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Cellosaurus HT-29 (CVCL_0320)

[Text version]
Cell line name HT-29
Synonyms HT 29; HT29
Accession CVCL_0320
Resource Identification Initiative To cite this cell line use: HT-29 (RRID:CVCL_0320)
Comments Part of: AstraZeneca Colorectal cell line (AZCL) panel.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: JFCR39 cancer cell line panel.
Part of: KuDOS 95 cell line panel.
Part of: MD Anderson Cell Lines Project.
Part of: NCI-60 cancer cell line panel.
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK 809.
Population: Caucasian.
Virology: Not susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=33389257).
Doubling time: 1.2 days (PubMed=6445228); 26.9 +- 3.3 hours (PubMed=3281752); 36.93 hours (PubMed=25944804); 24 hours (PubMed=25984343); 24 hours (PubMed=23546019); 21.87 +- 0.12 hours (PubMed=32927768); ~24 hours (CLS=300215); ~40-60 hours (DSMZ=ACC-299); 19.5 hours (NCI-DTP=HT-29); ~23 hours (PBCF).
Karyotypic information: Hypertriploid karyotype.
Microsatellite instability: Stable (MSS) (PubMed=9000147; PubMed=24042735; PubMed=24755471; PubMed=25926053; PubMed=28683746; Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Glycomics; N-glycan profiling.
Omics: Metabolomics.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Phenotyping; Fluorescent probe library screening.
Omics: Phenotyping; shRNA library screening.
Omics: Proteomics.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; PTM; Phosphorylation.
Omics: Proteomics; PTM; Phosphorylation; Quantitative.
Omics: Proteomics; Quantitative.
Omics: Proteomics; Subcellular; Extracellular vesicles.
Omics: Transcriptomics; lncRNA profiling; RT-qPCR platform.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; miRNA profiling; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; CNV analysis.
Omics: Variations; SNP array analysis.
Caution: Indicated in PubMed=11921276 as originating from an adenocarcinoma of the rectosigmoid part of the intestine, but is only indicated in the oldest publication (DOI=10.1007/978-1-4757-1647-4_5) as a colon adenocarcinoma.
Misspelling: HCT29; GEO=GSM206503.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
HLA typing Source: PubMed=77569
Class I
HLA-AA*01/11,03
HLA-BB*12,17

Source: PubMed=15748285
Class I
HLA-AA*01,24
HLA-BB*35,44:03:01
HLA-CC*04
Class II
HLA-DPDPB1*04:01
HLA-DQDQB1*02,03:02
HLA-DRDRB1*04:02,07:01

Source: PubMed=26589293
Class I
HLA-AA*01:01,24:03
HLA-BB*35:01,44:03
HLA-CC*04:01,04:01

Source: CLS=300215
Class I
HLA-AA*01:01:01,24:03:01
HLA-BB*35:01:01,44:03:01
HLA-CC*04:01:01
Class II
HLA-DPDPB1*04:01
HLA-DQDQA1*02:01:01,03:01:01
DQB1*02:02:01,03:02:01
HLA-DRDRB1*04:02:01,07:01:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.57
Native American1.05
East Asian, North3.24
East Asian, South0
South Asian4.8
European, North26.11
European, South63.24
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_9556 (2474/90)CVCL_9557 (2957/90)CVCL_9558 (3051/80)
CVCL_0144 (ARO)CVCL_2011 (CX-1)CVCL_DH88 (HT-29 BR100)
CVCL_DH89 (HT-29 BR200)CVCL_DH90 (HT-29 BR300)CVCL_H252 (HT-29 HD3)
CVCL_H253 (HT-29 HD4)CVCL_H254 (HT-29 HD6)CVCL_H255 (HT-29 HD8)
CVCL_C1KN (HT-29 Y1-16)CVCL_C1KP (HT-29 Y1-4)CVCL_C1KQ (HT-29 Y1-7)
CVCL_8118 (HT-29-D4)CVCL_4Z22 (HT-29-D9)CVCL_6833 (HT-29-G)
CVCL_J256 (HT-29-Luc [JCRB])CVCL_C8XV (HT-29-Luc [Ubigene])CVCL_5J34 (HT-29-luc-D6)
CVCL_G077 (HT-29-M6)CVCL_6834 (HT-29-MTX)CVCL_5J00 (HT-29-Red-FLuc)
CVCL_0I27 (HT-29/5-FU)CVCL_0T66 (HT-29/5-FU/S)CVCL_Y178 (HT-29/ADM)
CVCL_LJ30 (HT-29/B6)CVCL_C9ER (HT-29/Cas9-hyg)CVCL_Y177 (HT-29/cDDP)
CVCL_DE12 (HT-29/cl.f8)CVCL_H269 (HT-29/CPT)CVCL_Y179 (HT-29/ETP)
CVCL_WV61 (HT-29/SN-38)CVCL_E7J7 (HT-29(Cas9))CVCL_C3GK (HT-29_6244R)
CVCL_WN77 (HT-29KM)CVCL_EQ49 (HT-29R)CVCL_4V27 (HT-29R13)
CVCL_5U94 (HT29 LM1)CVCL_C764 (HT29-12B)CVCL_C765 (HT29-13G)
CVCL_C763 (HT29-16E)CVCL_5940 (HT29-18)CVCL_0323 (HT29-19A)
CVCL_E5Z7 (HT29-27)CVCL_E5Z8 (HT29-28)CVCL_E5Z9 (HT29-30)
CVCL_E5ZA (HT29-31)CVCL_A3CP (HT29-5FU resistant (1 microMolar))CVCL_A8P6 (HT29-5FU resistant (10 microMolar))
CVCL_A8P9 (HT29-5M12)CVCL_A8Q0 (HT29-5M21)CVCL_E9CB (HT29-Cx43)
CVCL_E7H8 (HT29-DR3)CVCL_5J20 (HT29-luc2)CVCL_A8BX (HT29-Lucia AhR)
CVCL_F0KM (HT29-MTX resistant (1 microMolar))CVCL_F0KN (HT29-MTX resistant (10 microMolar))CVCL_F0KP (HT29-MTX resistant (100 microMolar))
CVCL_5949 (HT29-OxR)CVCL_EQ23 (HT29-R)CVCL_E9CA (HT29-TK)
CVCL_2521 (HT29/219)CVCL_4V74 (HT29/L-OHP)CVCL_C8V7 (HTFU)
CVCL_8476 (HTOXAR3)CVCL_D6BR (HyCyte HT-29 KO-hCCAT2)CVCL_E1LC (HyCyte HT-29 KO-hDCAF4)
CVCL_E1LD (HyCyte HT-29 KO-hTIMM17B)CVCL_E3HK (HyCyte HT-29-Luc)CVCL_6301 (KAK-1)
CVCL_6302 (KAT-10)CVCL_6304 (KAT-4)CVCL_0370 (KAT-5)
CVCL_6305 (KAT-50)CVCL_6306 (KAT-7)CVCL_L095 (KM20)
CVCL_D889 (KM20L2)CVCL_YJ83 (LINTERNA HT-29)CVCL_6310 (MRO)
CVCL_7204 (MV-522)CVCL_M779 (RO-D81-1)CVCL_D9WF (Ubigene HT-29 ESRP2 KO)
CVCL_D9WG (Ubigene HT-29 ETHE1 KO)CVCL_D9WH (Ubigene HT-29 FKBP10 KO)CVCL_D9WI (Ubigene HT-29 HDGF KO)
CVCL_D9WJ (Ubigene HT-29 PIEZO1 KO)CVCL_D9WK (Ubigene HT-29 SELENBP1 KO)CVCL_D9WL (Ubigene HT-29 SIRT3 KO)
CVCL_D9WM (Ubigene HT-29 SQSTM1 KO)CVCL_2760 (WiDr)
Sex of cell Female
Age at sampling 44Y
Category Cancer cell line
STR profile Source(s): AddexBio=C0009004/48; ATCC=HTB-38; CCRID; CLS=300215; Cosmic-CLP=905939; DSMZ=ACC-299; ECACC=91072201; KCLB=30038; PubMed=11416159; PubMed=19372543; PubMed=25877200; PubMed=25926053; Technion Genomics Center

