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Cellosaurus HL60-CDR (CVCL_C1LK)

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Cell line name HL60-CDR
Accession CVCL_C1LK
Resource Identification Initiative To cite this cell line use: HL60-CDR (RRID:CVCL_C1LK)
Comments Population: Caucasian.
Characteristics: Resistant to doxorubicin, cisplatin, etoposide and daunorubicin (PubMed=35822500).
Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute myeloid leukemia with maturation (NCIt: C7961)
Acute myeloblastic leukemia with maturation (ORDO: Orphanet_98834)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0002 (HL-60)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
Publications

PubMed=35822500; DOI=10.1080/1120009X.2022.2097432
Ines Castro, Vanessa Lopes-Rodrigues, Helena Branco, M. Helena Vasconcelos, Cristina P.R. Xavier;
Establishing and characterizing a novel doxorubicin-resistant acute myeloid leukaemia cell line.
J. Chemother. 35:307-321(2023)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C1LK
Encyclopedic resources Wikidata; Q114311625
Entry history
Entry creation22-Sep-2022
Last entry update14-Aug-2025
Version number7