ID   HT29-R
AC   CVCL_EQ23
SY   HT29R
DR   cancercelllines; CVCL_EQ23
DR   ColonAtlas; HT29R
DR   GEO; GSM288501
DR   GEO; GSM288502
DR   GEO; GSM288536
DR   Wikidata; Q54896594
RX   PubMed=17945194;
RX   PubMed=18694510;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:44185; Methotrexate (MTX).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0320 ! HT-29
SX   Female
AG   44Y
CA   Cancer cell line
DT   Created: 26-09-16; Last updated: 05-10-23; Version: 19
//
RX   PubMed=17945194; DOI=10.1016/j.bcp.2007.08.034;
RA   Selga E., Noe V., Ciudad C.J.;
RT   "Transcriptional regulation of aldo-keto reductase 1C1 in HT29 human
RT   colon cancer cells resistant to methotrexate: role in the cell cycle
RT   and apoptosis.";
RL   Biochem. Pharmacol. 75:414-426(2008).
//
RX   PubMed=18694510; DOI=10.1186/1755-8794-1-35;
RA   Selga E., Morales C., Noe V., Peinado M.A., Ciudad C.J.;
RT   "Role of caveolin 1, E-cadherin, enolase 2 and PKCalpha on resistance
RT   to methotrexate in human HT29 colon cancer cells.";
RL   BMC Med. Genomics 1:35.1-35.17(2008).
//