Markers:
AmelogeninX
CSF1PO11,12
D1S165615,16
D2S44111
D2S133819,23
D3S135815,17
D5S81811,12
D7S82010
D8S117910 (AddexBio=C0009004/48; CLS=300215; DSMZ=ACC-299; PubMed=19372543; PubMed=25877200)
10,16 (ATCC=HTB-38; CCRID; PubMed=11416159; Technion Genomics Center)
D10S124814,16
D12S39118.3,21
D13S31711 (AddexBio=C0009004/48; CLS=300215)
11,12 (ATCC=HTB-38; CCRID; Cosmic-CLP=905939; DSMZ=ACC-299; ECACC=91072201; KCLB=30038; PubMed=19372543; PubMed=25877200; PubMed=25926053; Technion Genomics Center)
D16S53911,12
D18S5113
D19S43314
D21S1129,30
D22S104516
FGA20,22
Penta D11,13
Penta E14,16
TH016,9
TPOX8,9
vWA17,19

Run an STR similarity search on this cell line
Web pages Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/htb-38-morphology-and-media
Info; MCLP; -; https://tcpaportal.org/mclp/
Info; NCI DTP; NCI-60; https://dtp.cancer.gov/discovery_development/nci-60/cell_list.htm
Info; Pawefish; -; https://www.cellosaurus.org/pawefish/ColonCellLineDescriptions/HT29.html
Info; StRAP; -; https://strap.nci.nih.gov/celline_detail.php?sample_id=15
Info; Synapse; PS-ON; https://www.synapse.org/#!Synapse:syn31544471
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-32.html
Info; Wikipedia; -; https://en.wikipedia.org/wiki/HT-29
Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/colon-cancer-xenograft/ht29-xenograft-model/
Provider; BRICS; BRICS0119; http://www.brics.ac.cn/cell/template/cell/cell_detail.html?id=3923
Provider; MSKCC; -; https://www.mskcc.org/research-advantage/support/technology/tangible-material/human-colorectal-adenocarcinoma-cell-line-ht-29
Publications

DOI=10.1007/978-1-4757-1647-4_5
Jorgen Fogh, Germain L. Trempe;
New human tumor cell lines.
(In book chapter) Human tumor cells in vitro; Fogh, Jorgen (eds.); pp.115-159; Springer; New York; USA (1975)

PubMed=1159834; DOI=10.1093/jnci/55.3.555
Sabine von Kleist, Edith Chany, Pascal Burtin, M. King, Jorgen Fogh;
Immunohistology of the antigenic pattern of a continuous cell line from a human colon tumor.
J. Natl. Cancer Inst. 55:555-560(1975)

PubMed=72600
Brahma Sharma;
In vitro immunization against human tumor cells with tumor cell fractions.
Cancer Res. 37:4660-4668(1977)

PubMed=327080; DOI=10.1093/jnci/59.1.221
Jorgen Fogh, Jens M. Fogh, Thomas Orfeo;
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Jorgen Fogh, William C. Wright, James D. Loveless;
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=864752; DOI=10.1093/jnci/58.6.1743
Christopher John Marshall, Leonard Maurice Franks, Anthony W. Carbonell;
Markers of neoplastic transformation in epithelial cell lines derived from human carcinomas.
J. Natl. Cancer Inst. 58:1743-1751(1977)

PubMed=77569; DOI=10.1111/j.1399-0039.1978.tb01259.x
Jons Ake Espmark, Lena Ahlqvist-Roth, Lena Sarne, Anita Persson;
Tissue typing of cells in culture. III. HLA antigens of established human cell lines. Attempts at typing by the mixed hemadsorption technique.
Tissue Antigens 11:279-286(1978)

PubMed=626984
Leonard C. Erickson, Rainhardt Osieka, Kurt W. Kohn;
Differential repair of 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1- nitrosourea-induced DNA damage in two human colon tumor cell lines.
Cancer Res. 38:802-808(1978)

PubMed=468301; PMCID=PMC1457289
Ludwik K. Trejdosiewicz, Avril J. Trejdosiewicz, Noel Russell Ling, Peter W. Dykes;
Growth enhancing property of human monocytes from normal donors and cancer patients.
Immunology 37:247-252(1979)

PubMed=6256643; DOI=10.1038/288724a0
Rufus S. Day 3rd, Chuck H.J. Ziolkowski, Dominic A. Scudiero, Sharon A. Meyer, Anthony S. Lubiniecki, Anthony Joseph Girardi, Sheila Margaret Galloway, Gaither D. Bynum;
Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains.
Nature 288:724-727(1980)

PubMed=6445228
Pamela M. Kimball, Michael G. Brattain;
Isolation of a cellular subpopulation from a human colonic carcinoma cell line.
Cancer Res. 40:1574-1579(1980)

PubMed=22282976; DOI=10.1093/carcin/1.1.21
Rufus S. Day 3rd, Chuck H.J. Ziolkowski, Dominic A. Scudiero, Sharon A. Meyer, Michael R. Mattern;
Human tumor cell strains defective in the repair of alkylation damage.
Carcinogenesis 1:21-32(1980)

PubMed=7017212; DOI=10.1093/jnci/66.6.1003
Marilyn S. Pollack, Socorro D. Heagney, Philip O. Livingston, Jorgen Fogh;
HLA-A, B, C and DR alloantigen expression on forty-six cultured human tumor cell lines.
J. Natl. Cancer Inst. 66:1003-1012(1981)

PubMed=7459858
Monique Rousset, Alain Zweibaum, Jorgen Fogh;
Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.
Cancer Res. 41:1165-1170(1981)

PubMed=6220172
Nicholas C. Dracopoli, Jorgen Fogh;
Polymorphic enzyme analysis of cultured human tumor cell lines.
J. Natl. Cancer Inst. 70:469-476(1983)

PubMed=6825208; DOI=10.1093/carcin/4.2.199
Daniel B. Yarosh, Robert S. Foote, Sankar Mitra, Rufus S. Day 3rd;
Repair of O6-methylguanine in DNA by demethylation is lacking in Mer- human tumor cell strains.
Carcinogenesis 4:199-205(1983)

PubMed=6500159; DOI=10.1159/000163283
Merrill Eric Gershwin, Daniel Lentz, Robert B. Owens;
Relationship between karyotype of tissue culture lines and tumorigenicity in nude mice.
Exp. Cell Biol. 52:361-370(1984)

PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720
Michael Jules Mattes, Carlos Cordon-Cardo, John L. Lewis Jr., Lloyd John Old, Kenneth Oliver Lloyd;
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=3518877; DOI=10.3109/07357908609038260
Jorgen Fogh;
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=3472642; DOI=10.1016/0165-4608(87)90267-6
Tchaw-Ren Chen, Douglas J. Drabkowski, Robert J. Hay, Marvin L. Macy, Ward Davis Peterson Jr.;
WiDr is a derivative of another colon adenocarcinoma cell line, HT-29.
Cancer Genet. Cytogenet. 27:125-134(1987)

