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Cellosaurus HL-60/Vinc (CVCL_4967)

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Cell line name HL-60/Vinc
Synonyms HL60/Vinc
Accession CVCL_4967
Resource Identification Initiative To cite this cell line use: HL-60/Vinc (RRID:CVCL_4967)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_28445; Vincristine (VCR).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute myeloid leukemia with maturation (NCIt: C7961)
Acute myeloblastic leukemia with maturation (ORDO: Orphanet_98834)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0002 (HL-60)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
Publications

PubMed=2886122; DOI=10.1016/0006-291X(87)91560-9
Tim McGrath, Melvin S. Center;
Adriamycin resistance in HL60 cells in the absence of detectable P-glycoprotein.
Biochem. Biophys. Res. Commun. 145:1171-1176(1987)

PubMed=2573357; DOI=10.1016/0006-2952(89)90134-2
Tim McGrath, Chantal Latoud, Susan T. Arnold, Ahmad R. Safa, Ronald LaNay Felsted, Melvin S. Center;
Mechanisms of multidrug resistance in HL60 cells. Analysis of resistance associated membrane proteins and levels of mdr gene expression.
Biochem. Pharmacol. 38:3611-3619(1989)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4967
Anatomy/cell type resources BTO; BTO_0002591
Encyclopedic resources Wikidata; Q54889810
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number25