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Cellosaurus HL-60 DeltaF508-CF (CVCL_WZ17)

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Cell line name HL-60 DeltaF508-CF
Synonyms DeltaF508-CF HL-60
Accession CVCL_WZ17
Resource Identification Initiative To cite this cell line use: HL-60 DeltaF508-CF (RRID:CVCL_WZ17)
Comments Population: Caucasian.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1884; CFTR; Simple_edited; p.Phe508del (c.1521_1523delCTT); ClinVar=VCV000007105; Zygosity=Homozygous; Note=By CRISPR/Cas9 (PubMed=30670178).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute myeloid leukemia with maturation (NCIt: C7961)
Acute myeloblastic leukemia with maturation (ORDO: Orphanet_98834)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0002 (HL-60)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
STR profile Source(s): Millipore=SCC251

Markers:
AmelogeninX
CSF1PO13,14
D3S135816
D5S81812
D7S82011,12
D8S117912,13
D13S3178,11
D16S53911
D18S5114,15
D21S1129,30
FGA22,24
Penta D10,12
Penta E13,14
TH017,8
TPOX8,11
vWA16

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Publications

PubMed=30670178; DOI=10.1016/j.jcf.2018.06.007
Scott Jennings, Hang Pong Ng, Guo-Shun Wang;
Establishment of a DeltaF508-CF promyelocytic cell line for cystic fibrosis research and drug screening.
J. Cyst. Fibros. 18:44-53(2019)

Cross-references
Cell line collections (Providers) Millipore; SCC251
Cell line databases/resources cancercelllines; CVCL_WZ17
Encyclopedic resources Wikidata; Q94211494
Entry history
Entry creation06-Sep-2019
Last entry update14-Aug-2025
Version number13