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Cellosaurus Caco-2-RCAr clone 2 (CVCL_HA82)

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Cell line name Caco-2-RCAr clone 2
Accession CVCL_HA82
Resource Identification Initiative To cite this cell line use: Caco-2-RCAr clone 2 (RRID:CVCL_HA82)
Comments Population: Caucasian.
Selected for resistance to: UniProtKB; P02879; Ricinus communis ricin.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0025 (Caco-2)
Sex of cell Male
Age at sampling 72Y
Category Cancer cell line
Publications

PubMed=10393089; DOI=10.1042/bj3410323; PMCID=PMC1220363
Mark R. Jackman, Juliet A. Ellis, Sally R. Gray, Wenda Shurety, John Paul Luzio;
Cell polarization is required for ricin sensitivity in a Caco-2 cell line selected for ricin resistance.
Biochem. J. 341:323-327(1999)

Cross-references
Cell line databases/resources cancercelllines; CVCL_HA82
Encyclopedic resources Wikidata; Q54808319
Entry history
Entry creation01-Dec-2016
Last entry update19-Dec-2024
Version number13