Cellosaurus cell line HyCyte HL-60 KO-hIRAK4 (CVCL

Cross-references
Cell line name	HyCyte HL-60 KO-hIRAK4
Synonyms	hIRAK4 knockout HL-60
Accession	CVCL_E1LB
Resource Identification Initiative	To cite this cell line use: HyCyte HL-60 KO-hIRAK4 (RRID:CVCL_E1LB)
Comments	Population: Caucasian. Doubling time: 48-72 hours (Hysigen=CGKO-M2295). Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:17967; IRAK4. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations	Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease	Adult acute myeloid leukemia with maturation (NCIt: C7961) Acute myeloblastic leukemia with maturation (ORDO: Orphanet_98834)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0002 (HL-60)
Sex of cell	Female
Age at sampling	36Y
Category	Cancer cell line
Cell line collections (Providers)	Hysigen; CGKO-M2295
Entry history
Entry creation	10-Sep-2024
Last entry update	14-Aug-2025
Version number	3