PubMed=3281752
Christian L. Laboisse, Jean-Jose Maoret, Nicole Triadou, Chantal Augeron;
Restoration by polyethylene glycol of characteristics of intestinal differentiation in subpopulations of the human colonic adenocarcinoma cell line HT29.
Cancer Res. 48:2498-2504(1988)

PubMed=3335022
Michael C. Alley, Dominic A. Scudiero, Anne Monks, Miriam L. Hursey, Maciej J. Czerwinski, Donald L. Fine, Betty Jane Abbott, Joseph G. Mayo, Robert H. Shoemaker, Michael R. Boyd;
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.
Cancer Res. 48:589-601(1988)

PubMed=3349466
Isabelle Chantret, Alain Barbat, Elisabeth Dussaulx, Michael G. Brattain, Alain Zweibaum;
Epithelial polarity, villin expression, and enterocytic differentiation of cultured human colon carcinoma cells: a survey of twenty cell lines.
Cancer Res. 48:1936-1942(1988)

PubMed=2288877
Mohamed M. Hafez, Diogenes Infante, Sidney J. Winawer, Eileen Friedman;
Transforming growth factor beta 1 acts as an autocrine-negative growth regulator in colon enterocytic differentiation but not in goblet cell maturation.
Cell Growth Differ. 1:617-626(1990)

PubMed=1778766; DOI=10.1111/j.1349-7006.1991.tb01816.x; PMCID=PMC5918361
Eisuke Takeshima, Michinari Hamaguchi, Tadashi Watanabe, Seiji Akiyama, Masato Kataoka, Yukano Ohnishi, Heng-Yi Xiao, Yoshiyuki Nagai, Hiroshi Takagi;
Aberrant elevation of tyrosine-specific phosphorylation in human gastric cancer cells.
Jpn. J. Cancer Res. 82:1428-1435(1991)

PubMed=1937958; DOI=10.1002/ijc.2910490516
Thecla Lesuffleur, Anne Kornowski, Catherine Luccioni, Martine Muleris, Alain Barbat, Jacqueline Beaumatin, Elisabeth Dussaulx, Bernard Dutrillaux, Alain Zweibaum;
Adaptation to 5-fluorouracil of the heterogeneous human colon tumor cell line HT-29 results in the selection of cells committed to differentiation.
Int. J. Cancer 49:721-730(1991)

PubMed=2041050; DOI=10.1093/jnci/83.11.757
Anne Monks, Dominic A. Scudiero, Philip Skehan, Robert H. Shoemaker, Kenneth D. Paull, David T. Vistica, Curtis D. Hose, John Langley, Paul Cronise, Anne Vaigro-Wolff, Marcia Gray-Goodrich ...Show all 14 authors... , Hugh Campbell, Joseph G. Mayo, Michael R. Boyd; Show fewer authors
Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines.
J. Natl. Cancer Inst. 83:757-766(1991)

PubMed=1389533; DOI=10.1016/0959-8049(92)90031-V
Harald Lahm, Danuta Petral-Malec, Aysim Yilmaz-Ceyhan, Jurgen R. Fischer, Murielle Lorenzoni, Jean-Claude Givel, Nikolas Odartchenko;
Growth stimulation of a human colorectal carcinoma cell line by interleukin-1 and -6 and antagonistic effects of transforming growth factor beta 1.
Eur. J. Cancer 28A:1894-1899(1992)

PubMed=1730571; DOI=10.1007/BF02631079
Thomas J. Goodwin, John Milburn Jessup, David A. Wolf;
Morphologic differentiation of colon carcinoma cell lines HT-29 and HT-29KM in rotating-wall vessels.
In Vitro Cell. Dev. Biol. Anim. 28:47-60(1992)

PubMed=8464898; DOI=10.1073/pnas.90.7.2842; PMCID=PMC46192
Michael J. Browning, Peter Krausa, Andrew J. Rowan, David C. Bicknell, Julia Gwynaeth Bodmer, Walter Fred Bodmer;
Tissue typing the HLA-A locus from genomic DNA by sequence-specific PCR: comparison of HLA genotype and surface expression on colorectal tumor cell lines.
Proc. Natl. Acad. Sci. U.S.A. 90:2842-2845(1993)

PubMed=7972006; DOI=10.1073/pnas.91.23.11045; PMCID=PMC45163
Aikou Okamoto, Douglas J. Demetrick, Elisa A. Spillare, Koichi Hagiwara, S. Perwez Hussain, William P. Bennett, Kathleen Forrester, Brenda Isen Gerwin, Manuel Serrano, David H. Beach, Curtis Craig Harris;
Mutations and altered expression of p16INK4 in human cancer.
Proc. Natl. Acad. Sci. U.S.A. 91:11045-11049(1994)

PubMed=7651727
William Vasilios Kastrinakis, Nirasha Ramchurren, Karen M. Rieger, Donald T. Hess, Massimo Loda, Glenn Steele, Ian C. Summerhayes;
Increased incidence of p53 mutations is associated with hepatic metastasis in colorectal neoplastic progression.
Oncogene 11:647-652(1995)

PubMed=8895552; DOI=10.1002/(SICI)1097-0215(19960927)68:1<126::AID-IJC22>3.0.CO;2-8
Laurent Suardet, Chuan Li, John Bertram Little;
Radio-induced modulation of transforming growth factor beta1 sensitivity in a p53 wild-type human colorectal-cancer cell line.
Int. J. Cancer 68:126-131(1996)

PubMed=9000147
Paul-Henri Cottu, Francoise Muzeau, Anne Estreicher, Jean-Francois Flejou, Richard D. Iggo, Gilles Thomas, Richard Hamelin;
Inverse correlation between RER+ status and p53 mutation in colorectal cancer cell lines.
Oncogene 13:2727-2730(1996)

PubMed=9000572
Jean-Marc Hoang, Paul-Henri Cottu, Benedicte Thuille, Remi J. Salmon, Gilles Thomas, Richard Hamelin;
BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines.
Cancer Res. 57:300-303(1997)

PubMed=9294210; DOI=10.1073/pnas.94.19.10330; PMCID=PMC23362
Mohammad Ilyas, Ian Philip Mark Tomlinson, Andrew J. Rowan, Massimo Pignatelli, Walter Fred Bodmer;
Beta-catenin mutations in cell lines established from human colorectal cancers.
Proc. Natl. Acad. Sci. U.S.A. 94:10330-10334(1997)

PubMed=9331090
Patrick M. O'Connor, Joany Jackman, Insoo Bae, Timothy Gene Myers, Sai-Jun Fan, Masato Mutoh, Dominic A. Scudiero, Anne Monks, Edward A. Sausville, John N. Weinstein, Stephen H. Friend ...Show all 13 authors... , Albert J. Fornace Jr., Kurt W. Kohn; Show fewer authors
Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.
Cancer Res. 57:4285-4300(1997)

PubMed=10612807; DOI=10.1002/(SICI)1098-2264(200002)27:2<183::AID-GCC10>3.0.CO;2-P; PMCID=PMC4721570
B. Michael Ghadimi, Dan L. Sackett, Michael J. Difilippantonio, Evelin Schrock, Thomas Neumann, Annukka Jauho, Gert Auer, Thomas Ried;
Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations.
Genes Chromosomes Cancer 27:183-190(2000)

