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Cellosaurus HL-60 248 (CVCL_UM46)

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Cell line name HL-60 248
Synonyms HL60 248; 248
Accession CVCL_UM46
Resource Identification Initiative To cite this cell line use: HL-60 248 (RRID:CVCL_UM46)
Comments Population: Caucasian.
Characteristics: The TP53 null parental cell line was transfected with a mutated TP53 sequence.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:11998; TP53 (Note=With p.Arg248Trp).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute myeloid leukemia with maturation (NCIt: C7961)
Acute myeloblastic leukemia with maturation (ORDO: Orphanet_98834)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0002 (HL-60)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
Publications

PubMed=8562479
Debabrata Banerjee, Heinz-Josef Lenz, Barbara Schnieders, David J. Manno, Jing-Fang Ju, C. Paul Spears, Daniel Hochhauser, Kathleen D. Danenberg, Peter V. Danenberg, Joseph Rocco Bertino;
Transfection of wild-type but not mutant p53 induces early monocytic differentiation in HL60 cells and increases their sensitivity to stress.
Cell Growth Differ. 6:1405-1413(1995)

PubMed=9607592
Jing-Fan Ju, Debabrata Banerjee, Heinz-Josef Lenz, Kathleen D. Danenberg, Thomas Donald Schmittgen, C. Paul Spears, Axel H. Schonthal, David J. Manno, Daniel Hochhauser, Joseph Rocco Bertino, Peter V. Danenberg;
Restoration of wild-type p53 activity in p53-null HL-60 cells confers multidrug sensitivity.
Clin. Cancer Res. 4:1315-1322(1998)

Cross-references
Cell line databases/resources cancercelllines; CVCL_UM46
Encyclopedic resources Wikidata; Q94211454
Entry history
Entry creation25-Feb-2019
Last entry update14-Aug-2025
Version number13