Cellosaurus cell line HL60 M4 (CVCL

Cellosaurus HL60 M4 (CVCL_2498)

Cross-references
Cell line name	HL60 M4
Synonyms	HL60 m4; HL60M4; HL60m4
Accession	CVCL_2498
Resource Identification Initiative	To cite this cell line use: HL60 M4 (RRID:CVCL_2498)
Comments	Population: Caucasian. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations	Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease	Adult acute myeloid leukemia with maturation (NCIt: C7961) Acute myeloblastic leukemia with maturation (ORDO: Orphanet_98834)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0002 (HL-60)
Sex of cell	Female
Age at sampling	36Y
Category	Cancer cell line
Publications	PubMed=6958930; DOI=10.1016/0145-2126(82)90006-6 Deniz Toksoz, Christopher M. Bunce, Philip C.W. Stone, Robert Hall Michell, Geoffrey Brown; Variant cell lines from the human promyelocyte line HL60. Leuk. Res. 6:491-498(1982) PubMed=6641827 Christopher M. Bunce, Amanda Gay Fisher, Deniz Toksoz, Geoffrey Brown; Isolation and characterisation of dimethylsulphoxide resistant variants from the human promyeloid cell line HL60. Exp. Hematol. 11:828-833(1983) PubMed=3165665; DOI=10.1038/bjc.1988.128; PMCID=PMC2246464 Christopher M. Bunce, Janet Mary Lord, A.K.-Y. Wong, Geoffrey Brown; Near neighbour analysis of variant cell lines derived from the promyeloid cell line HL60. Br. J. Cancer 57:559-563(1988)
Cell line collections (Providers)	ECACC; 88120804
Cell line databases/resources	CLO; CLO_0003780 CLDB; cl1698 cancercelllines; CVCL_2498
Encyclopedic resources	Wikidata; Q54889829
Entry history
Entry creation	04-Apr-2012
Last entry update	14-Aug-2025
Version number	24