Cell line name |
HT29-DR3 |
Accession |
CVCL_E7H8 |
Resource Identification Initiative |
To cite this cell line use: HT29-DR3 (RRID:CVCL_E7H8) |
Comments |
Population: Caucasian. Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11910; TNFRSF25 (Note=With a C-terminal 3xFLAG tag). Genetic integration: Method=Transduction; Gene=UniProtKB; P33967; B.cereus Bsr. Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
Sequence variations |
- Mutation; HGNC; HGNC:583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
|
Disease |
Colon adenocarcinoma (NCIt: C4349) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0320 (HT-29) |
Sex of cell |
Female |
Age at sampling |
44Y |
Category |
Cancer cell line |
Publications | PubMed=30688306; DOI=10.3791/58705 Wang X., Zhou J.-M., Qi C., Wang G.-L. Establishing cell lines overexpressing DR3 to assess the apoptotic response to anti-mitotic therapeutics. J. Vis. Exp. 143:e58705.1-e58705.6(2019) |
Entry history |
Entry creation | 10-Apr-2025 |
Last entry update | 10-Apr-2025 |
Version number | 1 |
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