |
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| Accession |
CVCL_C9AR |
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| Resource Identification Initiative |
To cite this cell line use: Caco-2-ACE2 (RRID:CVCL_C9AR) |
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| Comments |
Group: SARS-CoV-2 research cell line.
Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:13557; ACE2.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:13557; ACE2.
Omics: Phenotyping; CRISPR screening.
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
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| Sequence variations |
- Mutation; HGNC; HGNC:583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Colon adenocarcinoma (NCIt: C4349) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0025 (Caco-2) |
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| Sex of cell |
Male |
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| Age at sampling |
72Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=35879413; DOI=10.1038/s41588-022-01110-2
Antoine Rebendenne, Priyanka Roy, Boris Bonaventure, Ana Luiza Chaves Valadao, Lowiese M.B. Desmarets, Mary Arnaud-Arnould, Yves Rouille, Marine Tauziet, Donatella Giovannini, Jawida Touhami, Yenarae Lee ...Show all 23 authors... , Peter DeWeirdt, Mudra Hegde, Serge Urbach, Khadija El Koulali, Francisco Garcia de Gracia, Joe McKellar, Jean Dubuisson, Melanie Wencker, Sandrine Belouzard, Olivier Moncorge, John G. Doench, Caroline Goujon; Show fewer authors
Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs.
Nat. Genet. 54:1090-1102(2022) |
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| Cross-references |
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| CRISP screens repositories |
BioGRID_ORCS_Cell_line; 1691
|
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| Encyclopedic resources |
Wikidata; Q123030845
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| Entry history |
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| Entry creation | 05-Oct-2023 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 5 |
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