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Cellosaurus HL-60/MX2 (CVCL_3333)

[Text version]
Cell line name HL-60/MX2
Synonyms HL-60/MX-2; HL60/MX2
Accession CVCL_3333
Resource Identification Initiative To cite this cell line use: HL-60/MX2 (RRID:CVCL_3333)
Comments Population: Caucasian.
Doubling time: 30 hours (ATCC=CRL-2257).
Selected for resistance to: ChEBI; CHEBI:50729; Mitoxantrone.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; 11998; TP53; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_3332 (HL-60/MX1)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
STR profile Source(s): ATCC

Markers:
AmelogeninX
CSF1PO13,14
D5S81812
D7S82011,12
D13S3178,11
D16S53911
TH017,8
TPOX8,11
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=2568172
Harker W.G., Slade D.L., Dalton W.S., Meltzer P.S., Trent J.M.
Multidrug resistance in mitoxantrone-selected HL-60 leukemia cells in the absence of P-glycoprotein overexpression.
Cancer Res. 49:4542-4549(1989)

Cross-references
Cell line collections (Providers) ATCC; CRL-2257
Cell line databases/resources CLO; CLO_0003782
cancercelllines; CVCL_3333
LINCS_LDP; LCL-1083
Anatomy/cell type resources BTO; BTO:0003571
Chemistry resources ChEMBL-Cells; CHEMBL4295458
ChEMBL-Targets; CHEMBL4296431
PubChem_Cell_line; CVCL_3333
Encyclopedic resources Wikidata; Q54889806
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number29