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Cellosaurus HL-60/MX1 (CVCL_3332)

[Text version]
Cell line name HL-60/MX1
Synonyms HL 60/MX1; HL-60/MX-1; HL60/MX1; HL60MX1
Accession CVCL_3332
Resource Identification Initiative To cite this cell line use: HL-60/MX1 (RRID:CVCL_3332)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_50729; Mitoxantrone.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute myeloid leukemia with maturation (NCIt: C7961)
Acute myeloblastic leukemia with maturation (ORDO: Orphanet_98834)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0002 (HL-60)
Children:
CVCL_3333 (HL-60/MX2)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2258

Markers:
AmelogeninX
CSF1PO13,14
D2S133817
D3S135816
D5S81812
D7S82011,12
D8S117911,13
D13S3178,11
D16S53911
D18S5114
D19S43314
D21S1129,30
FGA22,24
Penta D10,12
Penta E13,14
TH017,8
TPOX8
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=2568172
W. Graydon Harker, D. Lynn Slade, William S. Dalton, Paul S. Meltzer, Jeffrey M. Trent;
Multidrug resistance in mitoxantrone-selected HL-60 leukemia cells in the absence of P-glycoprotein overexpression.
Cancer Res. 49:4542-4549(1989)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

Cross-references
Cell line collections (Providers) ATCC; CRL-2258
NCBI_Iran; C553
Cell line databases/resources CLO; CLO_0003781
cancercelllines; CVCL_3332
IGRhCellID; HL60MX1
Biological sample resources BioSample; SAMN03471850
Encyclopedic resources Wikidata; Q54889805
Gene expression databases ArrayExpress; E-MTAB-38
Polymorphism and mutation databases Progenetix; CVCL_3332
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number31