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Cellosaurus RED-3 (CVCL_8907)

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Cell line name RED-3
Accession CVCL_8907
Resource Identification Initiative To cite this cell line use: RED-3 (RRID:CVCL_8907)
Comments Problematic cell line: Contaminated. Shown to be a HL-60 derivative (PubMed=12592342; PubMed=20143388). Originally thought to originate from a 24 year old male patient suffering from acute lymphoblastic leukemia in second relapse.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00260.
Population: Caucasian.
Doubling time: 26 hours (CelloPub=CLPUB00690; CelloPub=CLPUB00691).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (PubMed=2659902).
Disease Adult acute myeloid leukemia with maturation (NCIt: C7961)
Acute myeloblastic leukemia with maturation (ORDO: Orphanet_98834)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0002 (HL-60)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

CLPUB00690
Robert Douglas Knight, Ernest C. Khan, Maryrita Kaiser Mallet, Daniel G. Wright;
Establishment of a new myeloid cell line from a patient with TdT(+) acute leukemia.
Blood 66 Suppl. 1:224a.783-224a.783(1985)

CLPUB00691
Maryrita Kaiser Mallet, Robert Douglas Knight, Ernest C. Khan, Daniel G. Wright;
Characterization of RED-3: a biphenotypic myeloid leukemia cell line.
Fed. Proc. 45:958.4678-958.4678(1986)

PubMed=2659902
Maryrita Kaiser Mallet, Shrikant M. Mane, Stephen Joseph Meltzer, Samuel W. Needleman;
c-myc amplification coexistent with activating N-ras point mutation in the biphenotypic leukemic cell line RED-3.
Leukemia 3:511-515(1989)

PubMed=12592342; DOI=10.1038/sj.leu.2402799
Hans Gunther Drexler, Wilhelm Gerhard Dirks, Yoshinobu Matsuo, Roderick A.F. MacLeod;
False leukemia-lymphoma cell lines: an update on over 500 cell lines.
Leukemia 17:416-426(2003)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8907
Biological sample resources BioSample; SAMN03151777
Encyclopedic resources Wikidata; Q54949691
Entry history
Entry creation06-Jun-2012
Last entry update14-Aug-2025
Version number31