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Cellosaurus HL60RG (CVCL_2945)

[Text version]
Cell line name HL60RG
Synonyms HL60-RG
Accession CVCL_2945
Resource Identification Initiative To cite this cell line use: HL60RG (RRID:CVCL_2945)
Comments Population: Caucasian.
Doubling time: ~20 hours (PubMed=22032829); ~2 days (Note=Lot 12182006) (JCRB=JCRB0006).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute myeloid leukemia with maturation (NCIt: C7961)
Acute myeloblastic leukemia with maturation (ORDO: Orphanet_98834)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0002 (HL-60)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
STR profile Source(s): JCRB=JCRB0006; PubMed=11416159

Markers:
AmelogeninX
CSF1PO13,14
D5S81812
D7S82011,12
D8S117912,13
D13S3178,11
D16S53911
D18S5114,15
D21S1130
FGA21,22,24
TH018
TPOX8,11
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Li-Qun Jia, Motonobu Osada, Chikashi Ishioka, Makio Gamo, Shuntaro Ikawa, Takao Suzuki, Hideki Shimodaira, Tomohito Niitani, Toshio Kudo, Mitoshi Akiyama, Narimiti Kimura ...Show all 18 authors... , Mitsuyoshi Matsuo, Hiroshi Mizusawa, Noriho Tanaka, Hideki Koyama, Masayoshi Namba, Ryunosuke Kanamaru, Toshio Kuroki; Show fewer authors
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
John R.W. Masters, Jim A. Thomson, Bernadette Daly-Burns, Yvonne A. Reid, Wilhelm Gerhard Dirks, Phil Packer, Lorraine H. Toji, Tadao Ohno, Hideyuki Tanabe, Colin Francis Arlett, Lloyd R. Kelland ...Show all 16 authors... , Maureen Harrison, Arvind K. Virmani, Timothy H. Ward, Karen L. Ayres, Paul G. Debenham; Show fewer authors
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

PubMed=22032829; DOI=10.1016/j.mrfmmm.2011.10.005
Yang Luan, Mieko Kogi, Palanisamy Rajaguru, Jin Ren, Teruhide Yamaguchi, Kazuhiro Suzuki, Takayoshi Suzuki;
Microarray analysis of responsible genes in increased growth rate in the subline of HL60 (HL60RG) cells.
Mutat. Res. 731:20-26(2012)

Cross-references
Cell line collections (Providers) JCRB; JCRB0006
Cell line databases/resources CLO; CLO_0037171
cancercelllines; CVCL_2945
LINCS_LDP; LCL-2056
Encyclopedic resources Wikidata; Q54889835
Gene expression databases GEO; GSM254145
Polymorphism and mutation databases Progenetix; CVCL_2945
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number32