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Cellosaurus HL-60/DNR (CVCL_4458)

[Text version]
Cell line name HL-60/DNR
Synonyms HL60/DNR; HL60-DNR
Accession CVCL_4458
Resource Identification Initiative To cite this cell line use: HL-60/DNR (RRID:CVCL_4458)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:41977; Daunorubicin (Daunomycin).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; 11998; TP53; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0002 (HL-60)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
Publications

PubMed=9557624; DOI=10.1038/sj.leu.2400976
Mattii L., Barale R., Petrini M.
Use of the comet test in the evaluation of multidrug resistance of human cell lines.
Leukemia 12:627-632(1998)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4458
Anatomy/cell type resources BTO; BTO:0003573
Encyclopedic resources Wikidata; Q54889804
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number23