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Cellosaurus HL60 Ast.4 (CVCL_2496)

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Cell line name HL60 Ast.4
Synonyms HL60 Ast 4; HL60 Ast4
Accession CVCL_2496
Resource Identification Initiative To cite this cell line use: HL60 Ast.4 (RRID:CVCL_2496)
Comments Population: Caucasian.
Transformant: NCIt; C129638; Astatine-211 alpha radiation.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute myeloid leukemia with maturation (NCIt: C7961)
Acute myeloblastic leukemia with maturation (ORDO: Orphanet_98834)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0002 (HL-60)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
STR profile Source(s): ECACC=88120802

Markers:
AmelogeninX
CSF1PO13,14
D5S81812
D7S82011,12
D13S3178,11
D16S53911
TH017,8
TPOX8,11
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=6641827
Christopher M. Bunce, Amanda Gay Fisher, Deniz Toksoz, Geoffrey Brown;
Isolation and characterisation of dimethylsulphoxide resistant variants from the human promyeloid cell line HL60.
Exp. Hematol. 11:828-833(1983)

PubMed=3165665; DOI=10.1038/bjc.1988.128; PMCID=PMC2246464
Christopher M. Bunce, Janet Mary Lord, A.K.-Y. Wong, Geoffrey Brown;
Near neighbour analysis of variant cell lines derived from the promyeloid cell line HL60.
Br. J. Cancer 57:559-563(1988)

Cross-references
Cell line collections (Providers) ECACC; 88120802
Cell line databases/resources CLO; CLO_0003778
CLDB; cl1696
cancercelllines; CVCL_2496
Encyclopedic resources Wikidata; Q54889827
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number27