PubMed=10700174; DOI=10.1038/73432
Douglas T. Ross, Uwe Scherf, Michael Bruce Eisen, Charles M. Perou, Christian Rees, Paul T. Spellman, Vishwanath R. Iyer, Stefanie S. Jeffrey, Matt van de Rijn, Mark C. Waltham, Alexander Pergamenschikov ...Show all 18 authors... , Jeffrey C.F. Lee, Deval Lashkari, Dari Shalon, Timothy Gene Myers, John N. Weinstein, David Botstein, Patrick O'Reilly Brown; Show fewer authors
Systematic variation in gene expression patterns in human cancer cell lines.
Nat. Genet. 24:227-235(2000)

PubMed=10737795; DOI=10.1073/pnas.97.7.3352; PMCID=PMC16243
Andrew J. Rowan, Hanan Lamlum, Mohammad Ilyas, James M.D. Wheeler, Jannes Straub, Angeliki Papadopoulou, David C. Bicknell, Walter Fred Bodmer, Ian Philip Mark Tomlinson;
APC mutations in sporadic colorectal tumors: a mutational 'hotspot' and interdependence of the 'two hits'.
Proc. Natl. Acad. Sci. U.S.A. 97:3352-3357(2000)

PubMed=11226274; DOI=10.1073/pnas.041603298; PMCID=PMC30173
Wael M. Abdel-Rahman, Kanade Katsura, Willem Rens, Patricia A. Gorman, Denise Sheer, David C. Bicknell, Walter Fred Bodmer, Mark J. Arends, Andrew Hamilton Wyllie, Paul A.W. Edwards;
Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement.
Proc. Natl. Acad. Sci. U.S.A. 98:2538-2543(2001)

PubMed=11414198; DOI=10.1007/s004320000207
Harald Lahm, Sabine Andre, Andreas Hoeflich, Jurgen R. Fischer, Bernard Sordat, Herbert Kaltner, Eckhard Wolf, Hans-Joachim Gabius;
Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.
J. Cancer Res. Clin. Oncol. 127:375-386(2001)

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
John R.W. Masters, Jim A. Thomson, Bernadette Daly-Burns, Yvonne A. Reid, Wilhelm Gerhard Dirks, Phil Packer, Lorraine H. Toji, Tadao Ohno, Hideyuki Tanabe, Colin Francis Arlett, Lloyd R. Kelland ...Show all 16 authors... , Maureen Harrison, Arvind K. Virmani, Timothy H. Ward, Karen L. Ayres, Paul G. Debenham; Show fewer authors
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

PubMed=11526487; DOI=10.1038/sj.onc.1204611
Jacqueline Gayet, Xiao-Ping Zhou, Alex Duval, Sandra Rolland, Jean-Marc Hoang, Paul-Henri Cottu, Richard Hamelin;
Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines.
Oncogene 20:5025-5032(2001)

PubMed=11668190; DOI=10.1177/002215540104901105
Hilmar Quentmeier, Mary Osborn, Julia Reinhardt, Margarete Zaborski, Hans Gunther Drexler;
Immunocytochemical analysis of cell lines derived from solid tumors.
J. Histochem. Cytochem. 49:1369-1378(2001)

PubMed=11687795; DOI=10.1038/ng754
Antoine M. Snijders, Norma Jean Nowak, Richard Segraves, Stephanie Blackwood, Nils Brown, Jeffrey Conroy, Greg Hamilton, Anna Katherine Hindle, Bing Huey, Karen Kimura, Sindy Law ...Show all 19 authors... , Ken Myambo, Joel Palmer, Bauke Ylstra, Jingzhu Pearl Yue, Joe W. Gray, Ajay N. Jain, Daniel Pinkel, Donna G. Albertson; Show fewer authors
Assembly of microarrays for genome-wide measurement of DNA copy number.
Nat. Genet. 29:263-264(2001)

PubMed=11921276; DOI=10.1002/gcc.10003
Kanji Kawai, Carrie Viars, Karen C. Arden, David Tarin, Virginia Urquidi, Steve Goodison;
Comprehensive karyotyping of the HT-29 colon adenocarcinoma cell line.
Genes Chromosomes Cancer 34:1-8(2002)

PubMed=12068308; DOI=10.1038/nature00766
Helen R. Davies, Graham Robert Bignell, Charles Cox, Philip J. Stephens, Sarah Edkins, Sheila Clegg, Jon W. Teague, Hayley Woffendin, Mathew J. Garnett, William Bottomley, Neil Davis ...Show all 52 authors... , Ed Dicks, Rebecca Ewing, Yvonne Floyd, Kristian Gray, Sarah Hall, Rachel Hawes, Jaime Hughes, Vivian Kosmidou, Andrew Menzies, Catherine Mould, Adrian Parker, Claire Stevens, Stephen Watt, Steven Hooper, Rebecca Wilson, Hiran Jayatilake, Barry Austin Gusterson, Colin S. Cooper, Janet M. Shipley, Darren Hargrave, Kathy Pritchard-Jones, Norman J. Maitland, Georgia Chenevix-Trench, Gregory J. Riggins, Darell Doty Bigner, Giuseppe Palmieri, Antonio Cossu, Adrienne M. Flanagan, Andrew Nicholson, Judy W.C. Ho, Suet Yi Leung, Siu Tsan Yuen, Barbara L. Weber, Hilliard Foster Seigler, Timothy L. Darrow, Hugh F. Paterson, Richard Marais, Christopher John Marshall, Richard Wooster, Michael Rudolf Stratton, P. Andrew Futreal; Show fewer authors
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=15748285; DOI=10.1186/1479-5876-3-11; PMCID=PMC555742
Sharon Adams, Fu-Meei Robbins, Deborah Chen, Devika Wagage, Susan L. Holbeck, Herbert Carpenter Morse 3rd, David Stroncek, Francesco M. Marincola;
HLA class I and II genotype of the NCI-60 cell lines.
J. Transl. Med. 3:11.1-11.8(2005)

PubMed=15900046; DOI=10.1093/jnci/dji133
Tetsuo Mashima, Tomoko Oh-hara, Shigeo Sato, Mikiko Mochizuki, Yoshikazu Sugimoto, Kanami Yamazaki, Jun-ichi Hamada, Mitsuhiro Tada, Tetsuya Moriuchi, Yuichi Ishikawa, Yo Kato ...Show all 14 authors... , Hiroshi Tomoda, Takao Yamori, Takashi Tsuruo; Show fewer authors
p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target.
J. Natl. Cancer Inst. 97:765-777(2005)

PubMed=16083285; DOI=10.1021/pr050048h
Ji-Eun Kim, Steven R. Tannenbaum, Forest M. White;
Global phosphoproteome of HT-29 human colon adenocarcinoma cells.
J. Proteome Res. 4:1339-1346(2005)

