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Cellosaurus HL60/AR (CVCL_WI27)

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Cell line name HL60/AR
Synonyms HAR
Accession CVCL_WI27
Resource Identification Initiative To cite this cell line use: HL60/AR (RRID:CVCL_WI27)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_2038; 5-azacytidine (5-azaC).
Caution: Not to be confused with HL-60/AR (Cellosaurus=CVCL_WR44) which is an anthracycline resistant subline of HL-60.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute myeloid leukemia with maturation (NCIt: C7961)
Acute myeloblastic leukemia with maturation (ORDO: Orphanet_98834)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0002 (HL-60)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
Publications

PubMed=24368162; DOI=10.1016/j.exphem.2013.12.004
Piyanuch Sripayap, Tadashi Nagai, Mitsuyo Uesawa, Hiroyuki Kobayashi, Tomonori Tsukahara, Ken Ohmine, Kazuo Muroi, Keiya Ozawa;
Mechanisms of resistance to azacitidine in human leukemia cell lines.
Exp. Hematol. 42:294-306.e2(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_WI27
Encyclopedic resources Wikidata; Q94211961
Entry history
Entry creation24-May-2019
Last entry update14-Aug-2025
Version number13