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Cellosaurus HL-60/AR (CVCL_WR44)

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Cell line name HL-60/AR
Accession CVCL_WR44
Resource Identification Initiative To cite this cell line use: HL-60/AR (RRID:CVCL_WR44)
Comments Group: Space-flown cell line (cellonaut).
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_48120; Anthracycline.
Anecdotal: Have been flown in space on shuttle flight STS-67 to study the effect of microgravity on multidrug resistance (PubMed=9434637).
Caution: Not to be confused with HL60/AR (Cellosaurus=CVCL_WI27) which is an 5-azacytidine resistant subline of HL-60.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute myeloid leukemia with maturation (NCIt: C7961)
Acute myeloblastic leukemia with maturation (ORDO: Orphanet_98834)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0002 (HL-60)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
Publications

PubMed=3860286
Kapil N. Bhalla, Alexander A. Hindenburg, Robert N. Taub, Steven Grant;
Isolation and characterization of an anthracycline-resistant human leukemic cell line.
Cancer Res. 45:3657-3662(1985)

PubMed=2545346
Alexander A. Hindenburg, James E. Gervasoni Jr., Sindu Krishna, Valerie J. Stewart, Michelle Rosado, Jose Lutzky, Kapil N. Bhalla, Michael A. Baker, Robert N. Taub;
Intracellular distribution and pharmacokinetics of daunorubicin in anthracycline-sensitive and -resistant HL-60 cells.
Cancer Res. 49:4607-4614(1989)

PubMed=9434637; DOI=10.1006/excr.1997.3813
Edward Harman Piepmeier, John E. Kalns, Kenneth M. McIntyre, Marian L. Lewis;
Prolonged weightlessness affects promyelocytic multidrug resistance.
Exp. Cell Res. 237:410-418(1997)

Cross-references
Cell line databases/resources cancercelllines; CVCL_WR44
Encyclopedic resources Wikidata; Q94211566
Entry history
Entry creation05-Jul-2019
Last entry update14-Aug-2025
Version number12