PubMed=17088437; DOI=10.1158/1535-7163.MCT-06-0433; PMCID=PMC2705832
Ogechi N. Ikediobi, Helen R. Davies, Graham Robert Bignell, Sarah Edkins, Claire Stevens, Sarah O'Meara, Thomas Santarius, Tim Avis, Syd Barthorpe, Lisa Brackenbury, Gemma Buck ...Show all 49 authors... , Adam P. Butler, Jody Clements, Jennifer Cole, Ed Dicks, Simon Forbes, Kristian Gray, Kelly Halliday, Rachel Harrison, Katy Hills, Jonathan Hinton, Chris Hunter, Andy Jenkinson, David Jones, Vivian Kosmidou, Richard Lugg, Andrew Menzies, Tatiana Mironenko, Adrian Parker, Janet Perry, Keiran Martin Raine, David Richardson, Rebecca Shepherd, Alex Small, Raffaella Smith, Helen Solomon, Philip J. Stephens, Jon W. Teague, Calli Tofts, Jennifer Varian, Tony Webb, Sofie West, Sara Widaa, Andy Yates, William C. Reinhold, John N. Weinstein, Michael Rudolf Stratton, P. Andrew Futreal, Richard Wooster; Show fewer authors
Mutation analysis of 24 known cancer genes in the NCI-60 cell line set.
Mol. Cancer Ther. 5:2606-2612(2006)

PubMed=18258742; DOI=10.1073/pnas.0712176105; PMCID=PMC2268141
Muhammad Emaduddin, David C. Bicknell, Walter Fred Bodmer, Stephan M. Feller;
Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells.
Proc. Natl. Acad. Sci. U.S.A. 105:2358-2362(2008)

PubMed=19372543; DOI=10.1158/1535-7163.MCT-08-0921; PMCID=PMC4020356
Philip L. Lorenzi, William C. Reinhold, Sudhir Varma, Amy A. Hutchinson, Yves Pommier, Stephen Jacob Chanock, John N. Weinstein;
DNA fingerprinting of the NCI-60 cell line panel.
Mol. Cancer Ther. 8:713-724(2009)

PubMed=19927377; DOI=10.1002/gcc.20730; PMCID=PMC2818350
Turid Knutsen, Hesed Maria Padilla-Nash, Danny Wangsa, Linda Barenboim-Stapleton, Jordi Camps, Nicole E. McNeil, Michael J. Difilippantonio, Thomas Ried;
Definitive molecular cytogenetic characterization of 15 colorectal cancer cell lines.
Genes Chromosomes Cancer 49:204-223(2010)

PubMed=19941903; DOI=10.1016/j.jviromet.2009.11.022
Axel Karger, Barbara Bettin, Matthias Lenk, Thomas Christoph Mettenleiter;
Rapid characterisation of cell cultures by matrix-assisted laser desorption/ionisation mass spectrometric typing.
J. Virol. Methods 164:116-121(2010)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20570890; DOI=10.1158/0008-5472.CAN-10-0192; PMCID=PMC2943514
Manickam Janakiraman, Efsevia Vakiani, Zhao-Shi Zeng, Christine A. Pratilas, Barry Stephen Taylor, Dhananjay Chitale, Ensar Halilovic, Manda Wilson, Kety Huberman, Julio Cezar Marques Ricarte Filho, Yogindra Persaud ...Show all 21 authors... , Douglas A. Levine, James Alexander Fagin, Suresh C. Jhanwar, John M. Mariadason, Alex Lash, Marc Ladanyi, Leonard B. Saltz, Adriana Heguy, Philip B. Paty, David B. Solit; Show fewer authors
Genomic and biological characterization of exon 4 KRAS mutations in human cancer.
Cancer Res. 70:5901-5911(2010)

PubMed=20606684; DOI=10.1038/sj.bjc.6605780; PMCID=PMC2920028
Karin Bracht, Angela M. Nicholls, Ying Liu, Walter Fred Bodmer;
5-fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.
Br. J. Cancer 103:340-346(2010)

PubMed=20831567; DOI=10.1111/j.1582-4934.2010.01170.x; PMCID=PMC3918049
Yan-Lei Ma, Peng Zhang, Feng Wang, Mary Pat Moyer, Jian-Jun Yang, Zhi-Hua Liu, Jiang-Yun Peng, Hong-Qi Chen, Yu-Kun Zhou, Wei-Jie Liu, Huan-Long Qin;
Human embryonic stem cells and metastatic colorectal cancer cells shared the common endogenous human microRNA-26b.
J. Cell. Mol. Med. 15:1941-1954(2011)

PubMed=22068913; DOI=10.1073/pnas.1111840108; PMCID=PMC3219108
Jean-Pierre Gillet, Anna Maria Calcagno, Sudhir Varma, Miguel Marino, Lisa J. Green, Meena I. Vora, Chirayu Patel, Josiah N. Orina, Tatiana A. Eliseeva, Vineet Singal, Raji Padmanabhan ...Show all 17 authors... , Ben Davidson, Ram Ganapathi, Anil K. Sood, Bo R. Rueda, Suresh V. Ambudkar, Michael Marc Gottesman; Show fewer authors
Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance.
Proc. Natl. Acad. Sci. U.S.A. 108:18708-18713(2011)

PubMed=21912889; DOI=10.1007/s10637-011-9744-z
Hamish S. Sutherland, In Young Hwang, Elaine S. Marshall, Brent S. Lindsay, William Alexander Denny, Catherine Gilchrist, Wayne R. Joseph, Debra Greenhalgh, Emma Richardson, Philip Kestell, Angela Ding, Bruce Charles Baguley;
Therapeutic reactivation of mutant p53 protein by quinazoline derivatives.
Invest. New Drugs 30:2035-2045(2012)

PubMed=22336246; DOI=10.1016/j.bmc.2012.01.017
De-Xin Kong, Takao Yamori;
JFCR39, a panel of 39 human cancer cell lines, and its application in the discovery and development of anticancer drugs.
Bioorg. Med. Chem. 20:1947-1951(2012)

PubMed=22347499; DOI=10.1371/journal.pone.0031628; PMCID=PMC3276511
Xiao-Yang Ruan, Jean-Pierre A. Kocher, Yves Pommier, Hong-Fang Liu, William C. Reinhold;
Mass homozygotes accumulation in the NCI-60 cancer cell lines as compared to HapMap trios, and relation to fragile site location.
PLoS ONE 7:e31628.1-e31628.9(2012)

PubMed=22384151; DOI=10.1371/journal.pone.0032096; PMCID=PMC3285665
Jun-Seok Lee, Yun Kyung Kim, Han Jo Kim, Siti Hajar, Yee Ling Tan, Nam-Young Kang, Shin Hui Ng, Chang No Yoon, Young-Tae Chang;
Identification of cancer cell-line origins using fluorescence image-based phenomic screening.
PLoS ONE 7:e32096.1-e32096.8(2012)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22628656; DOI=10.1126/science.1218595; PMCID=PMC3526189
Mohit Jain, Roland Nilsson, Sonia Sharma, Nikhil Madhusudhan, Toshimori Kitami, Amanda L. Souza, Ran Kafri, Marc Wallace Kirschner, Clary B. Clish, Vamsi Krishna Mootha;
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation.
Science 336:1040-1044(2012)

PubMed=23272949; DOI=10.1186/1755-8794-5-66; PMCID=PMC3543849
Andreas Schlicker, Garry Beran, Christine M. Chresta, Gael McWalter, Alison Pritchard, Susie Weston, Sarah Runswick, Sara Davenport, Kerry Heathcote, Denis Alferez Castro, George Orphanides ...Show all 13 authors... , Tim French, Lodewyk F.A. Wessels; Show fewer authors
Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines.
BMC Med. Genomics 5:66.1-66.15(2012)

