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Cellosaurus HL-60 clone 15 (CVCL_2493)

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Cell line name HL-60 clone 15
Synonyms HL-60 clone15; Clone 15 HL-60
Accession CVCL_2493
Resource Identification Initiative To cite this cell line use: HL-60 clone 15 (RRID:CVCL_2493)
Comments Population: Caucasian.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute myeloid leukemia with maturation (NCIt: C7961)
Acute myeloblastic leukemia with maturation (ORDO: Orphanet_98834)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0002 (HL-60)
Children:
CVCL_2494 (HL-60 clone 15-12)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-1964; ECACC=98052918

Markers:
AmelogeninX
CSF1PO13,14
D2S133817
D3S135816
D5S81812
D7S82011,12
D8S117912,13
D13S3178,11
D16S53911
D18S5114,15
D19S43314
D21S1129,30
FGA22,24
Penta D10,12
Penta E13,14
TH017,8
TPOX8,11
vWA16

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Publications

PubMed=3184985; DOI=10.1016/0145-2126(88)90103-8
Steven A. Fischkoff;
Graded increase in probability of eosinophilic differentiation of HL-60 promyelocytic leukemia cells induced by culture under alkaline conditions.
Leuk. Res. 12:679-686(1988)

Cross-references
Cell line collections (Providers) ATCC; CRL-1964
BCRC; 60273
ECACC; 98052918
Cell line databases/resources CLO; CLO_0002499
CLDB; cl5151
cancercelllines; CVCL_2493
LINCS_LDP; LCL-1081
Encyclopedic resources Wikidata; Q54889798
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number32