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Cellosaurus HT29-DR3 (CVCL_E7H8)

[Text version]
Cell line name HT29-DR3
Accession CVCL_E7H8
Resource Identification Initiative To cite this cell line use: HT29-DR3 (RRID:CVCL_E7H8)
Comments Population: Caucasian.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11910; TNFRSF25 (Note=With a C-terminal 3xFLAG tag).
Genetic integration: Method=Transduction; Gene=UniProtKB; P33967; B.cereus Bsr.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0320 (HT-29)
Sex of cell Female
Age at sampling 44Y
Category Cancer cell line
Publications

PubMed=30688306; DOI=10.3791/58705
Wang X., Zhou J.-M., Qi C., Wang G.-L.
Establishing cell lines overexpressing DR3 to assess the apoptotic response to anti-mitotic therapeutics.
J. Vis. Exp. 143:e58705.1-e58705.6(2019)

Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1