PubMed=22940288; DOI=10.1016/j.jsbmb.2012.08.003; PMCID=PMC3695570
Julia Hobaus, Irfete S. Fetahu, Maya Khorchide, Teresa Manhardt, Eniko Kallay;
Epigenetic regulation of the 1,25-dihydroxyvitamin D3 24-hydroxylase (CYP24A1) in colon cancer cells.
J. Steroid Biochem. Mol. Biol. 136:296-299(2013)

PubMed=23546019; DOI=10.3892/ijo.2013.1868
Amelie Petitprez, Virginie Poindessous, Djamila Ouaret, Marie Regairaz, Gerard Bastian, Eric Guerin, Alexandre E. Escargueil, Annette K. Larsen;
Acquired irinotecan resistance is accompanied by stable modifications of cell cycle dynamics independent of MSI status.
Int. J. Oncol. 42:1644-1653(2013)

PubMed=23631600; DOI=10.1021/pr400260h
Neil J. Loftus, Lindsay Lai, Robert W. Wilkinson, Rajesh Odedra, Ian D. Wilson, Alan J. Barnes;
Global metabolite profiling of human colorectal cancer xenografts in mice using HPLC-MS/MS.
J. Proteome Res. 12:2980-2986(2013)

PubMed=23856246; DOI=10.1158/0008-5472.CAN-12-3342; PMCID=PMC4893961
Ogan Demir Abaan, Eric C. Polley, Sean R. Davis, Yue-Lin J. Zhu, Sven Bilke, Robert L. Walker, Marbin A. Pineda, Yevgeniy Gindin, Yuan Jiang, William C. Reinhold, Susan L. Holbeck ...Show all 15 authors... , Richard M. Simon, James H. Doroshow, Yves Pommier, Paul S. Meltzer; Show fewer authors
The exomes of the NCI-60 panel: a genomic resource for cancer biology and systems pharmacology.
Cancer Res. 73:4372-4382(2013)

PubMed=23932154; DOI=10.1016/j.radonc.2013.06.032
Junius Salendo, Melanie Spitzner, Frank Kramer, Xin Zhang, Peter Jo, Hendrik A. Wolff, Julia Kitz, Silke Kaulfuss, Tim Beissbarth, Matthias Dobbelstein, Michael Ghadimi ...Show all 13 authors... , Marian Grade, Jochen Gaedcke; Show fewer authors
Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g.
Radiother. Oncol. 108:451-457(2013)

PubMed=23933261; DOI=10.1016/j.celrep.2013.07.018
Amin Moghaddas Gholami, Hannes Hahne, Zhi-Xiang Wu, Florian Johann Auer, Chen Meng, Mathias Wilhelm, Bernhard Kuster;
Global proteome analysis of the NCI-60 cell line panel.
Cell Rep. 4:609-620(2013)

PubMed=24042735; DOI=10.1038/oncsis.2013.35; PMCID=PMC3816225
Deeqa Ahmed, Peter W. Eide, Ina A. Eilertsen, Stine A. Danielsen, Mette Eknaes, Merete Hektoen, Guro Elisabeth Lind, Ragnhild Adelheid Lothe;
Epigenetic and genetic features of 24 colon cancer cell lines.
Oncogenesis 2:e71.1-e71.8(2013)

PubMed=24279929; DOI=10.1186/2049-3002-1-20; PMCID=PMC4178206
Sonia C. Dolfi, Leo Li-Ying Chan, Jean Qiu, Philip M. Tedeschi, Joseph Rocco Bertino, Kim Marie Hirshfield, Zoltan Nagy Oltvai, Alexei Vazquez;
The metabolic demands of cancer cells are coupled to their size and protein synthesis rates.
Cancer Metab. 1:20.1-20.13(2013)

PubMed=24670534; DOI=10.1371/journal.pone.0092047; PMCID=PMC3966786
Sudhir Varma, Yves Pommier, Margot Sunshine, John N. Weinstein, William C. Reinhold;
High resolution copy number variation data in the NCI-60 cancer cell lines from whole genome microarrays accessible through CellMiner.
PLoS ONE 9:e92047.1-e92047.15(2014)

PubMed=24755471; DOI=10.1158/0008-5472.CAN-14-0013
Dmitri Mouradov, Clare Sloggett, Robert N. Jorissen, Christopher G. Love, Shan Li, Antony Wilks Burgess, Diego Arango, Robert L. Strausberg, Daniel Buchanan, Samuel Wormald, Liam O'Connor ...Show all 17 authors... , Jennifer L. Wilding, David C. Bicknell, Ian Philip Mark Tomlinson, Walter Fred Bodmer, John M. Mariadason, Oliver M. Sieber; Show fewer authors
Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.
Cancer Res. 74:3238-3247(2014)

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Glenn S. Cowley, Barbara A. Weir, Francisca Vazquez, Pablo Tamayo, Justine A. Scott, Scott Rusin, Alexandra East-Seletsky, Levi D. Ali, William F.J. Gerath, Sarah E. Pantel, Patrick Hall Lizotte ...Show all 40 authors... , Guo-Zhi Jiang, Jessica Hsiao, Aviad Tsherniak, Elizabeth Dwinell, Simon Aoyama, Michael Okamoto, William Harrington, Ellen T. Gelfand, Thomas M. Green, Mark J. Tomko, Shuba Gopal, Terence C. Wong, Hu-Bo Li, Sara Howell, Nicolas Stransky, Ted Liefeld, Dongkeun Jang, Jonathan Bistline, Barbara Hill Meyers, Scott Allen Armstrong, Kenneth Carl Anderson, Kimberly Stegmaier, Michael Reich, David Pellman, Jesse S. Boehm, Jill P. Mesirov, Todd Robert Golub, David E. Root, William Chun Hahn; Show fewer authors
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035.1-140035.12(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25841592; DOI=10.1016/j.jprot.2015.03.019
Sander R. Piersma, Jaco C. Knol, Inge de Reus, Mariette Labots, Bharath K. Sampadi, Thang V. Pham, Yasushi Ishihama, Henk M.W. Verheul, Connie R. Jimenez;
Feasibility of label-free phosphoproteomics and application to base-line signaling of colorectal cancer cell lines.
J. Proteomics 127:247-258(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=25926053; DOI=10.1038/ncomms8002
Enzo Medico, Mariangela Russo, Gabriele Picco, Carlotta Cancelliere, Emanuele Valtorta, Giorgio Corti, Michela Buscarino, Claudio Isella, Simona Lamba, Barbara Martinoglio, Silvio Veronese ...Show all 19 authors... , Salvatore Siena, Andrea Sartore-Bianchi, Marco Beccuti, Marcella Mottolese, Michael Linnebacher, Francesca Cordero, Federica Di Nicolantonio, Alberto Bardelli; Show fewer authors
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

PubMed=25944804; DOI=10.1158/1078-0432.CCR-14-2457
Sarah Bazzocco, Higinio Dopeso, Fernando Carton-Garcia, Irati Macaya, Elena Andretta, Fiona Chionh, Paulo Rodrigues, Miriam Garrido, Hafid Alazzouzi, Rocio Nieto, Alex Sanchez ...Show all 15 authors... , Simo Schwartz Jr., Josipa Bilic, John M. Mariadason, Diego Arango; Show fewer authors
Highly expressed genes in rapidly proliferating tumor cells as new targets for colorectal cancer treatment.
Clin. Cancer Res. 21:3695-3704(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=29787047; DOI=10.1007/978-3-319-16104-4_11
Daniel Martinez-Maqueda, Beatriz Miralles, Isidra Recio;
HT29 cell line.
(In book chapter) The impact of food bioactives on health. In vitro and ex vivo models; Verhoeckx, Kitty & Cotter, Paul David & Lopez-Exposito, Ivan & Kleiveland, Charlotte Ramstad & Lea, Tor & Mackie, Alan Robert & Requena, Teresa & Swiatecka, Dominika & Wichers, Harry J. (eds.); pp.113-124; Springer; Cham; Switzerland (2015)

