| Cell line name |
HT29-R |
| Synonyms |
HT29R |
| Accession |
CVCL_EQ23 |
| Resource Identification Initiative |
To cite this cell line use: HT29-R (RRID:CVCL_EQ23) |
| Comments |
Population: Caucasian. Selected for resistance to: ChEBI; CHEBI_44185; Methotrexate (MTX). Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
| Sequence variations |
- Mutation; HGNC; HGNC:583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
|
| Disease |
Colon adenocarcinoma (NCIt: C4349) |
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
| Hierarchy |
Parent: CVCL_0320 (HT-29) |
| Sex of cell |
Female |
| Age at sampling |
44Y |
| Category |
Cancer cell line |
| Publications | PubMed=17945194; DOI=10.1016/j.bcp.2007.08.034 Elisabet Selga, Veronique Noe, Carlos J. Ciudad; Transcriptional regulation of aldo-keto reductase 1C1 in HT29 human colon cancer cells resistant to methotrexate: role in the cell cycle and apoptosis. Biochem. Pharmacol. 75:414-426(2008) PubMed=18694510; DOI=10.1186/1755-8794-1-35; PMCID=PMC2527490 Elisabet Selga, Cristina Morales, Veronique Noe, Miguel Angel Peinado, Carlos J. Ciudad; Role of caveolin 1, E-cadherin, enolase 2 and PKCalpha on resistance to methotrexate in human HT29 colon cancer cells. BMC Med. Genomics 1:35.1-35.17(2008) |
| Cross-references |
| Cell line databases/resources |
cancercelllines; CVCL_EQ23
ColonAtlas; HT29R
|
| Encyclopedic resources |
Wikidata; Q54896594
|
| Gene expression databases |
GEO; GSM288501
GEO; GSM288502
GEO; GSM288536
|
| Entry history |
| Entry creation | 26-Sep-2016 |
| Last entry update | 19-Dec-2024 |
| Version number | 20 |
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