ID   HL-60/LRARa403SN D.2
AC   CVCL_D1L6
DR   Wikidata; Q127381769
RX   PubMed=1334022;
CC   Population: Caucasian.
CC   Sequence variation: Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:9864; RARA (Note=RARalpha403; truncated version AA 1-403).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9154; Adult acute myeloid leukemia
DI   ORDO; Orphanet_519; Acute myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0002 ! HL-60
SX   Female
AG   36Y
CA   Cancer cell line
DT   Created: 30-01-24; Last updated: 19-12-24; Version: 3
//
RX   PubMed=1334022; DOI=10.1101/gad.6.12a.2258;
RA   Tsai S., Bartelmez S.H., Heyman R., Damm K., Evans R., Collins S.J.;
RT   "A mutated retinoic acid receptor-alpha exhibiting dominant-negative
RT   activity alters the lineage development of a multipotent
RT   hematopoietic cell line.";
RL   Genes Dev. 6:2258-2269(1992).
//