| Cell line name |
RO-D81-1 |
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| Accession |
CVCL_M779 |
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| Resource Identification Initiative |
To cite this cell line use: RO-D81-1 (RRID:CVCL_M779) |
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| Comments |
Problematic cell line: Contaminated. Shown to be a HT-29 derivative (PubMed=23472229). Originally thought to originate from a thyroid gland medullary carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00482. |
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| Sequence variations |
- Mutation; HGNC; 583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Colon adenocarcinoma (NCIt: C4349) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0320 (HT-29) |
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| Sex of cell |
Female |
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| Age at sampling |
44Y |
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| Category |
Cancer cell line |
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| Web pages |
https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx |
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| Publications | PubMed=2538133; DOI=10.1001/archotol.1989.01860280076020
Abemayor E., Sidell N., Juillard G.J.-F.
Human medullary thyroid carcinoma. Initial characterization and in vitro differentiation of two new cell lines.
Arch. Otolaryngol. Head Neck Surg. 115:478-483(1989) PubMed=23472229; DOI=10.1210/jc.2012-4181
Dadon T., Ball D., Nelkin B.D.
Misidentification of putative medullary thyroid cancer cell lines RO-H85-1 and RO-D81-1.
J. Clin. Endocrinol. Metab. 98:954-955(2013) |
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| Cross-references |
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| Biological sample resources |
BioSample; SAMN03151796
|
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| Encyclopedic resources |
Wikidata; Q54950797
|
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| Entry history |
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| Entry creation | 05-Nov-2013 |
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| Last entry update | 21-Mar-2023 |
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| Version number | 21 |
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