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Cellosaurus HL-60/ara-C [USA 1984] (CVCL_Z938)

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Cell line name HL-60/ara-C [USA 1984]
Accession CVCL_Z938
Resource Identification Initiative To cite this cell line use: HL-60/ara-C [USA 1984] (RRID:CVCL_Z938)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_28680; Cytarabine (Arabinosylcytosine; Ara-C).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute myeloid leukemia with maturation (NCIt: C7961)
Acute myeloblastic leukemia with maturation (ORDO: Orphanet_98834)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0002 (HL-60)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
Publications

PubMed=6091869
Kapil N. Bhalla, Rabinandrath Nayak, Steven Grant;
Isolation and characterization of a deoxycytidine kinase-deficient human promyelocytic leukemic cell line highly resistant to 1-beta-D-arabinofuranosylcytosine.
Cancer Res. 44:5029-5037(1984)

Cross-references
Cell line databases/resources cancercelllines; CVCL_Z938
Encyclopedic resources Wikidata; Q54889803
Entry history
Entry creation10-Apr-2015
Last entry update14-Aug-2025
Version number20