Cellosaurus logo
expasy logo

Cellosaurus HL-60/MX2 (CVCL_3333)

[Text][XML][JSON]
Cell line name HL-60/MX2
Synonyms HL-60/MX-2; HL60/MX2
Accession CVCL_3333
Resource Identification Initiative To cite this cell line use: HL-60/MX2 (RRID:CVCL_3333)
Comments Population: Caucasian.
Doubling time: ~30 hours (ATCC=CRL-2257).
Selected for resistance to: ChEBI; CHEBI_50729; Mitoxantrone.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute myeloid leukemia with maturation (NCIt: C7961)
Acute myeloblastic leukemia with maturation (ORDO: Orphanet_98834)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_3332 (HL-60/MX1)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2257

Markers:
AmelogeninX
CSF1PO13,14
D2S133817
D3S135816
D5S81812
D7S82011,12
D8S117912,13
D13S3178,11
D16S53911
D18S5114
D19S43314
D21S1129,30
FGA22,24
Penta D10,12
Penta E13,14
TH017,8
TPOX8,11
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=2568172
W. Graydon Harker, D. Lynn Slade, William S. Dalton, Paul S. Meltzer, Jeffrey M. Trent;
Multidrug resistance in mitoxantrone-selected HL-60 leukemia cells in the absence of P-glycoprotein overexpression.
Cancer Res. 49:4542-4549(1989)

Cross-references
Cell line collections (Providers) ATCC; CRL-2257
Cell line databases/resources CLO; CLO_0003782
cancercelllines; CVCL_3333
LINCS_LDP; LCL-1083
Anatomy/cell type resources BTO; BTO_0003571
Chemistry resources ChEMBL-Cells; CHEMBL4295458
ChEMBL-Targets; CHEMBL4296431
PubChem_Cell_line; CVCL_3333
Encyclopedic resources Wikidata; Q54889806
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number32