ID   Caco-2-ACE2
AC   CVCL_C9AR
DR   BioGRID_ORCS_Cell_line; 1691
DR   Wikidata; Q123030845
RX   PubMed=35879413;
CC   Group: SARS-CoV-2 research cell line.
CC   Population: Caucasian.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:13557; ACE2.
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:13557; ACE2.
CC   Omics: Phenotyping; CRISPR screening.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0025 ! Caco-2
SX   Male
AG   72Y
CA   Cancer cell line
DT   Created: 05-10-23; Last updated: 10-04-25; Version: 5
//
RX   PubMed=35879413; DOI=10.1038/s41588-022-01110-2;
RA   Rebendenne, Antoine
RA   Roy, Priyanka
RA   Bonaventure, Boris
RA   Chaves Valadao, Ana Luiza
RA   Desmarets, Lowiese M.B.
RA   Arnaud-Arnould, Mary
RA   Rouille, Yves
RA   Tauziet, Marine
RA   Giovannini, Donatella
RA   Touhami, Jawida
RA   Lee, Yenarae
RA   DeWeirdt, Peter
RA   Hegde, Mudra
RA   Urbach, Serge
RA   El Koulali, Khadija
RA   de Gracia, Francisco Garcia
RA   McKellar, Joe
RA   Dubuisson, Jean
RA   Wencker, Melanie
RA   Belouzard, Sandrine
RA   Moncorge, Olivier
RA   Doench, John G.
RA   Goujon, Caroline
RT   "Bidirectional genome-wide CRISPR screens reveal host factors
RT   regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs.";
RL   Nat. Genet. 54:1090-1102(2022).
//