ID   HT29-16E
AC   CVCL_C763
SY   HT29 16E; HT-29 16E; HT29-Cl.16E; HT29-cl16E; HT29 clone 16E; Cl.16E
DR   cancercelllines; CVCL_C763
DR   Wikidata; Q54896586
RX   PubMed=6744312;
RX   PubMed=8801204;
RX   PubMed=25944804;
CC   Population: Caucasian.
CC   Doubling time: 43.37 hours (PubMed=25944804).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
CC   Misspelling: C1.16E; Note=Occasionally.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0320 ! HT-29
SX   Female
AG   44Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 05-10-23; Version: 22
//
RX   PubMed=6744312;
RA   Augeron C., Laboisse C.L.;
RT   "Emergence of permanently differentiated cell clones in a human
RT   colonic cancer cell line in culture after treatment with sodium
RT   butyrate.";
RL   Cancer Res. 44:3961-3969(1984).
//
RX   PubMed=8801204; DOI=10.1136/gut.38.2.240;
RA   Jarry A., Vallette G., Branka J.-E., Laboisse C.L.;
RT   "Direct secretory effect of interleukin-1 via type I receptors in
RT   human colonic mucous epithelial cells (HT29-Cl.16E).";
RL   Gut 38:240-242(1996).
//
RX   PubMed=25944804; DOI=10.1158/1078-0432.CCR-14-2457;
RA   Bazzocco S., Dopeso H., Carton-Garcia F., Macaya I., Andretta E.,
RA   Chionh F., Rodrigues P., Garrido M., Alazzouzi H., Nieto R.,
RA   Sanchez A., Schwartz S. Jr., Bilic J., Mariadason J.M., Arango D.;
RT   "Highly expressed genes in rapidly proliferating tumor cells as new
RT   targets for colorectal cancer treatment.";
RL   Clin. Cancer Res. 21:3695-3704(2015).
//