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Cellosaurus RO-D81-1 (CVCL_M779)

[Text version]
Cell line name RO-D81-1
Accession CVCL_M779
Resource Identification Initiative To cite this cell line use: RO-D81-1 (RRID:CVCL_M779)
Comments Problematic cell line: Contaminated. Shown to be a HT-29 derivative (PubMed=23472229). Originally thought to originate from a thyroid gland medullary carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00482.
Population: Caucasian.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0320 (HT-29)
Sex of cell Female
Age at sampling 44Y
Category Cancer cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx

PubMed=2538133; DOI=10.1001/archotol.1989.01860280076020
Abemayor E., Sidell N., Juillard G.J.-F.
Human medullary thyroid carcinoma. Initial characterization and in vitro differentiation of two new cell lines.
Arch. Otolaryngol. Head Neck Surg. 115:478-483(1989)

PubMed=23472229; DOI=10.1210/jc.2012-4181
Dadon T., Ball D., Nelkin B.D.
Misidentification of putative medullary thyroid cancer cell lines RO-H85-1 and RO-D81-1.
J. Clin. Endocrinol. Metab. 98:954-955(2013)

Cell line databases/resources cancercelllines; CVCL_M779
Biological sample resources BioSample; SAMN03151796
Encyclopedic resources Wikidata; Q54950797
Entry history
Entry creation05-Nov-2013
Last entry update02-May-2024
Version number24