ID   HL-60/MX1
AC   CVCL_3332
SY   HL 60/MX1; HL-60/MX-1; HL60/MX1; HL60MX1
DR   CLO; CLO_0003781
DR   ArrayExpress; E-MTAB-38
DR   ATCC; CRL-2258
DR   BioSample; SAMN03471850
DR   cancercelllines; CVCL_3332
DR   IGRhCellID; HL60MX1
DR   NCBI_Iran; C553
DR   Progenetix; CVCL_3332
DR   Wikidata; Q54889805
RX   PubMed=2568172;
RX   PubMed=20215515;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI_50729; Mitoxantrone.
CC   Sequence variation: Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Omics: Variations; SNP array analysis.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): ATCC=CRL-2258
ST   Amelogenin: X
ST   CSF1PO: 13,14
ST   D13S317: 8,11
ST   D16S539: 11
ST   D18S51: 14
ST   D19S433: 14
ST   D21S11: 29,30
ST   D2S1338: 17
ST   D3S1358: 16
ST   D5S818: 12
ST   D7S820: 11,12
ST   D8S1179: 11,13
ST   FGA: 22,24
ST   Penta D: 10,12
ST   Penta E: 13,14
ST   TH01: 7,8
ST   TPOX: 8
ST   vWA: 16
DI   NCIt; C7961; Adult acute myeloid leukemia with maturation
DI   ORDO; Orphanet_98834; Acute myeloblastic leukemia with maturation
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0002 ! HL-60
SX   Female
AG   36Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 14-08-25; Version: 31
CH   CVCL_3333 ! HL-60/MX2
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=2568172;
RA   Harker, W. Graydon
RA   Slade, D. Lynn
RA   Dalton, William S.
RA   Meltzer, Paul S.
RA   Trent, Jeffrey M.
RT   "Multidrug resistance in mitoxantrone-selected HL-60 leukemia cells in
RT   the absence of P-glycoprotein overexpression.";
RL   Cancer Res. 49:4542-4549(1989).
//