PubMed=26537799; DOI=10.1074/mcp.M115.051235; PMCID=PMC4762531
Stephanie Holst, Anna J.M. Deuss, Gabi W. van Pelt, Sandra Johanna van Vliet, Juan J. Garcia-Vallejo, Carolien A.M. Koeleman, Andre M. Deelder, Wilma E. Mesker, Rob A.E.M. Tollenaar, Yoann Rombouts, Manfred Wuhrer;
N-glycosylation profiling of colorectal cancer cell lines reveals association of fucosylation with differentiation and caudal type homebox 1 (CDX1)/villin mRNA expression.
Mol. Cell. Proteomics 15:124-140(2016)

PubMed=27377824; DOI=10.1038/sdata.2016.52; PMCID=PMC4932877
Pieter Mestdagh, Steve Lefever, Pieter-Jan Volders, Stefaan Derveaux, Jan Hellemans, Jo Vandesompele;
Long non-coding RNA expression profiling in the NCI60 cancer cell line panel using high-throughput RT-qPCR.
Sci. Data 3:160052.1-160052.6(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=27807467; DOI=10.1186/s13100-016-0078-4; PMCID=PMC5087121
John G. Zampella, Nemanja Rodic, Wan Rou Yang, Cheng Ran Lisa Huang, Jane Welch, Veena P. Gnanakkan, Toby Charles Cornish, Jef D. Boeke, Kathleen H. Burns;
A map of mobile DNA insertions in the NCI-60 human cancer cell panel.
Mob. DNA 7:20.1-20.11(2016)

PubMed=28179481; DOI=10.1158/1535-7163.MCT-16-0578
Noritaka Tanaka, Tetsuo Mashima, Anna Mizutani, Ayana Sato, Aki Aoyama, Bo Gong, Haruka Yoshida, Yukiko Muramatsu, Kento Nakata, Masaaki Matsuura, Ryohei Katayama ...Show all 15 authors... , Satoshi Nagayama, Naoya Fujita, Yoshikazu Sugimoto, Hiroyuki Seimiya; Show fewer authors
APC mutations as a potential biomarker for sensitivity to tankyrase inhibitors in colorectal cancer.
Mol. Cancer Ther. 16:752-762(2017)

PubMed=28192450; DOI=10.1371/journal.pone.0171435; PMCID=PMC5305277
Erik Fasterius, Cinzia Raso, Susan A. Kennedy, Nora Rauch, Par Lundin, Walter Kolch, Mathias Uhlen, Cristina Al-Khalili Szigyarto;
A novel RNA sequencing data analysis method for cell line authentication.
PLoS ONE 12:e0171435.1-e0171435.19(2017)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=28683746; DOI=10.1186/s12943-017-0691-y; PMCID=PMC5498998
Kaja Christine Graue Berg, Peter W. Eide, Ina A. Eilertsen, Bjarne Johannessen, Jarle Bruun, Stine A. Danielsen, Merete Bjornslett, Leonardo Andres Meza-Zepeda, Mette Eknaes, Guro Elisabeth Lind, Ola Myklebost ...Show all 14 authors... , Rolf Inge Skotheim, Anita Sveen, Ragnhild Adelheid Lothe; Show fewer authors
Multi-omics of 34 colorectal cancer cell lines -- a resource for biomedical studies.
Mol. Cancer 16:116.1-116.16(2017)

PubMed=28854368; DOI=10.1016/j.celrep.2017.08.010; PMCID=PMC5583477
Theodoros I. Roumeliotis, Steven P. Williams, Emanuel Goncalves, Clara Alsinet, Martin Del Castillo Velasco-Herrera, Nanne Aben, Fatemeh Zamanzad Ghavidel, Magali Michaut, Michael Schubert, Stacey Price, James C. Wright ...Show all 24 authors... , Lu Yu, Mi Yang, Rodrigo Dienstmann, Justin H. Guinney, Pedro Beltrao, Alvis Brazma, Mercedes Pardo, Oliver Stegle, David J. Adams, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Jyoti S. Choudhary; Show fewer authors
Genomic determinants of protein abundance variation in colorectal cancer cells.
Cell Rep. 20:2201-2214(2017)

PubMed=29101300; DOI=10.15252/msb.20177701; PMCID=PMC5731344
Martin Frejno, Riccardo Zenezini Chiozzi, Mathias Wilhelm, Heiner Koch, Run-Sheng Zheng, Susan Klaeger, Benjamin Ruprecht, Chen Meng, Karl Kramer, Anna Jarzab, Stephanie Heinzlmeir ...Show all 20 authors... , Elaine Johnstone, Enric Domingo, David James Kerr, Moritz Jesinghaus, Julia Slotta-Huspenina, Wilko Weichert, Stefan Knapp, Stephan M. Feller, Bernhard Kuster; Show fewer authors
Pharmacoproteomic characterisation of human colon and rectal cancer.
Mol. Syst. Biol. 13:951-951(2017)

PubMed=29207035; DOI=10.3892/ijo.2017.4206
Agata Olejniczak, Magdalena Szarynska, Zbigniew Kmiec;
In vitro characterization of spheres derived from colorectal cancer cell lines.
Int. J. Oncol. 52:599-612(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Fiona M. Behan, Francesco Iorio, Gabriele Picco, Emanuel Goncalves, Charlotte M. Beaver, Giorgia Migliardi, Rita Santos, Yanhua Rao, Francesco Sassi, Marika Pinnelli, Rizwan Ansari ...Show all 25 authors... , Sarah Harper, David Adam Jackson, Rebecca McRae, Rachel Pooley, Piers Wilkinson, Dieudonne J. van der Meer, David Dow, Carolyn A. Buser-Doepner, Andrea Bertotti, Livio Trusolino, Euan Alexander Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J. Garnett; Show fewer authors
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
David Paul Nusinow, John Szpyt, Mahmoud Ghandi, Christopher M. Rose, E. Robert McDonald 3rd, Marian Kalocsay, Judit Jane-Valbuena, Ellen T. Gelfand, Devin K. Schweppe, Mark P. Jedrychowski, Javad Golji ...Show all 20 authors... , Dale A. Porter, Tomas Rejtar, Y. Karen Wang, Gregory V. Kryukov, Frank Stegmeier, Brian K. Erickson, Levi Alexander Garraway, William Raj Sellers, Steven P. Gygi; Show fewer authors
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=32172478; DOI=10.1007/s12253-020-00805-3
Yu-Ting Xu, Lin Zhang, Qing-Ling Wang, Mao-Jin Zheng;
Comparison of different colorectal cancer with liver metastases models using six colorectal cancer cell lines.
Pathol. Oncol. Res. 26:2177-2183(2020)

PubMed=32927768; DOI=10.3390/cancers12092582; PMCID=PMC7564713
Jan Schulte am Esch, Beatrice Ariane Windmoller, Johannes Hanewinkel, Jonathan Storm, Christine Forster, Ludwig Wilkens, Marcus Kruger, Barbara Kaltschmidt, Christian Kaltschmidt;
Isolation and characterization of two novel colorectal cancer cell lines, containing a subpopulation with potential stem-like properties: treatment options by MYC/NMYC inhibition.
Cancers (Basel) 12:2582.1-2582.34(2020)

