ID   HL60 Ast.4
AC   CVCL_2496
SY   HL60 Ast 4; HL60 Ast4
DR   CLO; CLO_0003778
DR   CLDB; cl1696
DR   cancercelllines; CVCL_2496
DR   ECACC; 88120802
DR   Wikidata; Q54889827
RX   PubMed=3165665;
RX   PubMed=6641827;
CC   Population: Caucasian.
CC   Sequence variation: Gene deletion; HGNC; 11998; TP53; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Transformant: NCIt; C129638; Astatine-211 alpha radiation.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): ECACC=88120802
ST   Amelogenin: X
ST   CSF1PO: 13,14
ST   D13S317: 8,11
ST   D16S539: 11
ST   D5S818: 12
ST   D7S820: 11,12
ST   TH01: 7,8
ST   TPOX: 8,11
ST   vWA: 16
DI   NCIt; C9154; Adult acute myeloid leukemia
DI   ORDO; Orphanet_519; Acute myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0002 ! HL-60
SX   Female
AG   36Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 25
//
RX   PubMed=3165665; DOI=10.1038/bjc.1988.128;
RA   Bunce C.M., Lord J.M., Wong A.K.-Y., Brown G.;
RT   "Near neighbour analysis of variant cell lines derived from the
RT   promyeloid cell line HL60.";
RL   Br. J. Cancer 57:559-563(1988).
//
RX   PubMed=6641827;
RA   Bunce C.M., Fisher A.G., Toksoz D., Brown G.;
RT   "Isolation and characterisation of dimethylsulphoxide resistant
RT   variants from the human promyeloid cell line HL60.";
RL   Exp. Hematol. 11:828-833(1983).
//