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Cellosaurus HT29-16E (CVCL_C763)

[Text version]
Cell line name HT29-16E
Synonyms HT29 16E; HT-29 16E; HT29-Cl.16E; HT29-cl16E; HT29 clone 16E; Cl.16E
Accession CVCL_C763
Resource Identification Initiative To cite this cell line use: HT29-16E (RRID:CVCL_C763)
Comments Population: Caucasian.
Doubling time: 43.37 hours (PubMed=25944804).
Misspelling: C1.16E; Note=Occasionally.
Misspelling: HT29-C1.16E; ABM=T8213; Note=In old versions, corrected in Jan 2025.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0320 (HT-29)
Sex of cell Female
Age at sampling 44Y
Category Cancer cell line
Publications

PubMed=6744312
Chantal Augeron, Christian L. Laboisse;
Emergence of permanently differentiated cell clones in a human colonic cancer cell line in culture after treatment with sodium butyrate.
Cancer Res. 44:3961-3969(1984)

PubMed=8801204; DOI=10.1136/gut.38.2.240; PMCID=PMC1383030
Anne Jarry, Genevieve Vallette, Jean-Eric Branka, Christian L. Laboisse;
Direct secretory effect of interleukin-1 via type I receptors in human colonic mucous epithelial cells (HT29-Cl.16E).
Gut 38:240-242(1996)

PubMed=25944804; DOI=10.1158/1078-0432.CCR-14-2457
Sarah Bazzocco, Higinio Dopeso, Fernando Carton-Garcia, Irati Macaya, Elena Andretta, Fiona Chionh, Paulo Rodrigues, Miriam Garrido, Hafid Alazzouzi, Rocio Nieto, Alex Sanchez ...Show all 15 authors... , Simo Schwartz Jr., Josipa Bilic, John M. Mariadason, Diego Arango; Show fewer authors
Highly expressed genes in rapidly proliferating tumor cells as new targets for colorectal cancer treatment.
Clin. Cancer Res. 21:3695-3704(2015)

Cross-references
Cell line collections (Providers) ABM; T8213
Cell line databases/resources cancercelllines; CVCL_C763
Encyclopedic resources Wikidata; Q54896586
Entry history
Entry creation22-Oct-2012
Last entry update10-Apr-2025
Version number24