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Cellosaurus HL-60/MX1 (CVCL_3332)

[Text version]
Cell line name HL-60/MX1
Synonyms HL 60/MX1; HL-60/MX-1; HL60/MX1; HL60MX1
Accession CVCL_3332
Resource Identification Initiative To cite this cell line use: HL-60/MX1 (RRID:CVCL_3332)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:50729; Mitoxantrone.
Omics: SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; 11998; TP53; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0002 (HL-60)
Children:
CVCL_3333 (HL-60/MX2)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
STR profile Source(s): ATCC

Markers:
AmelogeninX
CSF1PO13,14
D5S81812
D7S82011,12
D13S3178,11
D16S53911
TH017,8
TPOX8
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=2568172
Harker W.G., Slade D.L., Dalton W.S., Meltzer P.S., Trent J.M.
Multidrug resistance in mitoxantrone-selected HL-60 leukemia cells in the absence of P-glycoprotein overexpression.
Cancer Res. 49:4542-4549(1989)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

Cross-references
Cell line collections (Providers) ATCC; CRL-2258
NCBI_Iran; C553
Cell line databases/resources CLO; CLO_0003781
cancercelllines; CVCL_3332
IGRhCellID; HL60MX1
Biological sample resources BioSample; SAMN03471850
Encyclopedic resources Wikidata; Q54889805
Gene expression databases ArrayExpress; E-MTAB-38
Polymorphism and mutation databases Progenetix; CVCL_3332
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number27