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Cellosaurus HL-60/LRARa403SN D.2 (CVCL_D1L6)

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Cell line name HL-60/LRARa403SN D.2
Accession CVCL_D1L6
Resource Identification Initiative To cite this cell line use: HL-60/LRARa403SN D.2 (RRID:CVCL_D1L6)
Comments Population: Caucasian.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:9864; RARA (Note=RARalpha403; truncated version AA 1-403).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute myeloid leukemia with maturation (NCIt: C7961)
Acute myeloblastic leukemia with maturation (ORDO: Orphanet_98834)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0002 (HL-60)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
Publications

PubMed=1334022; DOI=10.1101/gad.6.12a.2258
Schickwann Tsai, Stephen H. Bartelmez, Richard Heyman, Klaus Damm, Ronald Mark Evans, Steven J. Collins;
A mutated retinoic acid receptor-alpha exhibiting dominant-negative activity alters the lineage development of a multipotent hematopoietic cell line.
Genes Dev. 6:2258-2269(1992)

Cross-references
Encyclopedic resources Wikidata; Q127381769
Entry history
Entry creation30-Jan-2024
Last entry update14-Aug-2025
Version number4