ID   HL60 M4
AC   CVCL_2498
SY   HL60 m4; HL60M4; HL60m4
DR   CLO; CLO_0003780
DR   CLDB; cl1698
DR   cancercelllines; CVCL_2498
DR   ECACC; 88120804
DR   Wikidata; Q54889829
RX   PubMed=3165665;
RX   PubMed=6641827;
RX   PubMed=6958930;
CC   Population: Caucasian.
CC   Sequence variation: Gene deletion; HGNC; 11998; TP53; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9154; Adult acute myeloid leukemia
DI   ORDO; Orphanet_519; Acute myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0002 ! HL-60
SX   Female
AG   36Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 22
//
RX   PubMed=3165665; DOI=10.1038/bjc.1988.128;
RA   Bunce C.M., Lord J.M., Wong A.K.-Y., Brown G.;
RT   "Near neighbour analysis of variant cell lines derived from the
RT   promyeloid cell line HL60.";
RL   Br. J. Cancer 57:559-563(1988).
//
RX   PubMed=6641827;
RA   Bunce C.M., Fisher A.G., Toksoz D., Brown G.;
RT   "Isolation and characterisation of dimethylsulphoxide resistant
RT   variants from the human promyeloid cell line HL60.";
RL   Exp. Hematol. 11:828-833(1983).
//
RX   PubMed=6958930; DOI=10.1016/0145-2126(82)90006-6;
RA   Toksoz D., Bunce C.M., Stone P.C.W., Michell R.H., Brown G.;
RT   "Variant cell lines from the human promyelocyte line HL60.";
RL   Leuk. Res. 6:491-498(1982).
//