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Cellosaurus Eos-HL-60 (CVCL_2892)

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Cell line name Eos-HL-60
Accession CVCL_2892
Resource Identification Initiative To cite this cell line use: Eos-HL-60 (RRID:CVCL_2892)
Comments Population: Caucasian.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute myeloid leukemia with maturation (NCIt: C7961)
Acute myeloblastic leukemia with maturation (ORDO: Orphanet_98834)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0002 (HL-60)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
STR profile Source(s): ECACC=96100920

Markers:
AmelogeninX
CSF1PO13,14
D5S81812
D7S82011,12
D13S3178,11
D16S53911
TH018
TPOX8,11
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

Cross-references
Cell line collections (Providers) ECACC; 96100920
Cell line databases/resources CLO; CLO_0002936
CLDB; cl5062
cancercelllines; CVCL_2892
LINCS_LDP; LCL-2055
Encyclopedic resources Wikidata; Q54832346
Gene expression databases GEO; GSM827454
Polymorphism and mutation databases Progenetix; CVCL_2892
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number30