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Cellosaurus HL-60(DM) (CVCL_C8HP)

[Text version]
Cell line name HL-60(DM)
Synonyms HL-60 (DM)
Accession CVCL_C8HP
Resource Identification Initiative To cite this cell line use: HL-60(DM) (RRID:CVCL_C8HP)
Comments Population: Caucasian.
Karyotypic information: Contains a variable number (from 1 to 37) of double minute chromosomes (PubMed=3475162).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute myeloid leukemia with maturation (NCIt: C7961)
Acute myeloblastic leukemia with maturation (ORDO: Orphanet_98834)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0002 (HL-60)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
Publications

PubMed=3475162; DOI=10.1016/0165-4608(87)90362-1
Shin-ichi Misawa, Stephen P. Staal, Joseph R. Testa;
Amplification of the c-myc oncogene is associated with an abnormally banded region on chromosome 8 or double minute chromosomes in two HL-60 human leukemia sublines.
Cancer Genet. Cytogenet. 28:127-135(1987)

Cross-references
Encyclopedic resources Wikidata; Q123031676
Entry history
Entry creation05-Oct-2023
Last entry update14-Aug-2025
Version number4