PubMed=33389257; DOI=10.1007/s10096-020-04106-0; PMCID=PMC7778494
Nathalie Wurtz, Gwilherm Penant, Priscilla Jardot, Nathalie Duclos, Bernard La Scola;
Culture of SARS-CoV-2 in a panel of laboratory cell lines, permissivity, and differences in growth profile.
Eur. J. Clin. Microbiol. Infect. Dis. 40:477-484(2021)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

PubMed=36648961; DOI=10.3390/proteomes11010003; PMCID=PMC9844407
Kathleen A. Heck, Havard T. Lindholm, Barbara Niederdorfer, Eirini Tsirvouli, Martin Kuiper, Asmund Flobak, Astrid Laegreid, Liv Thommesen;
Characterisation of colorectal cancer cell lines through proteomic profiling of their extracellular vesicles.
Proteomes 11:3.1-3.20(2023)

PubMed=38861359; DOI=10.1158/0008-5472.CAN-23-3031; PMCID=PMC11292194
Mark W. Kunkel, Nathan P. Coussens, Joel Morris, Ronald C. Taylor, Thomas S. Dexheimer, Eric M. Jones, James H. Doroshow, Beverly A. Teicher;
HTS384 NCI60: the next phase of the NCI60 screen.
Cancer Res. 84:2403-2416(2024)

Cross-references
Cell line collections (Providers) ABM; T8972
AddexBio; C0009004/48
ATCC; HTB-38
BCRJ; 0111
CancerTools; 161929
CCLV; CCLV-RIE 0960
CCTCC; GDC0149
CLS; 300215
DSMZ; ACC-299
ECACC; 91072201
IBRC; C10097
ICLC; HTL99026
IZSLER; BS TCL 132
KCB; KCB 200508YJ
KCLB; 30038
NCBI_Iran; C466
NCI-DTP; HT-29
Ubigene; YC-C008
Cell line databases/resources CLO; CLO_0004283
MCCL; MCC:0000213
CLDB; cl1747
CLDB; cl1748
CLDB; cl1749
CLDB; cl1751
CLDB; cl1752
CLDB; cl1753
CLDB; cl1754
CLDB; cl4978
CLDB; cl5205
cancercelllines; CVCL_0320
CCRID; 1101HUM-PUMC000109
CCRID; 3101HUMSCSP5032
CCRID; 3101HUMTCHu103
CCRID; 4201HUM-CCTCC00149
CCRID; 5301HUM-KCB05008YJ
Cell_Model_Passport; SIDM00136
ColonAtlas; HT29
Cosmic-CLP; 905939
DepMap; ACH-000552
DSMZCellDive; ACC-299
LINCS_LDP; LCL-1180
Lonza; 430
SKY/M-FISH/CGH; 1435
SKY/M-FISH/CGH; 2124
SKY/M-FISH/CGH; 2836
TOKU-E; 1968
Anatomy/cell type resources BTO; BTO_0000182
Biological sample resources BioSample; SAMN01821565
BioSample; SAMN03470953
BioSample; SAMN05292462
BioSample; SAMN10988348
ENCODE; ENCBS604AAA
ENCODE; ENCBS605AAA
ENCODE; ENCBS668UDT
ENCODE; ENCBS814TLB
ENCODE; ENCBS836FPI
ENCODE; ENCBS914HXH
CRISP screens repositories BioGRID_ORCS_Cell_line; 179
Chemistry resources ChEMBL-Cells; CHEMBL3307768
ChEMBL-Targets; CHEMBL384
GDSC; 905939
PharmacoDB; HT29_630_2019
PubChem_Cell_line; CVCL_0320
Encyclopedic resources Wikidata; Q28334700
Experimental variables resources EFO; EFO_0001193
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM811
GEO; GSM2112
GEO; GSM50190
GEO; GSM50254
GEO; GSM206503
GEO; GSM274780
GEO; GSM288491
GEO; GSM288497
GEO; GSM288499
GEO; GSM513815
GEO; GSM514295
GEO; GSM736967
GEO; GSM741261
GEO; GSM743445
GEO; GSM799333
GEO; GSM799396
GEO; GSM827150
GEO; GSM887141
GEO; GSM888212
GEO; GSM1006213
GEO; GSM1006214
GEO; GSM1006215
GEO; GSM1153403
GEO; GSM1178239
GEO; GSM1178240
GEO; GSM1178241
GEO; GSM1181252
GEO; GSM1181366
GEO; GSM1346844
GEO; GSM1374561
GEO; GSM1374562
GEO; GSM1374563
GEO; GSM1374564
GEO; GSM1448179
GEO; GSM1669913
GEO; GSM2124658
GEO; GSM2550003
Medical resources MeSH; D019073
Metabolomic databases MetaboLights; MTBLS227
MetaboLights; MTBLS1358
Polymorphism and mutation databases Cosmic; 685867
Cosmic; 711273
Cosmic; 720331
Cosmic; 738929
Cosmic; 755308
Cosmic; 875295
Cosmic; 875898
Cosmic; 876716
Cosmic; 887217
Cosmic; 889523
Cosmic; 897459
Cosmic; 902789
Cosmic; 905939
Cosmic; 913891
Cosmic; 934562
Cosmic; 948132
Cosmic; 974246
Cosmic; 983739
Cosmic; 995412
Cosmic; 1043817
Cosmic; 1045405
Cosmic; 1057765
Cosmic; 1067225
Cosmic; 1071887
Cosmic; 1092605
Cosmic; 1122326
Cosmic; 1132575
Cosmic; 1154652
Cosmic; 1175842
Cosmic; 1176613
Cosmic; 1184093
Cosmic; 1184326
Cosmic; 1223142
Cosmic; 1248331
Cosmic; 1295658
Cosmic; 1299294
Cosmic; 1305355
Cosmic; 1310947
Cosmic; 1312339
Cosmic; 1436019
Cosmic; 1466816
Cosmic; 1479609
Cosmic; 1481417
Cosmic; 1482521
Cosmic; 1524327
Cosmic; 1537489
Cosmic; 1571769
Cosmic; 1609503
Cosmic; 1676733
Cosmic; 1708406
Cosmic; 1803945
Cosmic; 1888955
Cosmic; 1889160
Cosmic; 1933016
Cosmic; 1945866
Cosmic; 1995448
Cosmic; 1998447
Cosmic; 2036654
Cosmic; 2052596
Cosmic; 2145575
Cosmic; 2156939
Cosmic; 2301545
Cosmic; 2301988
Cosmic; 2389572
Cosmic; 2433757
Cosmic; 2550354
Cosmic; 2646771
Cosmic; 2664047
Cosmic; 2667882
Cosmic; 2668251
Cosmic; 2727481
Cosmic; 2760077
Cosmic; 2787549
Cosmic; 2800591
Cosmic; 2811052
IARC_TP53; 23
LiGeA; CCLE_686
Progenetix; CVCL_0320
Proteomic databases PRIDE; PRD000369
PRIDE; PRD000414
PRIDE; PXD001271
PRIDE; PXD001550
PRIDE; PXD003623
PRIDE; PXD005235
PRIDE; PXD005354
PRIDE; PXD005355
PRIDE; PXD005942
PRIDE; PXD005946
PRIDE; PXD030304
PRIDE; PXD037651
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
EGA; EGAS00001002554
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number51